Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum

Abstract Previously, we have shown that the N -methyl d -aspartate (NMDA)-receptor antagonist kynurenic acid (KYNA) and its analogue KYNA1 do not bind directly to mu, kappa and delta opioid receptors in vitro . On the other hand, chronic administration of KYNA and KYNA1 resulted in region (cortex vs...

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Veröffentlicht in:	Journal of the neurological sciences 2017-05, Vol.376, p.63-70
Hauptverfasser:	Samavati, Reza, Zádor, Ferenc, Szűcs, Edina, Tuka, Bernadett, Martos, Diána, Veres, Gábor, Gáspár, Róbert, Mándity, István, Fülöp, Ferenc, Vécsei, László, Benyhe, Sándor, Borsodi, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	[35S]GTPγS binding Animals Cell Membrane - drug effects Cell Membrane - metabolism Central Nervous System Agents - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Chromatography, High Pressure Liquid Corpus Striatum - drug effects Corpus Striatum - metabolism Dizocilpine Maleate - pharmacology G-protein GTP-Binding Proteins - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - metabolism KYNA Kynurenic Acid - analogs & derivatives Kynurenic Acid - metabolism Kynurenic Acid - pharmacology Male MK-801 Neurology Opioid receptor Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism Receptors, Opioid - agonists Receptors, Opioid - metabolism Tissue Culture Techniques
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