EFFECT OF HYPOCALCAEMIA ON GLUCOSE METABOLISM IN HYPERKETONAEMIC PIGLETS
In nine 2- to 3-month-old hyperketonaemic piglets the kinetics of glucose and D-[beta]-hydroxybutyrate (D-BHB) metabolism were studied during hypo- and normocalcaemia in paired experiments. Hyperketonaemia (1á3 and 2á5 mmol D-BHB (l plasma)-1) was generated by a stepwise increase of DL-BHB infusion....
Gespeichert in:
| Veröffentlicht in: | Experimental physiology 1999-07, Vol.84 (4), p.707-723 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 723 |
|---|---|
| container_issue | 4 |
| container_start_page | 707 |
| container_title | Experimental physiology |
| container_volume | 84 |
| creator | SCHLUMBOHM, C. HARMEYER, J. |
| description | In nine 2- to 3-month-old hyperketonaemic piglets the kinetics of glucose and D-[beta]-hydroxybutyrate (D-BHB) metabolism were studied during hypo- and normocalcaemia in paired experiments. Hyperketonaemia (1á3 and 2á5 mmol D-BHB (l plasma)-1) was generated by a stepwise increase of DL-BHB infusion. Hypocalcaemia spontaneously developed in five piglets due to an inherited calcitriol deficiency and was induced in four control piglets by a continuous infusion of Na2-EDTA. The method of single isotopic marker injections of glucose and D-BHB was used to calculate replacement rates, rate constants and half-lives of glucose and D-BHB in plasma. When DL-BHB was infused at the same rate into normo- and hypocalcaemic piglets, hypocalcaemia reduced the rate constant of glucose by 20-30 % and the replacement rate of glucose by 34 %. In the presence of hyperketonaemia, hypocalcaemia increased the rate of replacement of D-BHB by 6-40 %. The replacement rate represents the sum of endogenous production and the rate of DL-BHB infusion. This observation shows that the endogenous production of D-BHB was higher during hypocalcaemia than during normocalcaemia. |
| doi_str_mv | 10.1111/j.1469-445X.1999.01841.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1891850249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1111_j_1469_445X_1999_01841_x</cupid><sourcerecordid>1891850249</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4621-a7174cf68a5b23eebc84d0ca71a3494663e132934c6a0c9fc0d69488be60cad23</originalsourceid><addsrcrecordid>eNqNkEFv2jAYhq1qU0u7_oUpp2mXZHZiHHvSDjRyIGogqKTSdvqUOKYEQUNjEOXfz2nQ1Fvniy37eV_rexByCPaIXT_WHqFMuJQOf3tECOFhwinxXi_Q4N_DJzTAYshdzEJ8ha6NWWNMAszpJboimHLi-3yAJjKOZZQ7WexM_syzaJRGIzlNRk42c8bpY5QtpDOV-eguS5PF1ElmHSYf7mWezTowcubJOJX54gv6vCw2Rt-e9xv0GMs8mrhpNk5sraso84lbhCSkasl4MSz9QOtScVphZa-LgArKWKBJ4IuAKlZgJZYKV0xQzkvNLFX5wQ363vfu2ubloM0etrVRerMpnnVzMEC4IHyIfSosyntUtY0xrV7Crq23RXsCgqHzCGvodEGnCzqP8OYRXm306_mXQ7nV1btgL84Cv3rgWG_06b-LQc4n3cnmv_X5Vf20Otatht3qZOrGNKrW-xNwChRCHFrw53mIYlu2dfWkYd0c2mfr-OMx_gLGF5n4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1891850249</pqid></control><display><type>article</type><title>EFFECT OF HYPOCALCAEMIA ON GLUCOSE METABOLISM IN HYPERKETONAEMIC PIGLETS</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>SCHLUMBOHM, C. ; HARMEYER, J.</creator><creatorcontrib>SCHLUMBOHM, C. ; HARMEYER, J.</creatorcontrib><description>In nine 2- to 3-month-old hyperketonaemic piglets the kinetics of glucose and D-[beta]-hydroxybutyrate (D-BHB) metabolism were studied during hypo- and normocalcaemia in paired experiments. Hyperketonaemia (1á3 and 2á5 mmol D-BHB (l plasma)-1) was generated by a stepwise increase of DL-BHB infusion. Hypocalcaemia spontaneously developed in five piglets due to an inherited calcitriol deficiency and was induced in four control piglets by a continuous infusion of Na2-EDTA. The method of single isotopic marker injections of glucose and D-BHB was used to calculate replacement rates, rate constants and half-lives of glucose and D-BHB in plasma. When DL-BHB was infused at the same rate into normo- and hypocalcaemic piglets, hypocalcaemia reduced the rate constant of glucose by 20-30 % and the replacement rate of glucose by 34 %. In the presence of hyperketonaemia, hypocalcaemia increased the rate of replacement of D-BHB by 6-40 %. The replacement rate represents the sum of endogenous production and the rate of DL-BHB infusion. This observation shows that the endogenous production of D-BHB was higher during hypocalcaemia than during normocalcaemia.</description><identifier>ISSN: 0958-0670</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1111/j.1469-445X.1999.01841.x</identifier><identifier>PMID: 10481228</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>3-Hydroxybutyric Acid - blood ; 3-Hydroxybutyric Acid - metabolism ; 3-Hydroxybutyric Acid - pharmacology ; Animals ; Blood Glucose ; Calcitriol - deficiency ; Calcitriol - genetics ; Calcium - blood ; Disease Models, Animal ; Edetic Acid - pharmacology ; Glucose - metabolism ; Hypocalcemia - chemically induced ; Hypocalcemia - genetics ; Hypocalcemia - metabolism ; Ketone Bodies - metabolism ; Swine - metabolism</subject><ispartof>Experimental physiology, 1999-07, Vol.84 (4), p.707-723</ispartof><rights>The Physiological Society 1999</rights><rights>1999 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4621-a7174cf68a5b23eebc84d0ca71a3494663e132934c6a0c9fc0d69488be60cad23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1469-445X.1999.01841.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1469-445X.1999.01841.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10481228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHLUMBOHM, C.</creatorcontrib><creatorcontrib>HARMEYER, J.</creatorcontrib><title>EFFECT OF HYPOCALCAEMIA ON GLUCOSE METABOLISM IN HYPERKETONAEMIC PIGLETS</title><title>Experimental physiology</title><addtitle>Exp. physiol</addtitle><description>In nine 2- to 3-month-old hyperketonaemic piglets the kinetics of glucose and D-[beta]-hydroxybutyrate (D-BHB) metabolism were studied during hypo- and normocalcaemia in paired experiments. Hyperketonaemia (1á3 and 2á5 mmol D-BHB (l plasma)-1) was generated by a stepwise increase of DL-BHB infusion. Hypocalcaemia spontaneously developed in five piglets due to an inherited calcitriol deficiency and was induced in four control piglets by a continuous infusion of Na2-EDTA. The method of single isotopic marker injections of glucose and D-BHB was used to calculate replacement rates, rate constants and half-lives of glucose and D-BHB in plasma. When DL-BHB was infused at the same rate into normo- and hypocalcaemic piglets, hypocalcaemia reduced the rate constant of glucose by 20-30 % and the replacement rate of glucose by 34 %. In the presence of hyperketonaemia, hypocalcaemia increased the rate of replacement of D-BHB by 6-40 %. The replacement rate represents the sum of endogenous production and the rate of DL-BHB infusion. This observation shows that the endogenous production of D-BHB was higher during hypocalcaemia than during normocalcaemia.</description><subject>3-Hydroxybutyric Acid - blood</subject><subject>3-Hydroxybutyric Acid - metabolism</subject><subject>3-Hydroxybutyric Acid - pharmacology</subject><subject>Animals</subject><subject>Blood Glucose</subject><subject>Calcitriol - deficiency</subject><subject>Calcitriol - genetics</subject><subject>Calcium - blood</subject><subject>Disease Models, Animal</subject><subject>Edetic Acid - pharmacology</subject><subject>Glucose - metabolism</subject><subject>Hypocalcemia - chemically induced</subject><subject>Hypocalcemia - genetics</subject><subject>Hypocalcemia - metabolism</subject><subject>Ketone Bodies - metabolism</subject><subject>Swine - metabolism</subject><issn>0958-0670</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFv2jAYhq1qU0u7_oUpp2mXZHZiHHvSDjRyIGogqKTSdvqUOKYEQUNjEOXfz2nQ1Fvniy37eV_rexByCPaIXT_WHqFMuJQOf3tECOFhwinxXi_Q4N_DJzTAYshdzEJ8ha6NWWNMAszpJboimHLi-3yAJjKOZZQ7WexM_syzaJRGIzlNRk42c8bpY5QtpDOV-eguS5PF1ElmHSYf7mWezTowcubJOJX54gv6vCw2Rt-e9xv0GMs8mrhpNk5sraso84lbhCSkasl4MSz9QOtScVphZa-LgArKWKBJ4IuAKlZgJZYKV0xQzkvNLFX5wQ363vfu2ubloM0etrVRerMpnnVzMEC4IHyIfSosyntUtY0xrV7Crq23RXsCgqHzCGvodEGnCzqP8OYRXm306_mXQ7nV1btgL84Cv3rgWG_06b-LQc4n3cnmv_X5Vf20Otatht3qZOrGNKrW-xNwChRCHFrw53mIYlu2dfWkYd0c2mfr-OMx_gLGF5n4</recordid><startdate>199907</startdate><enddate>199907</enddate><creator>SCHLUMBOHM, C.</creator><creator>HARMEYER, J.</creator><general>Cambridge University Press</general><general>The Physiological Society</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>199907</creationdate><title>EFFECT OF HYPOCALCAEMIA ON GLUCOSE METABOLISM IN HYPERKETONAEMIC PIGLETS</title><author>SCHLUMBOHM, C. ; HARMEYER, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4621-a7174cf68a5b23eebc84d0ca71a3494663e132934c6a0c9fc0d69488be60cad23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>3-Hydroxybutyric Acid - blood</topic><topic>3-Hydroxybutyric Acid - metabolism</topic><topic>3-Hydroxybutyric Acid - pharmacology</topic><topic>Animals</topic><topic>Blood Glucose</topic><topic>Calcitriol - deficiency</topic><topic>Calcitriol - genetics</topic><topic>Calcium - blood</topic><topic>Disease Models, Animal</topic><topic>Edetic Acid - pharmacology</topic><topic>Glucose - metabolism</topic><topic>Hypocalcemia - chemically induced</topic><topic>Hypocalcemia - genetics</topic><topic>Hypocalcemia - metabolism</topic><topic>Ketone Bodies - metabolism</topic><topic>Swine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHLUMBOHM, C.</creatorcontrib><creatorcontrib>HARMEYER, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHLUMBOHM, C.</au><au>HARMEYER, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF HYPOCALCAEMIA ON GLUCOSE METABOLISM IN HYPERKETONAEMIC PIGLETS</atitle><jtitle>Experimental physiology</jtitle><addtitle>Exp. physiol</addtitle><date>1999-07</date><risdate>1999</risdate><volume>84</volume><issue>4</issue><spage>707</spage><epage>723</epage><pages>707-723</pages><issn>0958-0670</issn><eissn>1469-445X</eissn><abstract>In nine 2- to 3-month-old hyperketonaemic piglets the kinetics of glucose and D-[beta]-hydroxybutyrate (D-BHB) metabolism were studied during hypo- and normocalcaemia in paired experiments. Hyperketonaemia (1á3 and 2á5 mmol D-BHB (l plasma)-1) was generated by a stepwise increase of DL-BHB infusion. Hypocalcaemia spontaneously developed in five piglets due to an inherited calcitriol deficiency and was induced in four control piglets by a continuous infusion of Na2-EDTA. The method of single isotopic marker injections of glucose and D-BHB was used to calculate replacement rates, rate constants and half-lives of glucose and D-BHB in plasma. When DL-BHB was infused at the same rate into normo- and hypocalcaemic piglets, hypocalcaemia reduced the rate constant of glucose by 20-30 % and the replacement rate of glucose by 34 %. In the presence of hyperketonaemia, hypocalcaemia increased the rate of replacement of D-BHB by 6-40 %. The replacement rate represents the sum of endogenous production and the rate of DL-BHB infusion. This observation shows that the endogenous production of D-BHB was higher during hypocalcaemia than during normocalcaemia.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>10481228</pmid><doi>10.1111/j.1469-445X.1999.01841.x</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0958-0670 |
| ispartof | Experimental physiology, 1999-07, Vol.84 (4), p.707-723 |
| issn | 0958-0670 1469-445X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1891850249 |
| source | MEDLINE; Access via Wiley Online Library; Wiley Online Library (Open Access Collection) |
| subjects | 3-Hydroxybutyric Acid - blood 3-Hydroxybutyric Acid - metabolism 3-Hydroxybutyric Acid - pharmacology Animals Blood Glucose Calcitriol - deficiency Calcitriol - genetics Calcium - blood Disease Models, Animal Edetic Acid - pharmacology Glucose - metabolism Hypocalcemia - chemically induced Hypocalcemia - genetics Hypocalcemia - metabolism Ketone Bodies - metabolism Swine - metabolism |
| title | EFFECT OF HYPOCALCAEMIA ON GLUCOSE METABOLISM IN HYPERKETONAEMIC PIGLETS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T07%3A46%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=EFFECT%20OF%20HYPOCALCAEMIA%20ON%20GLUCOSE%20METABOLISM%20IN%20HYPERKETONAEMIC%20PIGLETS&rft.jtitle=Experimental%20physiology&rft.au=SCHLUMBOHM,%20C.&rft.date=1999-07&rft.volume=84&rft.issue=4&rft.spage=707&rft.epage=723&rft.pages=707-723&rft.issn=0958-0670&rft.eissn=1469-445X&rft_id=info:doi/10.1111/j.1469-445X.1999.01841.x&rft_dat=%3Cproquest_cross%3E1891850249%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1891850249&rft_id=info:pmid/10481228&rft_cupid=10_1111_j_1469_445X_1999_01841_x&rfr_iscdi=true |