Elevated Plasma S100B, Psychotic Symptoms, and Cognition in Schizophrenia
S100B is a calcium binding protein mainly produced by glial cells. Previous studies have shown elevated levels of S100B in patients with schizophrenia. We measured S100B levels in fasting plasma of 39 patients with schizophrenia and 19 adult healthy controls. We used linear regression to compare S10...
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| Veröffentlicht in: | Psychiatric quarterly 2018-03, Vol.89 (1), p.53-60 |
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| creator | Deng, Huiqiong Kahlon, Ramandeep S. Mohite, Satyajit Amin, Pooja A. Zunta-Soares, Giovana Colpo, Gabriela D. Stertz, Laura Fries, Gabriel R. Walss-Bass, Consuelo Soares, Jair C. Okusaga, Olaoluwa O. |
| description | S100B is a calcium binding protein mainly produced by glial cells. Previous studies have shown elevated levels of S100B in patients with schizophrenia. We measured S100B levels in fasting plasma of 39 patients with schizophrenia and 19 adult healthy controls. We used linear regression to compare S100B between patients and controls. In patients only, we also investigated the relationship between S100B levels and psychotic symptoms (assessed by the Positive and Negative Syndrome Scale), and cognitive function (assessed by the NIH Toolbox Cognition Battery), respectively by calculating Pearson’s correlation coefficients. Mean plasma S100B was significantly higher in the patient group than in the control group. There were no significant correlations between plasma S100B and psychotic symptoms or cognition. |
| doi_str_mv | 10.1007/s11126-017-9514-y |
| format | Article |
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Previous studies have shown elevated levels of S100B in patients with schizophrenia. We measured S100B levels in fasting plasma of 39 patients with schizophrenia and 19 adult healthy controls. We used linear regression to compare S100B between patients and controls. In patients only, we also investigated the relationship between S100B levels and psychotic symptoms (assessed by the Positive and Negative Syndrome Scale), and cognitive function (assessed by the NIH Toolbox Cognition Battery), respectively by calculating Pearson’s correlation coefficients. Mean plasma S100B was significantly higher in the patient group than in the control group. There were no significant correlations between plasma S100B and psychotic symptoms or cognition.</description><identifier>ISSN: 0033-2720</identifier><identifier>EISSN: 1573-6709</identifier><identifier>DOI: 10.1007/s11126-017-9514-y</identifier><identifier>PMID: 28435992</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Calcium ; Calcium-binding protein ; Cognition ; Cognition & reasoning ; Cognitive ability ; Cognitive Dysfunction - blood ; Cognitive functioning ; Fasting ; Female ; Glial cells ; Humans ; Male ; Medicine ; Medicine & Public Health ; Mental disorders ; Middle Aged ; Original Paper ; Plasma ; Psychiatry ; Psychosis ; Psychotic Disorders - blood ; Psychotic symptoms ; Public Health ; S100 Calcium Binding Protein beta Subunit - blood ; S100b protein ; Schizophrenia ; Schizophrenia - blood ; Sociology</subject><ispartof>Psychiatric quarterly, 2018-03, Vol.89 (1), p.53-60</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>Psychiatric Quarterly is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-a058f447deb9ee1193b5acf9dd68e28a34edb22d69ccad984a7303b8fcb35def3</citedby><cites>FETCH-LOGICAL-c372t-a058f447deb9ee1193b5acf9dd68e28a34edb22d69ccad984a7303b8fcb35def3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11126-017-9514-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11126-017-9514-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,12846,27924,27925,30999,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28435992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Huiqiong</creatorcontrib><creatorcontrib>Kahlon, Ramandeep S.</creatorcontrib><creatorcontrib>Mohite, Satyajit</creatorcontrib><creatorcontrib>Amin, Pooja A.</creatorcontrib><creatorcontrib>Zunta-Soares, Giovana</creatorcontrib><creatorcontrib>Colpo, Gabriela D.</creatorcontrib><creatorcontrib>Stertz, Laura</creatorcontrib><creatorcontrib>Fries, Gabriel R.</creatorcontrib><creatorcontrib>Walss-Bass, Consuelo</creatorcontrib><creatorcontrib>Soares, Jair C.</creatorcontrib><creatorcontrib>Okusaga, Olaoluwa O.</creatorcontrib><title>Elevated Plasma S100B, Psychotic Symptoms, and Cognition in Schizophrenia</title><title>Psychiatric quarterly</title><addtitle>Psychiatr Q</addtitle><addtitle>Psychiatr Q</addtitle><description>S100B is a calcium binding protein mainly produced by glial cells. Previous studies have shown elevated levels of S100B in patients with schizophrenia. We measured S100B levels in fasting plasma of 39 patients with schizophrenia and 19 adult healthy controls. We used linear regression to compare S100B between patients and controls. In patients only, we also investigated the relationship between S100B levels and psychotic symptoms (assessed by the Positive and Negative Syndrome Scale), and cognitive function (assessed by the NIH Toolbox Cognition Battery), respectively by calculating Pearson’s correlation coefficients. Mean plasma S100B was significantly higher in the patient group than in the control group. There were no significant correlations between plasma S100B and psychotic symptoms or cognition.</description><subject>Adult</subject><subject>Calcium</subject><subject>Calcium-binding protein</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - blood</subject><subject>Cognitive functioning</subject><subject>Fasting</subject><subject>Female</subject><subject>Glial cells</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Plasma</subject><subject>Psychiatry</subject><subject>Psychosis</subject><subject>Psychotic Disorders - blood</subject><subject>Psychotic symptoms</subject><subject>Public Health</subject><subject>S100 Calcium Binding Protein beta Subunit - blood</subject><subject>S100b protein</subject><subject>Schizophrenia</subject><subject>Schizophrenia - 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Academic</collection><jtitle>Psychiatric quarterly</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Huiqiong</au><au>Kahlon, Ramandeep S.</au><au>Mohite, Satyajit</au><au>Amin, Pooja A.</au><au>Zunta-Soares, Giovana</au><au>Colpo, Gabriela D.</au><au>Stertz, Laura</au><au>Fries, Gabriel R.</au><au>Walss-Bass, Consuelo</au><au>Soares, Jair C.</au><au>Okusaga, Olaoluwa O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Plasma S100B, Psychotic Symptoms, and Cognition in Schizophrenia</atitle><jtitle>Psychiatric quarterly</jtitle><stitle>Psychiatr Q</stitle><addtitle>Psychiatr Q</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>89</volume><issue>1</issue><spage>53</spage><epage>60</epage><pages>53-60</pages><issn>0033-2720</issn><eissn>1573-6709</eissn><abstract>S100B is a calcium binding protein mainly produced by glial cells. Previous studies have shown elevated levels of S100B in patients with schizophrenia. We measured S100B levels in fasting plasma of 39 patients with schizophrenia and 19 adult healthy controls. We used linear regression to compare S100B between patients and controls. In patients only, we also investigated the relationship between S100B levels and psychotic symptoms (assessed by the Positive and Negative Syndrome Scale), and cognitive function (assessed by the NIH Toolbox Cognition Battery), respectively by calculating Pearson’s correlation coefficients. Mean plasma S100B was significantly higher in the patient group than in the control group. There were no significant correlations between plasma S100B and psychotic symptoms or cognition.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28435992</pmid><doi>10.1007/s11126-017-9514-y</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Calcium Calcium-binding protein Cognition Cognition & reasoning Cognitive ability Cognitive Dysfunction - blood Cognitive functioning Fasting Female Glial cells Humans Male Medicine Medicine & Public Health Mental disorders Middle Aged Original Paper Plasma Psychiatry Psychosis Psychotic Disorders - blood Psychotic symptoms Public Health S100 Calcium Binding Protein beta Subunit - blood S100b protein Schizophrenia Schizophrenia - blood Sociology |
| title | Elevated Plasma S100B, Psychotic Symptoms, and Cognition in Schizophrenia |
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