Sickle Cell Disease

Sickle cell disease is caused by an alteration in a single DNA base, but its clinical manifestations are influenced by other genes and behavioral and environmental factors. Recent findings may indicate an acceleration in the discovery of interventions that alter the disease course. Sickle cell disea...

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Veröffentlicht in:	The New England journal of medicine 2017-04, Vol.376 (16), p.1561-1573
Hauptverfasser:	Piel, Frédéric B, Steinberg, Martin H, Rees, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollution - adverse effects alpha-Thalassemia - genetics Anemia, Sickle Cell - complications Anemia, Sickle Cell - epidemiology Anemia, Sickle Cell - genetics Anemia, Sickle Cell - therapy Deoxyribonucleic acid DNA Environmental factors Estimates Fetal Hemoglobin - physiology Health care access Hemoglobin High income Humans Infant, Newborn Infection - complications Life expectancy Medical screening Mortality Mutation Outdoor air quality Phenotype Quality of life Sickle cell anemia Sickle cell disease Stroke
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