The role of macrophages in the pathogenesis of mycosis fungoides
Summary Background Macrophages are classified into classically activated (M1) and alternatively activated (M2) macrophages. Decrease in macrophage number in tumour tissue with treatment has been reported. Aim The aim of this study was to determine whether treatment has an effect on the number of der...
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| Veröffentlicht in: | Clinical and experimental dermatology 2017-07, Vol.42 (5), p.496-502 |
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| container_title | Clinical and experimental dermatology |
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| creator | Kara, D. Ö. Özsaraç, K. Ç. Uzar, M. K. Bozdoğan, Ö. Gündüz, Ö. |
| description | Summary
Background
Macrophages are classified into classically activated (M1) and alternatively activated (M2) macrophages. Decrease in macrophage number in tumour tissue with treatment has been reported.
Aim
The aim of this study was to determine whether treatment has an effect on the number of dermal M1 and M2 macrophages in patients with mycosis fungoides (MF).
Methods
In total, 21 patients (8 women, 13 men; age range 42–73 years) were included in this study. We determined markers for dermal M1 (inducible nitric oxide synthase and CD68) and M2 (markers: CD163 and CD206) macrophages using double immunohistochemistry to reduce the error rate, and then counted the cells.
Results
The number of dermal M1 cells was significantly lower pretreatment compared with post‐treatment (P < 0.01). The numbers of dermal M2 cells were also numerically decreased by treatment. These results did not change significantly after exclusion of the patients who had recurrence (n = 2). There were no statistically significant differences between groups classified by stage, lesion type or treatment outcome.
Conclusion
Macrophage numbers are decreased in MF after treatment of tumour tissue. |
| doi_str_mv | 10.1111/ced.13090 |
| format | Article |
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Background
Macrophages are classified into classically activated (M1) and alternatively activated (M2) macrophages. Decrease in macrophage number in tumour tissue with treatment has been reported.
Aim
The aim of this study was to determine whether treatment has an effect on the number of dermal M1 and M2 macrophages in patients with mycosis fungoides (MF).
Methods
In total, 21 patients (8 women, 13 men; age range 42–73 years) were included in this study. We determined markers for dermal M1 (inducible nitric oxide synthase and CD68) and M2 (markers: CD163 and CD206) macrophages using double immunohistochemistry to reduce the error rate, and then counted the cells.
Results
The number of dermal M1 cells was significantly lower pretreatment compared with post‐treatment (P < 0.01). The numbers of dermal M2 cells were also numerically decreased by treatment. These results did not change significantly after exclusion of the patients who had recurrence (n = 2). There were no statistically significant differences between groups classified by stage, lesion type or treatment outcome.
Conclusion
Macrophage numbers are decreased in MF after treatment of tumour tissue.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/ced.13090</identifier><identifier>PMID: 28436576</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Aged ; Antigens, CD - metabolism ; Antigens, Differentiation, Myelomonocytic - metabolism ; Biomarkers - metabolism ; Biopsy ; CD163 antigen ; Female ; Fungal infections ; Humans ; Immunohistochemistry ; Macrophages ; Macrophages - drug effects ; Macrophages - metabolism ; Male ; Middle Aged ; Mycosis ; Mycosis fungoides ; Mycosis Fungoides - drug therapy ; Mycosis Fungoides - metabolism ; Nitric oxide ; Nitric Oxide Synthase Type II - metabolism ; Nitric-oxide synthase ; PUVA Therapy ; Skin ; Skin - metabolism ; Statistical analysis ; Tumors</subject><ispartof>Clinical and experimental dermatology, 2017-07, Vol.42 (5), p.496-502</ispartof><rights>2017 British Association of Dermatologists</rights><rights>2017 British Association of Dermatologists.</rights><rights>Copyright © 2017 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-50b19b8160e7036970ca9dc2c7f84bc3572187dde13e316c76e6c0c9029b98eb3</citedby><cites>FETCH-LOGICAL-c3530-50b19b8160e7036970ca9dc2c7f84bc3572187dde13e316c76e6c0c9029b98eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28436576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kara, D. Ö.</creatorcontrib><creatorcontrib>Özsaraç, K. Ç.</creatorcontrib><creatorcontrib>Uzar, M. K.</creatorcontrib><creatorcontrib>Bozdoğan, Ö.</creatorcontrib><creatorcontrib>Gündüz, Ö.</creatorcontrib><title>The role of macrophages in the pathogenesis of mycosis fungoides</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Background
Macrophages are classified into classically activated (M1) and alternatively activated (M2) macrophages. Decrease in macrophage number in tumour tissue with treatment has been reported.
Aim
The aim of this study was to determine whether treatment has an effect on the number of dermal M1 and M2 macrophages in patients with mycosis fungoides (MF).
Methods
In total, 21 patients (8 women, 13 men; age range 42–73 years) were included in this study. We determined markers for dermal M1 (inducible nitric oxide synthase and CD68) and M2 (markers: CD163 and CD206) macrophages using double immunohistochemistry to reduce the error rate, and then counted the cells.
Results
The number of dermal M1 cells was significantly lower pretreatment compared with post‐treatment (P < 0.01). The numbers of dermal M2 cells were also numerically decreased by treatment. These results did not change significantly after exclusion of the patients who had recurrence (n = 2). There were no statistically significant differences between groups classified by stage, lesion type or treatment outcome.
Conclusion
Macrophage numbers are decreased in MF after treatment of tumour tissue.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, CD - metabolism</subject><subject>Antigens, Differentiation, Myelomonocytic - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Biopsy</subject><subject>CD163 antigen</subject><subject>Female</subject><subject>Fungal infections</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Macrophages</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mycosis</subject><subject>Mycosis fungoides</subject><subject>Mycosis Fungoides - drug therapy</subject><subject>Mycosis Fungoides - metabolism</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Nitric-oxide synthase</subject><subject>PUVA Therapy</subject><subject>Skin</subject><subject>Skin - metabolism</subject><subject>Statistical analysis</subject><subject>Tumors</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1Lw0AQhhdRbK0e_AMS8KKHtLPZZj9uSq0fUPBSz0uymbQpSTZmG6T_3m3TXgTnMsPuw8PMS8gthTH1NTGYjSkDBWdkSBmPwyhicE6GwECEXDE5IFfObQAooyK-JINITj0m-JA8LdcYtLbEwOZBlZjWNutkhS4o6mDrv5pku7YrrNEV7oDsjN2PeVevbJGhuyYXeVI6vDn2Efl6nS9n7-Hi8-1j9rwIDYsZhDGkVKWSckABjCsBJlGZiYzI5TT1jIioFFmGlCGj3AiO3IBREKlUSUzZiDz03qa13x26ra4KZ7Askxpt5zSVik69xdtH5P4PurFdW_vtNFXUG2WkYk899pS_2bkWc920RZW0O01B72PVPlZ9iNWzd0djl1b-9USecvTApAd-ihJ3_5v0bP7SK38BFg9-5g</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Kara, D. Ö.</creator><creator>Özsaraç, K. Ç.</creator><creator>Uzar, M. K.</creator><creator>Bozdoğan, Ö.</creator><creator>Gündüz, Ö.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>The role of macrophages in the pathogenesis of mycosis fungoides</title><author>Kara, D. Ö. ; Özsaraç, K. Ç. ; Uzar, M. K. ; Bozdoğan, Ö. ; Gündüz, Ö.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-50b19b8160e7036970ca9dc2c7f84bc3572187dde13e316c76e6c0c9029b98eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens, CD - metabolism</topic><topic>Antigens, Differentiation, Myelomonocytic - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Biopsy</topic><topic>CD163 antigen</topic><topic>Female</topic><topic>Fungal infections</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Macrophages</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mycosis</topic><topic>Mycosis fungoides</topic><topic>Mycosis Fungoides - drug therapy</topic><topic>Mycosis Fungoides - metabolism</topic><topic>Nitric oxide</topic><topic>Nitric Oxide Synthase Type II - metabolism</topic><topic>Nitric-oxide synthase</topic><topic>PUVA Therapy</topic><topic>Skin</topic><topic>Skin - metabolism</topic><topic>Statistical analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kara, D. Ö.</creatorcontrib><creatorcontrib>Özsaraç, K. Ç.</creatorcontrib><creatorcontrib>Uzar, M. K.</creatorcontrib><creatorcontrib>Bozdoğan, Ö.</creatorcontrib><creatorcontrib>Gündüz, Ö.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kara, D. Ö.</au><au>Özsaraç, K. Ç.</au><au>Uzar, M. K.</au><au>Bozdoğan, Ö.</au><au>Gündüz, Ö.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of macrophages in the pathogenesis of mycosis fungoides</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2017-07</date><risdate>2017</risdate><volume>42</volume><issue>5</issue><spage>496</spage><epage>502</epage><pages>496-502</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><abstract>Summary
Background
Macrophages are classified into classically activated (M1) and alternatively activated (M2) macrophages. Decrease in macrophage number in tumour tissue with treatment has been reported.
Aim
The aim of this study was to determine whether treatment has an effect on the number of dermal M1 and M2 macrophages in patients with mycosis fungoides (MF).
Methods
In total, 21 patients (8 women, 13 men; age range 42–73 years) were included in this study. We determined markers for dermal M1 (inducible nitric oxide synthase and CD68) and M2 (markers: CD163 and CD206) macrophages using double immunohistochemistry to reduce the error rate, and then counted the cells.
Results
The number of dermal M1 cells was significantly lower pretreatment compared with post‐treatment (P < 0.01). The numbers of dermal M2 cells were also numerically decreased by treatment. These results did not change significantly after exclusion of the patients who had recurrence (n = 2). There were no statistically significant differences between groups classified by stage, lesion type or treatment outcome.
Conclusion
Macrophage numbers are decreased in MF after treatment of tumour tissue.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>28436576</pmid><doi>10.1111/ced.13090</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinical and experimental dermatology, 2017-07, Vol.42 (5), p.496-502 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Aged Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Biomarkers - metabolism Biopsy CD163 antigen Female Fungal infections Humans Immunohistochemistry Macrophages Macrophages - drug effects Macrophages - metabolism Male Middle Aged Mycosis Mycosis fungoides Mycosis Fungoides - drug therapy Mycosis Fungoides - metabolism Nitric oxide Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase PUVA Therapy Skin Skin - metabolism Statistical analysis Tumors |
| title | The role of macrophages in the pathogenesis of mycosis fungoides |
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