Kinetic reconstruction reveals time-dependent effects of romosozumab on bone formation and osteoblast function in vertebral cancellous and cortical bone in cynomolgus monkeys

Abstract Romosozumab, a humanized monoclonal sclerostin antibody under development for the treatment of osteoporosis, has a unique mechanism of action on bone—increasing bone formation and decreasing bone resorption. The effects on bone formation are transient, eliciting a rapid increase in bone for...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2017-08, Vol.101, p.77-87
Hauptverfasser:	Boyce, Rogely Waite, Niu, Qing-Tian, Ominsky, Michael S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anabolics Animals Antibodies, Monoclonal - pharmacology Bone Bone Density - drug effects Bone Remodeling - drug effects Cancellous Bone - cytology Cancellous Bone - drug effects Cortical Bone - cytology Cortical Bone - drug effects Histomorphometry Macaca fascicularis Male Orthopedics Osteoblasts - cytology Osteoblasts - drug effects Osteogenesis - drug effects Osteoporosis Osteoporosis - metabolism Therapeutics Wnt signaling Wnt Signaling Pathway - drug effects
Online-Zugang:	Volltext
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