Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model
To investigate the antioxidant and anti‐inflammatory effects of alpha‐lipoic acid (ALA) in the treatment of endometriosis in an experimental rat model by evaluating biochemical and histopathologic parameters. Experimental endometriosis was induced by the peritoneal implantation of autologous endomet...
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| Veröffentlicht in: | Fundamental & clinical pharmacology 2017-10, Vol.31 (5), p.506-512 |
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| creator | Pınar, Neslihan Soylu Karapınar, Oya Özcan, Oğuzhan Özgür, Tümay Bayraktar, Suphi |
| description | To investigate the antioxidant and anti‐inflammatory effects of alpha‐lipoic acid (ALA) in the treatment of endometriosis in an experimental rat model by evaluating biochemical and histopathologic parameters. Experimental endometriosis was induced by the peritoneal implantation of autologous endometrial tissue. The rats were randomly divided into two groups with eight rats each. Group I was intraperitoneally administered ALA 100 mg/kg/day for 14 days. Group II was intraperitoneally administered saline solution at the same dosage and over the same period. Endometrial implant volume was measured in both groups both pre‐ and post‐treatment. Tumor necrosis factor alpha (TNF‐α) was measured in peritoneal fluid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were assessed in serum. The implants were histopathologically evaluated. In the ALA group, the serum TOS and OSI levels, the endometrial implant volumes, the TNF‐α levels in serum and peritoneal fluid, and the histopathologic scores were significantly lower compared to the control group (P < 0.05). Alpha‐lipoic acid may have a therapeutic potential in the treatment of endometriosis due to its antioxidant and anti‐inflammatory effects. |
| doi_str_mv | 10.1111/fcp.12293 |
| format | Article |
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Experimental endometriosis was induced by the peritoneal implantation of autologous endometrial tissue. The rats were randomly divided into two groups with eight rats each. Group I was intraperitoneally administered ALA 100 mg/kg/day for 14 days. Group II was intraperitoneally administered saline solution at the same dosage and over the same period. Endometrial implant volume was measured in both groups both pre‐ and post‐treatment. Tumor necrosis factor alpha (TNF‐α) was measured in peritoneal fluid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were assessed in serum. The implants were histopathologically evaluated. In the ALA group, the serum TOS and OSI levels, the endometrial implant volumes, the TNF‐α levels in serum and peritoneal fluid, and the histopathologic scores were significantly lower compared to the control group (P < 0.05). Alpha‐lipoic acid may have a therapeutic potential in the treatment of endometriosis due to its antioxidant and anti‐inflammatory effects.</description><identifier>ISSN: 0767-3981</identifier><identifier>EISSN: 1472-8206</identifier><identifier>DOI: 10.1111/fcp.12293</identifier><identifier>PMID: 28429826</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>alpha‐lipoic acid ; Animals ; Antioxidants ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Autografts - drug effects ; Autografts - pathology ; Disease Models, Animal ; Dosage ; Endometriosis ; Endometriosis - drug therapy ; Endometriosis - etiology ; Endometriosis - pathology ; Endometrium ; Endometrium - drug effects ; Endometrium - pathology ; Female ; Implantation ; Implants ; Inflammation ; Lipoic acid ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Peritoneal fluid ; Peritoneum ; Pharmacology ; Rats ; Rats, Wistar ; Rodents ; Saline solutions ; TAS ; Thioctic Acid - pharmacology ; Thioctic Acid - therapeutic use ; TNF‐α ; TOS ; Transplants & implants ; Treatment Outcome ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Fundamental & clinical pharmacology, 2017-10, Vol.31 (5), p.506-512</ispartof><rights>2017 Société Française de Pharmacologie et de Thérapeutique</rights><rights>2017 Société Française de Pharmacologie et de Thérapeutique.</rights><rights>Copyright © 2017 Société Française de Pharmacologie et de Thérapeutique</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-ee3d358f6f314dc78fea3a2c33018124002979c16c7a9683cff49cb6bc3467df3</citedby><cites>FETCH-LOGICAL-c3533-ee3d358f6f314dc78fea3a2c33018124002979c16c7a9683cff49cb6bc3467df3</cites><orcidid>0000-0001-5863-9665</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ffcp.12293$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ffcp.12293$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28429826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pınar, Neslihan</creatorcontrib><creatorcontrib>Soylu Karapınar, Oya</creatorcontrib><creatorcontrib>Özcan, Oğuzhan</creatorcontrib><creatorcontrib>Özgür, Tümay</creatorcontrib><creatorcontrib>Bayraktar, Suphi</creatorcontrib><title>Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model</title><title>Fundamental & clinical pharmacology</title><addtitle>Fundam Clin Pharmacol</addtitle><description>To investigate the antioxidant and anti‐inflammatory effects of alpha‐lipoic acid (ALA) in the treatment of endometriosis in an experimental rat model by evaluating biochemical and histopathologic parameters. Experimental endometriosis was induced by the peritoneal implantation of autologous endometrial tissue. The rats were randomly divided into two groups with eight rats each. Group I was intraperitoneally administered ALA 100 mg/kg/day for 14 days. Group II was intraperitoneally administered saline solution at the same dosage and over the same period. Endometrial implant volume was measured in both groups both pre‐ and post‐treatment. Tumor necrosis factor alpha (TNF‐α) was measured in peritoneal fluid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were assessed in serum. The implants were histopathologically evaluated. In the ALA group, the serum TOS and OSI levels, the endometrial implant volumes, the TNF‐α levels in serum and peritoneal fluid, and the histopathologic scores were significantly lower compared to the control group (P < 0.05). Alpha‐lipoic acid may have a therapeutic potential in the treatment of endometriosis due to its antioxidant and anti‐inflammatory effects.</description><subject>alpha‐lipoic acid</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Autografts - drug effects</subject><subject>Autografts - pathology</subject><subject>Disease Models, Animal</subject><subject>Dosage</subject><subject>Endometriosis</subject><subject>Endometriosis - drug therapy</subject><subject>Endometriosis - etiology</subject><subject>Endometriosis - pathology</subject><subject>Endometrium</subject><subject>Endometrium - drug effects</subject><subject>Endometrium - pathology</subject><subject>Female</subject><subject>Implantation</subject><subject>Implants</subject><subject>Inflammation</subject><subject>Lipoic acid</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>Peritoneal fluid</subject><subject>Peritoneum</subject><subject>Pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Saline solutions</subject><subject>TAS</subject><subject>Thioctic Acid - pharmacology</subject><subject>Thioctic Acid - therapeutic use</subject><subject>TNF‐α</subject><subject>TOS</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>0767-3981</issn><issn>1472-8206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKxTAQhoMoerwsfAEJuNFFNZOpabKUgzcQFNF1yEkTjLRNbXpQdz6Cz-iTGD3qQnA2s5iPn38-QraBHUCeQ2_7A-Bc4RKZQFnxQnImlsmEVaIqUElYI-spPTAGFQOxSta4LLmSXEzIzYn3zo40emqa_t68v741oY_BUmNDTWNHXVfH1o1DMA0Nbd-Ybkw0dNTk03PvhtC6bsy3wYy0jbVrNsmKN01yW997g9ydntxOz4vLq7OL6fFlYfEIsXAOazySXniEsraV9M6g4RaRgQReMsZVpSwIWxklJFrvS2VnYmaxFFXtcYPsLXL7IT7OXRp1G5J1TW7o4jxpkAoAMavI6O4f9CHOhy6306CwVFwI4JnaX1B2iCkNzus-f2eGFw1Mf4rWWbT-Ep3Zne_E-ax19S_5YzYDhwvgKTTu5f8kfTq9XkR-AMjZhvs</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Pınar, Neslihan</creator><creator>Soylu Karapınar, Oya</creator><creator>Özcan, Oğuzhan</creator><creator>Özgür, Tümay</creator><creator>Bayraktar, Suphi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5863-9665</orcidid></search><sort><creationdate>201710</creationdate><title>Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model</title><author>Pınar, Neslihan ; Soylu Karapınar, Oya ; Özcan, Oğuzhan ; Özgür, Tümay ; Bayraktar, Suphi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-ee3d358f6f314dc78fea3a2c33018124002979c16c7a9683cff49cb6bc3467df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>alpha‐lipoic acid</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Autografts - drug effects</topic><topic>Autografts - pathology</topic><topic>Disease Models, Animal</topic><topic>Dosage</topic><topic>Endometriosis</topic><topic>Endometriosis - drug therapy</topic><topic>Endometriosis - etiology</topic><topic>Endometriosis - pathology</topic><topic>Endometrium</topic><topic>Endometrium - drug effects</topic><topic>Endometrium - pathology</topic><topic>Female</topic><topic>Implantation</topic><topic>Implants</topic><topic>Inflammation</topic><topic>Lipoic acid</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>Peritoneal fluid</topic><topic>Peritoneum</topic><topic>Pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Saline solutions</topic><topic>TAS</topic><topic>Thioctic Acid - pharmacology</topic><topic>Thioctic Acid - therapeutic use</topic><topic>TNF‐α</topic><topic>TOS</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pınar, Neslihan</creatorcontrib><creatorcontrib>Soylu Karapınar, Oya</creatorcontrib><creatorcontrib>Özcan, Oğuzhan</creatorcontrib><creatorcontrib>Özgür, Tümay</creatorcontrib><creatorcontrib>Bayraktar, Suphi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Fundamental & clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pınar, Neslihan</au><au>Soylu Karapınar, Oya</au><au>Özcan, Oğuzhan</au><au>Özgür, Tümay</au><au>Bayraktar, Suphi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model</atitle><jtitle>Fundamental & clinical pharmacology</jtitle><addtitle>Fundam Clin Pharmacol</addtitle><date>2017-10</date><risdate>2017</risdate><volume>31</volume><issue>5</issue><spage>506</spage><epage>512</epage><pages>506-512</pages><issn>0767-3981</issn><eissn>1472-8206</eissn><abstract>To investigate the antioxidant and anti‐inflammatory effects of alpha‐lipoic acid (ALA) in the treatment of endometriosis in an experimental rat model by evaluating biochemical and histopathologic parameters. Experimental endometriosis was induced by the peritoneal implantation of autologous endometrial tissue. The rats were randomly divided into two groups with eight rats each. Group I was intraperitoneally administered ALA 100 mg/kg/day for 14 days. Group II was intraperitoneally administered saline solution at the same dosage and over the same period. Endometrial implant volume was measured in both groups both pre‐ and post‐treatment. Tumor necrosis factor alpha (TNF‐α) was measured in peritoneal fluid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were assessed in serum. The implants were histopathologically evaluated. In the ALA group, the serum TOS and OSI levels, the endometrial implant volumes, the TNF‐α levels in serum and peritoneal fluid, and the histopathologic scores were significantly lower compared to the control group (P < 0.05). Alpha‐lipoic acid may have a therapeutic potential in the treatment of endometriosis due to its antioxidant and anti‐inflammatory effects.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28429826</pmid><doi>10.1111/fcp.12293</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5863-9665</orcidid></addata></record> |
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| subjects | alpha‐lipoic acid Animals Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Autografts - drug effects Autografts - pathology Disease Models, Animal Dosage Endometriosis Endometriosis - drug therapy Endometriosis - etiology Endometriosis - pathology Endometrium Endometrium - drug effects Endometrium - pathology Female Implantation Implants Inflammation Lipoic acid Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Peritoneal fluid Peritoneum Pharmacology Rats Rats, Wistar Rodents Saline solutions TAS Thioctic Acid - pharmacology Thioctic Acid - therapeutic use TNF‐α TOS Transplants & implants Treatment Outcome Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model |
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