The mTORC2/PKC pathway sustains compensatory insulin secretion of pancreatic β cells in response to metabolic stress

Compensation of the pancreatic β cell functional mass in response to metabolic stress is key to the pathogenesis of Type 2 Diabetes. The mTORC2 pathway governs fuel metabolism and β cell functional mass. It is unknown whether mTORC2 is required for regulating metabolic stress-induced β cell compensa...

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Veröffentlicht in:	Biochimica et biophysica acta. General subjects 2017-08, Vol.1861 (8), p.2039-2047
Hauptverfasser:	Xie, Yun, Cui, Canqi, Nie, Aifang, Wang, Yan, Ni, Qicheng, Liu, Yun, Yin, Qinglei, Zhang, Hongli, Li, Yong, Wang, Qidi, Gu, Yanyun, Ning, Guang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Type 2 - etiology Diet, High-Fat High-fat diet Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - metabolism Mechanistic Target of Rapamycin Complex 2 Mice Mice, Inbred C57BL Mice, Knockout mTORC2 Multiprotein Complexes - physiology PKC Protein Kinase C-alpha - physiology Signal Transduction - physiology Stress, Physiological - physiology Tetradecanoylphorbol Acetate - pharmacology TOR Serine-Threonine Kinases - physiology Type 2 Diabetes β cell
Online-Zugang:	Volltext
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