Diketopyridylryanodine Has Three Concentration-dependent Effects on the Cardiac Calcium-release Channel/Ryanodine Receptor

By interacting with more than one site, ryanoids induce multiple effects on calcium-release channels. To date, the kinetics of interaction of only one of these sites has been characterized. Using C4,C12-diketopyridylryanodine in both [3H]ryanodine binding and single channel experiments we characteri...

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Veröffentlicht in:	The Journal of biological chemistry 2003-04, Vol.278 (16), p.14237-14248
Hauptverfasser:	Bidasee, Keshore R., Xu, Le, Meissner, Gerhard, Besch, Henry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Binding Sites Calcium - metabolism diketopyridylryanodine Dogs Dose-Response Relationship, Drug Inhibitory Concentration 50 Kinetics Ligands Models, Chemical Models, Molecular Myocardium - metabolism Protein Binding Ryanodine - analogs & derivatives Ryanodine - chemistry Ryanodine - metabolism Ryanodine - pharmacology Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - metabolism Time Factors
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