Impact of Acid‐Reducing Agents on the Pharmacokinetics of Palbociclib, a Weak Base With pH‐Dependent Solubility, With Different Food Intake Conditions

Palbociclib free base capsule is a weak base drug with highly pH‐dependent solubility. In vitro and in vivo studies evaluated the impact of acid‐reducing agents on exposure of palbociclib and determined whether the impact, if any, can be mitigated by food. A drug‐drug interaction study (study 1) was...

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Veröffentlicht in:	Clinical pharmacology in drug development 2017-11, Vol.6 (6), p.614-626
Hauptverfasser:	Sun, Wan, Klamerus, Karen J., Yuhas, Lisa M., Pawlak, Sylvester, Plotka, Anna, O'Gorman, Melissa, Kirkovsky, Leonid, Kosa, Maha, Wang, Diane
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids acid‐reducing agent Adult Antacids - administration & dosage Antacids - pharmacology Area Under Curve Bile Acids and Salts - chemistry Drug Administration Schedule Drug Interactions Famotidine - administration & dosage Famotidine - pharmacology fast condition fed condition Female Food Food-Drug Interactions free base capsule Histamine H2 Antagonists - administration & dosage Histamine H2 Antagonists - pharmacology histamine‐2 receptor antagonist Humans Hydrogen-Ion Concentration local antacid Male Micelles Middle Aged palbociclib Pharmacokinetics Pharmacology pH‐dependent solubility Piperazines - administration & dosage Piperazines - chemistry Piperazines - pharmacokinetics Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacokinetics proton pump inhibitor Proton Pump Inhibitors - administration & dosage Proton Pump Inhibitors - pharmacology Pyridines - administration & dosage Pyridines - chemistry Pyridines - pharmacokinetics Rabeprazole - administration & dosage Rabeprazole - pharmacology Solubility Young Adult
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