CB1 cannabinoid receptor drives oocyte maturation and embryo development via PI3K/Akt and MAPK pathways

ABSTRACT Endocannabinoids have been recognized as mediators of practically all reproductive events in mammals. However, little is known about the role of this system in oocyte maturation. In a mouse model, we observed that activation of cannabinoid receptor 1 (CB1) during in vitro oocyte maturation...

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Veröffentlicht in:	The FASEB journal 2017-08, Vol.31 (8), p.3372-3382
Hauptverfasser:	López‐Cardona, Angela Patricia, Pérez‐Cerezales, Serafín, Fernández‐González, Raúl, Laguna‐Barraza, Ricardo, Pericuesta, Eva, Agirregoitia, Naiara, Gutiérrez‐Adán, Alfonso, Agirregoitia, Ekaitz
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein assisted reproductive technology Cannabinoid CB1 receptors Cannabinoid CB2 receptors embryology Embryos fertility Gonadotropins In vitro fertilization MAP kinase Maturation Oviduct Phosphorylation Pituitary (anterior)
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