Enhanced anti-rheumatic activity of methotrexate-entrapped ultradeformable liposomal gel in adjuvant-induced arthritis rat model

[Display omitted] The aim of this study is to investigate in vivo anti-rheumatic activity of methotrexate-entrapped ultradeformable liposomal gel (MTX-UDLs-gel) in adjuvant-induced arthritis rat model. Methotrexate-entrapped ultradeformable liposomes (MTX-UDLs) with the optimal phosphatidylcholine t...

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Veröffentlicht in:	International journal of pharmaceutics 2017-06, Vol.525 (1), p.92-100
Hauptverfasser:	Zeb, Alam, Qureshi, Omer Salman, Yu, Chan-Hee, Akram, Muhammad, Kim, Hyung-Seo, Kim, Myung-Sic, Kang, Jong-Ho, Majid, Arshad, Chang, Sun-Young, Bae, Ok-Nam, Kim, Jin-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Experimental - drug therapy Arthritis, Rheumatoid Complete Freund’s adjuvant Inflammation Interleukin-1beta - metabolism Liposomes - chemistry Methotrexate Methotrexate - administration & dosage Methotrexate - pharmacology Rats Rheumatoid arthritis Transdermal delivery Tumor Necrosis Factor-alpha - metabolism Ultradeformable liposomes
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