Oligonucleotide promoted peptide bond formation using a tRNA mimicking approach

Oligonucleotide promoted peptide bond formation using a tRNA mimicking approach

TransferRNA's role in protein translation is the prime example of an Informational Leaving Group (ILG). A simplified model produced oligophenylalanine with a modified uracil as an ILG in the presence of specific oligonucleotides. Our preliminary studies contribute to the importance of hybrid sp...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017-05, Vol.53 (36), p.5013-5016
Hauptverfasser: Mattelaer, H-P, Mattelaer, C-A, Papastavrou, N, Dehaen, W, Herdewijn, P
Format: Artikel
Sprache:eng
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Zusammenfassung:TransferRNA's role in protein translation is the prime example of an Informational Leaving Group (ILG). A simplified model produced oligophenylalanine with a modified uracil as an ILG in the presence of specific oligonucleotides. Our preliminary studies contribute to the importance of hybrid species in bridging the gap between peptides and nucleic acids.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc00831g