Early life antibiotic use and the risk of asthma and asthma exacerbations in children
Background The use of antibiotic therapy early in life might influence the risk of developing asthma. Studies assessing the influence of early life antibiotic use on the risk of asthma exacerbations are limited, and the results are inconsistent. Therefore, the aim of this study was to assess the ass...
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| Veröffentlicht in: | Pediatric allergy and immunology 2017-08, Vol.28 (5), p.430-437 |
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| creator | Ahmadizar, Fariba Vijverberg, Susanne J. H. Arets, Hubertus G. M. Boer, Anthonius Turner, Steve Devereux, Graham Arabkhazaeli, Ali Soares, Patricia Mukhopadhyay, Somnath Garssen, Johan Palmer, Colin N. A. de Jongste, Johan C. Jaddoe, Vincent W. V. Duijts, Liesbeth Meel, Evelien R. Kraneveld, Aletta D. Maitland‐van der Zee, Anke H. |
| description | Background
The use of antibiotic therapy early in life might influence the risk of developing asthma. Studies assessing the influence of early life antibiotic use on the risk of asthma exacerbations are limited, and the results are inconsistent. Therefore, the aim of this study was to assess the association between use of antibiotic during the first 3 years of life and the risk of developing childhood asthma and the occurrence of asthma exacerbations.
Methods
Data from four large childhood cohorts were used; two population‐based cohorts to study the risk of developing asthma: Generation R (n=7393, The Netherlands) and SEATON (n=891, Scotland, UK), and two asthma cohorts to assess the risk of asthma exacerbations: PACMAN (n=668, The Netherlands) and BREATHE (n=806, Scotland, UK). Odds ratios (ORs) were derived from logistic regression analysis within each database followed by pooling the results using a fixed‐ or random‐effect model.
Results
Antibiotic use in early life was associated with an increased risk of asthma in a meta‐analysis of the Generation R and SEATON data (OR: 2.18, 95% CI: 1.04‐4.60; I2: 76.3%). There was no association between antibiotic use in early life and risk of asthma exacerbations later in life in a meta‐analysis of the PACMAN and BREATHE data (OR: 0.93, 95% CI: 0.65‐1.32; I2: 0.0%).
Conclusion
Children treated with antibiotic in the first 3 years of life are more likely to develop asthma, but there is no evidence that the exposure to antibiotic is associated with increased risk of asthma exacerbations. |
| doi_str_mv | 10.1111/pai.12725 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1891089159</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1891089159</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4545-7cb4bf79e3fce4d1f62b0982e7c3b9093e70b686dd009aaa08ae84caf94a65283</originalsourceid><addsrcrecordid>eNp1kEFLwzAUx4Mobk4PfgEJeNFDt6RJ2uQ4xtSBoAd3Dmn6yjK7diYtum9vt04PgoFH3nv8-PH4I3RNyZh2b7I1bkzjNBYnaEiZUhEjTJ6iIVFERAkV6QBdhLAmhKYsoedoEEseM56kQ7ScG1_ucOkKwKZqXObqxlnchv2Y42YF2LvwjusCm9CsNuawPrbwZSz4zDSurgJ2FbYrV-Yeqkt0VpgywNXxH6Hlw_xt9hQ9vzwuZtPnyHLBRZTajGdFqoAVFnhOiyTOiJIxpJZliigGKckSmeQ5IcoYQ6QBya0pFDeJiCUbobveu_X1Rwuh0RsXLJSlqaBug6ZSUdKVUB16-wdd162vuus0VbEgkhMqOuq-p6yvQ_BQ6K13G-N3mhK9z1p3WetD1h17czS22QbyX_In3A6Y9MCnK2H3v0m_The98hudHIeP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1925084015</pqid></control><display><type>article</type><title>Early life antibiotic use and the risk of asthma and asthma exacerbations in children</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Ahmadizar, Fariba ; Vijverberg, Susanne J. H. ; Arets, Hubertus G. M. ; Boer, Anthonius ; Turner, Steve ; Devereux, Graham ; Arabkhazaeli, Ali ; Soares, Patricia ; Mukhopadhyay, Somnath ; Garssen, Johan ; Palmer, Colin N. A. ; de Jongste, Johan C. ; Jaddoe, Vincent W. V. ; Duijts, Liesbeth ; Meel, Evelien R. ; Kraneveld, Aletta D. ; Maitland‐van der Zee, Anke H.</creator><creatorcontrib>Ahmadizar, Fariba ; Vijverberg, Susanne J. H. ; Arets, Hubertus G. M. ; Boer, Anthonius ; Turner, Steve ; Devereux, Graham ; Arabkhazaeli, Ali ; Soares, Patricia ; Mukhopadhyay, Somnath ; Garssen, Johan ; Palmer, Colin N. A. ; de Jongste, Johan C. ; Jaddoe, Vincent W. V. ; Duijts, Liesbeth ; Meel, Evelien R. ; Kraneveld, Aletta D. ; Maitland‐van der Zee, Anke H.</creatorcontrib><description>Background
The use of antibiotic therapy early in life might influence the risk of developing asthma. Studies assessing the influence of early life antibiotic use on the risk of asthma exacerbations are limited, and the results are inconsistent. Therefore, the aim of this study was to assess the association between use of antibiotic during the first 3 years of life and the risk of developing childhood asthma and the occurrence of asthma exacerbations.
Methods
Data from four large childhood cohorts were used; two population‐based cohorts to study the risk of developing asthma: Generation R (n=7393, The Netherlands) and SEATON (n=891, Scotland, UK), and two asthma cohorts to assess the risk of asthma exacerbations: PACMAN (n=668, The Netherlands) and BREATHE (n=806, Scotland, UK). Odds ratios (ORs) were derived from logistic regression analysis within each database followed by pooling the results using a fixed‐ or random‐effect model.
Results
Antibiotic use in early life was associated with an increased risk of asthma in a meta‐analysis of the Generation R and SEATON data (OR: 2.18, 95% CI: 1.04‐4.60; I2: 76.3%). There was no association between antibiotic use in early life and risk of asthma exacerbations later in life in a meta‐analysis of the PACMAN and BREATHE data (OR: 0.93, 95% CI: 0.65‐1.32; I2: 0.0%).
Conclusion
Children treated with antibiotic in the first 3 years of life are more likely to develop asthma, but there is no evidence that the exposure to antibiotic is associated with increased risk of asthma exacerbations.</description><identifier>ISSN: 0905-6157</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1111/pai.12725</identifier><identifier>PMID: 28423467</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Anti-Bacterial Agents - adverse effects ; antibiotic ; Antibiotics ; Asthma ; Asthma - chemically induced ; asthma exacerbations ; Child ; Child, Preschool ; Children ; Disease Progression ; early life ; Female ; Health risk assessment ; Humans ; Infant ; Infant, Newborn ; Logistic Models ; Male ; Odds Ratio ; pediatrics ; Population studies ; Regression analysis ; Risk assessment ; Risk Factors ; Vehicle emissions ; Young Adult</subject><ispartof>Pediatric allergy and immunology, 2017-08, Vol.28 (5), p.430-437</ispartof><rights>2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4545-7cb4bf79e3fce4d1f62b0982e7c3b9093e70b686dd009aaa08ae84caf94a65283</citedby><cites>FETCH-LOGICAL-c4545-7cb4bf79e3fce4d1f62b0982e7c3b9093e70b686dd009aaa08ae84caf94a65283</cites><orcidid>0000-0002-0826-9931 ; 0000-0001-8393-5060 ; 0000-0001-9601-2118</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpai.12725$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpai.12725$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28423467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmadizar, Fariba</creatorcontrib><creatorcontrib>Vijverberg, Susanne J. H.</creatorcontrib><creatorcontrib>Arets, Hubertus G. M.</creatorcontrib><creatorcontrib>Boer, Anthonius</creatorcontrib><creatorcontrib>Turner, Steve</creatorcontrib><creatorcontrib>Devereux, Graham</creatorcontrib><creatorcontrib>Arabkhazaeli, Ali</creatorcontrib><creatorcontrib>Soares, Patricia</creatorcontrib><creatorcontrib>Mukhopadhyay, Somnath</creatorcontrib><creatorcontrib>Garssen, Johan</creatorcontrib><creatorcontrib>Palmer, Colin N. A.</creatorcontrib><creatorcontrib>de Jongste, Johan C.</creatorcontrib><creatorcontrib>Jaddoe, Vincent W. V.</creatorcontrib><creatorcontrib>Duijts, Liesbeth</creatorcontrib><creatorcontrib>Meel, Evelien R.</creatorcontrib><creatorcontrib>Kraneveld, Aletta D.</creatorcontrib><creatorcontrib>Maitland‐van der Zee, Anke H.</creatorcontrib><title>Early life antibiotic use and the risk of asthma and asthma exacerbations in children</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>Background
The use of antibiotic therapy early in life might influence the risk of developing asthma. Studies assessing the influence of early life antibiotic use on the risk of asthma exacerbations are limited, and the results are inconsistent. Therefore, the aim of this study was to assess the association between use of antibiotic during the first 3 years of life and the risk of developing childhood asthma and the occurrence of asthma exacerbations.
Methods
Data from four large childhood cohorts were used; two population‐based cohorts to study the risk of developing asthma: Generation R (n=7393, The Netherlands) and SEATON (n=891, Scotland, UK), and two asthma cohorts to assess the risk of asthma exacerbations: PACMAN (n=668, The Netherlands) and BREATHE (n=806, Scotland, UK). Odds ratios (ORs) were derived from logistic regression analysis within each database followed by pooling the results using a fixed‐ or random‐effect model.
Results
Antibiotic use in early life was associated with an increased risk of asthma in a meta‐analysis of the Generation R and SEATON data (OR: 2.18, 95% CI: 1.04‐4.60; I2: 76.3%). There was no association between antibiotic use in early life and risk of asthma exacerbations later in life in a meta‐analysis of the PACMAN and BREATHE data (OR: 0.93, 95% CI: 0.65‐1.32; I2: 0.0%).
Conclusion
Children treated with antibiotic in the first 3 years of life are more likely to develop asthma, but there is no evidence that the exposure to antibiotic is associated with increased risk of asthma exacerbations.</description><subject>Adolescent</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>antibiotic</subject><subject>Antibiotics</subject><subject>Asthma</subject><subject>Asthma - chemically induced</subject><subject>asthma exacerbations</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Disease Progression</subject><subject>early life</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Odds Ratio</subject><subject>pediatrics</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Risk assessment</subject><subject>Risk Factors</subject><subject>Vehicle emissions</subject><subject>Young Adult</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFLwzAUx4Mobk4PfgEJeNFDt6RJ2uQ4xtSBoAd3Dmn6yjK7diYtum9vt04PgoFH3nv8-PH4I3RNyZh2b7I1bkzjNBYnaEiZUhEjTJ6iIVFERAkV6QBdhLAmhKYsoedoEEseM56kQ7ScG1_ucOkKwKZqXObqxlnchv2Y42YF2LvwjusCm9CsNuawPrbwZSz4zDSurgJ2FbYrV-Yeqkt0VpgywNXxH6Hlw_xt9hQ9vzwuZtPnyHLBRZTajGdFqoAVFnhOiyTOiJIxpJZliigGKckSmeQ5IcoYQ6QBya0pFDeJiCUbobveu_X1Rwuh0RsXLJSlqaBug6ZSUdKVUB16-wdd162vuus0VbEgkhMqOuq-p6yvQ_BQ6K13G-N3mhK9z1p3WetD1h17czS22QbyX_In3A6Y9MCnK2H3v0m_The98hudHIeP</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Ahmadizar, Fariba</creator><creator>Vijverberg, Susanne J. H.</creator><creator>Arets, Hubertus G. M.</creator><creator>Boer, Anthonius</creator><creator>Turner, Steve</creator><creator>Devereux, Graham</creator><creator>Arabkhazaeli, Ali</creator><creator>Soares, Patricia</creator><creator>Mukhopadhyay, Somnath</creator><creator>Garssen, Johan</creator><creator>Palmer, Colin N. A.</creator><creator>de Jongste, Johan C.</creator><creator>Jaddoe, Vincent W. V.</creator><creator>Duijts, Liesbeth</creator><creator>Meel, Evelien R.</creator><creator>Kraneveld, Aletta D.</creator><creator>Maitland‐van der Zee, Anke H.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0826-9931</orcidid><orcidid>https://orcid.org/0000-0001-8393-5060</orcidid><orcidid>https://orcid.org/0000-0001-9601-2118</orcidid></search><sort><creationdate>201708</creationdate><title>Early life antibiotic use and the risk of asthma and asthma exacerbations in children</title><author>Ahmadizar, Fariba ; Vijverberg, Susanne J. H. ; Arets, Hubertus G. M. ; Boer, Anthonius ; Turner, Steve ; Devereux, Graham ; Arabkhazaeli, Ali ; Soares, Patricia ; Mukhopadhyay, Somnath ; Garssen, Johan ; Palmer, Colin N. A. ; de Jongste, Johan C. ; Jaddoe, Vincent W. 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H.</creatorcontrib><creatorcontrib>Arets, Hubertus G. M.</creatorcontrib><creatorcontrib>Boer, Anthonius</creatorcontrib><creatorcontrib>Turner, Steve</creatorcontrib><creatorcontrib>Devereux, Graham</creatorcontrib><creatorcontrib>Arabkhazaeli, Ali</creatorcontrib><creatorcontrib>Soares, Patricia</creatorcontrib><creatorcontrib>Mukhopadhyay, Somnath</creatorcontrib><creatorcontrib>Garssen, Johan</creatorcontrib><creatorcontrib>Palmer, Colin N. A.</creatorcontrib><creatorcontrib>de Jongste, Johan C.</creatorcontrib><creatorcontrib>Jaddoe, Vincent W. V.</creatorcontrib><creatorcontrib>Duijts, Liesbeth</creatorcontrib><creatorcontrib>Meel, Evelien R.</creatorcontrib><creatorcontrib>Kraneveld, Aletta D.</creatorcontrib><creatorcontrib>Maitland‐van der Zee, Anke H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmadizar, Fariba</au><au>Vijverberg, Susanne J. H.</au><au>Arets, Hubertus G. M.</au><au>Boer, Anthonius</au><au>Turner, Steve</au><au>Devereux, Graham</au><au>Arabkhazaeli, Ali</au><au>Soares, Patricia</au><au>Mukhopadhyay, Somnath</au><au>Garssen, Johan</au><au>Palmer, Colin N. A.</au><au>de Jongste, Johan C.</au><au>Jaddoe, Vincent W. V.</au><au>Duijts, Liesbeth</au><au>Meel, Evelien R.</au><au>Kraneveld, Aletta D.</au><au>Maitland‐van der Zee, Anke H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early life antibiotic use and the risk of asthma and asthma exacerbations in children</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2017-08</date><risdate>2017</risdate><volume>28</volume><issue>5</issue><spage>430</spage><epage>437</epage><pages>430-437</pages><issn>0905-6157</issn><eissn>1399-3038</eissn><abstract>Background
The use of antibiotic therapy early in life might influence the risk of developing asthma. Studies assessing the influence of early life antibiotic use on the risk of asthma exacerbations are limited, and the results are inconsistent. Therefore, the aim of this study was to assess the association between use of antibiotic during the first 3 years of life and the risk of developing childhood asthma and the occurrence of asthma exacerbations.
Methods
Data from four large childhood cohorts were used; two population‐based cohorts to study the risk of developing asthma: Generation R (n=7393, The Netherlands) and SEATON (n=891, Scotland, UK), and two asthma cohorts to assess the risk of asthma exacerbations: PACMAN (n=668, The Netherlands) and BREATHE (n=806, Scotland, UK). Odds ratios (ORs) were derived from logistic regression analysis within each database followed by pooling the results using a fixed‐ or random‐effect model.
Results
Antibiotic use in early life was associated with an increased risk of asthma in a meta‐analysis of the Generation R and SEATON data (OR: 2.18, 95% CI: 1.04‐4.60; I2: 76.3%). There was no association between antibiotic use in early life and risk of asthma exacerbations later in life in a meta‐analysis of the PACMAN and BREATHE data (OR: 0.93, 95% CI: 0.65‐1.32; I2: 0.0%).
Conclusion
Children treated with antibiotic in the first 3 years of life are more likely to develop asthma, but there is no evidence that the exposure to antibiotic is associated with increased risk of asthma exacerbations.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28423467</pmid><doi>10.1111/pai.12725</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0826-9931</orcidid><orcidid>https://orcid.org/0000-0001-8393-5060</orcidid><orcidid>https://orcid.org/0000-0001-9601-2118</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatric allergy and immunology, 2017-08, Vol.28 (5), p.430-437 |
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| subjects | Adolescent Anti-Bacterial Agents - adverse effects antibiotic Antibiotics Asthma Asthma - chemically induced asthma exacerbations Child Child, Preschool Children Disease Progression early life Female Health risk assessment Humans Infant Infant, Newborn Logistic Models Male Odds Ratio pediatrics Population studies Regression analysis Risk assessment Risk Factors Vehicle emissions Young Adult |
| title | Early life antibiotic use and the risk of asthma and asthma exacerbations in children |
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