Rates and predictors of hospital readmission after transcatheter aortic valve implantation

To analyse reasons, timing and predictors of hospital readmissions after transcatheter aortic valve implantation (TAVI). Patients included in the Bern TAVI Registry between August 2007 and June 2014 were analysed. Fine and Gray competing risk regression was used to identify factors predictive of hos...

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Veröffentlicht in:European heart journal 2017-07, Vol.38 (28), p.2211-2217
Hauptverfasser: Franzone, Anna, Pilgrim, Thomas, Arnold, Nicolas, Heg, Dik, Langhammer, Bettina, Piccolo, Raffaele, Roost, Eva, Praz, Fabien, Räber, Lorenz, Valgimigli, Marco, Wenaweser, Peter, Jüni, Peter, Carrel, Thierry, Windecker, Stephan, Stortecky, Stefan
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container_end_page 2217
container_issue 28
container_start_page 2211
container_title European heart journal
container_volume 38
creator Franzone, Anna
Pilgrim, Thomas
Arnold, Nicolas
Heg, Dik
Langhammer, Bettina
Piccolo, Raffaele
Roost, Eva
Praz, Fabien
Räber, Lorenz
Valgimigli, Marco
Wenaweser, Peter
Jüni, Peter
Carrel, Thierry
Windecker, Stephan
Stortecky, Stefan
description To analyse reasons, timing and predictors of hospital readmissions after transcatheter aortic valve implantation (TAVI). Patients included in the Bern TAVI Registry between August 2007 and June 2014 were analysed. Fine and Gray competing risk regression was used to identify factors predictive of hospital readmission within 1 year after TAVI with bootstrap analysis for internal validation. Of 868 patients alive at discharge, 221 (25.4%) were readmitted within 1 year. Compared with patients not requiring readmission, those with at least one readmission more frequently were male and more often had atrial fibrillation and higher creatinine values (P 
doi_str_mv 10.1093/eurheartj/ehx182
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Patients included in the Bern TAVI Registry between August 2007 and June 2014 were analysed. Fine and Gray competing risk regression was used to identify factors predictive of hospital readmission within 1 year after TAVI with bootstrap analysis for internal validation. Of 868 patients alive at discharge, 221 (25.4%) were readmitted within 1 year. Compared with patients not requiring readmission, those with at least one readmission more frequently were male and more often had atrial fibrillation and higher creatinine values (P &lt; 0.05 for all cases). For overall 308 readmissions, cardiovascular causes accounted for 46.1% with heart failure as the most frequent indication; non-cardiovascular readmissions occurred for surgery (11.7%), gastrointestinal disorders (9.7%), malignancy (4.9%), respiratory diseases (4.6%) and chronic kidney failure (2.6%). Male gender (subhazard ratio, SHR, 1.33, 95% confidence intervals, CI, 1.02-1.73, P = 0.035) and stage 3 kidney injury (SHR 2.04, 95% CI 1.12-3.71, P = 0.021) were found independent risk factors for any hospital readmission, whereas previous myocardial infarction (SHR 1.88, 95% CI 1.22-2.90, P = 0.004) and in-hospital life-threatening bleeding (SHR 2.18, 95%CI 1.24-3.85, P = 0.007) were associated with cardiovascular readmissions. The event rate for mortality was significantly increased after readmissions for any cause (RR 4.29, 95% CI 2.86-6.42, P &lt; 0.001). Hospital readmission was observed in one out of four patients during the first year after TAVI and was associated with a significant increase in mortality.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehx182</identifier><identifier>PMID: 28430920</identifier><language>eng</language><publisher>England</publisher><subject>Acute Kidney Injury - etiology ; Acute Kidney Injury - mortality ; Aged, 80 and over ; Aortic Valve Stenosis - mortality ; Aortic Valve Stenosis - surgery ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Female ; Humans ; Length of Stay ; Male ; Patient Readmission - statistics &amp; numerical data ; Postoperative Complications - etiology ; Prognosis ; Prospective Studies ; Registries ; Regression Analysis ; Switzerland - epidemiology ; Transcatheter Aortic Valve Replacement</subject><ispartof>European heart journal, 2017-07, Vol.38 (28), p.2211-2217</ispartof><rights>Published on behalf of the European Society of Cardiology. 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Male gender (subhazard ratio, SHR, 1.33, 95% confidence intervals, CI, 1.02-1.73, P = 0.035) and stage 3 kidney injury (SHR 2.04, 95% CI 1.12-3.71, P = 0.021) were found independent risk factors for any hospital readmission, whereas previous myocardial infarction (SHR 1.88, 95% CI 1.22-2.90, P = 0.004) and in-hospital life-threatening bleeding (SHR 2.18, 95%CI 1.24-3.85, P = 0.007) were associated with cardiovascular readmissions. The event rate for mortality was significantly increased after readmissions for any cause (RR 4.29, 95% CI 2.86-6.42, P &lt; 0.001). 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Patients included in the Bern TAVI Registry between August 2007 and June 2014 were analysed. Fine and Gray competing risk regression was used to identify factors predictive of hospital readmission within 1 year after TAVI with bootstrap analysis for internal validation. Of 868 patients alive at discharge, 221 (25.4%) were readmitted within 1 year. Compared with patients not requiring readmission, those with at least one readmission more frequently were male and more often had atrial fibrillation and higher creatinine values (P &lt; 0.05 for all cases). For overall 308 readmissions, cardiovascular causes accounted for 46.1% with heart failure as the most frequent indication; non-cardiovascular readmissions occurred for surgery (11.7%), gastrointestinal disorders (9.7%), malignancy (4.9%), respiratory diseases (4.6%) and chronic kidney failure (2.6%). Male gender (subhazard ratio, SHR, 1.33, 95% confidence intervals, CI, 1.02-1.73, P = 0.035) and stage 3 kidney injury (SHR 2.04, 95% CI 1.12-3.71, P = 0.021) were found independent risk factors for any hospital readmission, whereas previous myocardial infarction (SHR 1.88, 95% CI 1.22-2.90, P = 0.004) and in-hospital life-threatening bleeding (SHR 2.18, 95%CI 1.24-3.85, P = 0.007) were associated with cardiovascular readmissions. The event rate for mortality was significantly increased after readmissions for any cause (RR 4.29, 95% CI 2.86-6.42, P &lt; 0.001). Hospital readmission was observed in one out of four patients during the first year after TAVI and was associated with a significant increase in mortality.</abstract><cop>England</cop><pmid>28430920</pmid><doi>10.1093/eurheartj/ehx182</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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source Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Acute Kidney Injury - etiology
Acute Kidney Injury - mortality
Aged, 80 and over
Aortic Valve Stenosis - mortality
Aortic Valve Stenosis - surgery
Cardiovascular Diseases - etiology
Cardiovascular Diseases - mortality
Female
Humans
Length of Stay
Male
Patient Readmission - statistics & numerical data
Postoperative Complications - etiology
Prognosis
Prospective Studies
Registries
Regression Analysis
Switzerland - epidemiology
Transcatheter Aortic Valve Replacement
title Rates and predictors of hospital readmission after transcatheter aortic valve implantation
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