Generation of thalamic neurons from mouse embryonic stem cells

The thalamus is a diencephalic structure that plays crucial roles in relaying and modulating sensory and motor information to the neocortex. The thalamus develops in the dorsal part of the neural tube at the level of the caudal forebrain. However, the molecular mechanisms that are essential for thal...

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Veröffentlicht in:	Development (Cambridge) 2017-04, Vol.144 (7), p.1211-1220
Hauptverfasser:	Shiraishi, Atsushi, Muguruma, Keiko, Sasai, Yoshiki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons Bone Morphogenetic Protein 7 - pharmacology Cell Aggregation - drug effects Cell culture Cells, Cultured Embryo cells Embryoid Bodies - cytology Embryoid Bodies - drug effects Embryos Enzyme inhibitors Extracellular signal-regulated kinase Forebrain Gene expression Glutamic acid transporter Insulin MAP kinase MAP Kinase Signaling System - drug effects Mice Mice, Inbred ICR Mitogen-Activated Protein Kinase Kinases - metabolism Molecular modelling Mouse Embryonic Stem Cells - cytology Mouse Embryonic Stem Cells - drug effects Mouse Embryonic Stem Cells - metabolism Neocortex Neural stem cells Neural tube Neurites - drug effects Neurites - metabolism Neurogenesis Neurons - cytology Neurons - drug effects Neurons - metabolism Neuropeptides - metabolism Organ Culture Techniques Otx2 protein Pax6 protein Protein Kinase Inhibitors - pharmacology Rats, Sprague-Dawley Stem cell transplantation Stem cells Thalamus Thalamus - cytology Transcription Factor 7-Like 2 Protein - metabolism Transplantation
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