Cypermethrin induces glutathione S-transferase activity in the shore crab, Carcinus maenas
Cypermethrin is a synthetic pyrethroid that is particularly toxic to crustacea. It is therefore applied as a chemotherapeutant in the salmonid aquaculture industry for the treatment of sea lice infestations. After use, cypermethrin is released directly into the marine environment, to be diluted by f...
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| Veröffentlicht in: | Marine environmental research 2002-08, Vol.54 (2), p.169-177 |
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| creator | Gowland, Ben T.G Moffat, Colin F Stagg, Ron M Houlihan, Dominic F Davies, Ian M |
| description | Cypermethrin is a synthetic pyrethroid that is particularly toxic to crustacea. It is therefore applied as a chemotherapeutant in the salmonid aquaculture industry for the treatment of sea lice infestations. After use, cypermethrin is released directly into the marine environment, to be diluted by fresh seawater. The shore crab,
Carcinus maenas is found in the vicinity of fish farms, and may come into contact with released cypermethrin. The detoxification enzyme, glutathione
S-transferase (GST) has been implicated in cypermethrin metabolism in terrestrial arthropods, but this has not yet been demonstrated in crustacea. In this paper we investigate the response of GST activity in
Carcinus to cypermethrin exposure, and also the time course of the induction process. GST activity is significantly increased in
Carcinus exposed to nominal concentrations of 50 and 500 ng/l of water-borne cypermethrin.
Carcinus demonstrate a significant elevation in GST activity following intra-cephalothoracic injection with 10 ng of cypermethrin. GST activity returns to basal levels after 36 h. The potential application of GST activity in
Carcinus as a biomarker of cypermethrin exposure is discussed. |
| doi_str_mv | 10.1016/S0141-1136(02)00105-8 |
| format | Article |
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Carcinus maenas is found in the vicinity of fish farms, and may come into contact with released cypermethrin. The detoxification enzyme, glutathione
S-transferase (GST) has been implicated in cypermethrin metabolism in terrestrial arthropods, but this has not yet been demonstrated in crustacea. In this paper we investigate the response of GST activity in
Carcinus to cypermethrin exposure, and also the time course of the induction process. GST activity is significantly increased in
Carcinus exposed to nominal concentrations of 50 and 500 ng/l of water-borne cypermethrin.
Carcinus demonstrate a significant elevation in GST activity following intra-cephalothoracic injection with 10 ng of cypermethrin. GST activity returns to basal levels after 36 h. The potential application of GST activity in
Carcinus as a biomarker of cypermethrin exposure is discussed.</description><identifier>ISSN: 0141-1136</identifier><identifier>EISSN: 1879-0291</identifier><identifier>DOI: 10.1016/S0141-1136(02)00105-8</identifier><identifier>PMID: 12206409</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; biomarkers ; Brachyura - drug effects ; Brachyura - enzymology ; Carcinus maenas ; Cypermethrin ; Dose-Response Relationship, Drug ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on protozoa and invertebrates ; Environmental Monitoring - methods ; Fish Diseases - prevention & control ; Fishes ; Fundamental and applied biological sciences. Psychology ; Glutathione S-transferase ; Glutathione Transferase - biosynthesis ; Glutathione Transferase - drug effects ; GST ; Insecticides - administration & dosage ; Insecticides - therapeutic use ; Insecticides - toxicity ; Lice Infestations - prevention & control ; Marine ; Pyrethrins - administration & dosage ; Pyrethrins - therapeutic use ; Pyrethrins - toxicity ; Pyrethroid ; Sea lice ; Time Factors</subject><ispartof>Marine environmental research, 2002-08, Vol.54 (2), p.169-177</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-b755aed01559ee9bdeb8e8a8a17a482f6fce25b109b0da6a4593690934a576ae3</citedby><cites>FETCH-LOGICAL-c486t-b755aed01559ee9bdeb8e8a8a17a482f6fce25b109b0da6a4593690934a576ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0141-1136(02)00105-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13766967$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12206409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gowland, Ben T.G</creatorcontrib><creatorcontrib>Moffat, Colin F</creatorcontrib><creatorcontrib>Stagg, Ron M</creatorcontrib><creatorcontrib>Houlihan, Dominic F</creatorcontrib><creatorcontrib>Davies, Ian M</creatorcontrib><title>Cypermethrin induces glutathione S-transferase activity in the shore crab, Carcinus maenas</title><title>Marine environmental research</title><addtitle>Mar Environ Res</addtitle><description>Cypermethrin is a synthetic pyrethroid that is particularly toxic to crustacea. It is therefore applied as a chemotherapeutant in the salmonid aquaculture industry for the treatment of sea lice infestations. After use, cypermethrin is released directly into the marine environment, to be diluted by fresh seawater. The shore crab,
Carcinus maenas is found in the vicinity of fish farms, and may come into contact with released cypermethrin. The detoxification enzyme, glutathione
S-transferase (GST) has been implicated in cypermethrin metabolism in terrestrial arthropods, but this has not yet been demonstrated in crustacea. In this paper we investigate the response of GST activity in
Carcinus to cypermethrin exposure, and also the time course of the induction process. GST activity is significantly increased in
Carcinus exposed to nominal concentrations of 50 and 500 ng/l of water-borne cypermethrin.
Carcinus demonstrate a significant elevation in GST activity following intra-cephalothoracic injection with 10 ng of cypermethrin. GST activity returns to basal levels after 36 h. The potential application of GST activity in
Carcinus as a biomarker of cypermethrin exposure is discussed.</description><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Brachyura - drug effects</subject><subject>Brachyura - enzymology</subject><subject>Carcinus maenas</subject><subject>Cypermethrin</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on protozoa and invertebrates</subject><subject>Environmental Monitoring - methods</subject><subject>Fish Diseases - prevention & control</subject><subject>Fishes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutathione S-transferase</subject><subject>Glutathione Transferase - biosynthesis</subject><subject>Glutathione Transferase - drug effects</subject><subject>GST</subject><subject>Insecticides - administration & dosage</subject><subject>Insecticides - therapeutic use</subject><subject>Insecticides - toxicity</subject><subject>Lice Infestations - prevention & control</subject><subject>Marine</subject><subject>Pyrethrins - administration & dosage</subject><subject>Pyrethrins - therapeutic use</subject><subject>Pyrethrins - toxicity</subject><subject>Pyrethroid</subject><subject>Sea lice</subject><subject>Time Factors</subject><issn>0141-1136</issn><issn>1879-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U1v1DAQBmALgei28BNAuYCKRGCc2I59QmhVSqVKPRQuXKyJM2GN8rHYTqX993i7K3qjnHx5ZvxqXsZecfjAgauPt8AFLzmv1TlU7wA4yFI_YSuuG1NCZfhTtvpLTthpjL8AQDZcPmcnvKpACTAr9mO921IYKW2Cnwo_dYujWPwcloRp4-eJitsyBZxiTwEjFeiSv_Npl2mRNlTEzRyocAHb98Uag_PTEosRacL4gj3rcYj08viese9fLr6tv5bXN5dX68_XpRNapbJtpETqgEtpiEzbUatJo0beoNBVr3pHlWw5mBY6VCikqZUBUwuUjUKqz9jbw95tmH8vFJMdfXQ0DDjRvETLtQEBqv4PKJUyWmR4_m-olBT5zqLJVB6oC3OMgXq7DX7EsLMc7L4oe1-U3bdgobL3RVmd514fv1jakbqHqWMzGbw5AowOhz534Hx8cHWTs6p9gE8HR_nEd56Cjc7T5KjzgVyy3ewfifIHZrSvXw</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Gowland, Ben T.G</creator><creator>Moffat, Colin F</creator><creator>Stagg, Ron M</creator><creator>Houlihan, Dominic F</creator><creator>Davies, Ian M</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TN</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>C1K</scope><scope>H95</scope><scope>H97</scope><scope>H98</scope></search><sort><creationdate>20020801</creationdate><title>Cypermethrin induces glutathione S-transferase activity in the shore crab, Carcinus maenas</title><author>Gowland, Ben T.G ; Moffat, Colin F ; Stagg, Ron M ; Houlihan, Dominic F ; Davies, Ian M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-b755aed01559ee9bdeb8e8a8a17a482f6fce25b109b0da6a4593690934a576ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Brachyura - drug effects</topic><topic>Brachyura - enzymology</topic><topic>Carcinus maenas</topic><topic>Cypermethrin</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on protozoa and invertebrates</topic><topic>Environmental Monitoring - methods</topic><topic>Fish Diseases - prevention & control</topic><topic>Fishes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutathione S-transferase</topic><topic>Glutathione Transferase - biosynthesis</topic><topic>Glutathione Transferase - drug effects</topic><topic>GST</topic><topic>Insecticides - administration & dosage</topic><topic>Insecticides - therapeutic use</topic><topic>Insecticides - toxicity</topic><topic>Lice Infestations - prevention & control</topic><topic>Marine</topic><topic>Pyrethrins - administration & dosage</topic><topic>Pyrethrins - therapeutic use</topic><topic>Pyrethrins - toxicity</topic><topic>Pyrethroid</topic><topic>Sea lice</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gowland, Ben T.G</creatorcontrib><creatorcontrib>Moffat, Colin F</creatorcontrib><creatorcontrib>Stagg, Ron M</creatorcontrib><creatorcontrib>Houlihan, Dominic F</creatorcontrib><creatorcontrib>Davies, Ian M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oceanic Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><jtitle>Marine environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gowland, Ben T.G</au><au>Moffat, Colin F</au><au>Stagg, Ron M</au><au>Houlihan, Dominic F</au><au>Davies, Ian M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cypermethrin induces glutathione S-transferase activity in the shore crab, Carcinus maenas</atitle><jtitle>Marine environmental research</jtitle><addtitle>Mar Environ Res</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>54</volume><issue>2</issue><spage>169</spage><epage>177</epage><pages>169-177</pages><issn>0141-1136</issn><eissn>1879-0291</eissn><abstract>Cypermethrin is a synthetic pyrethroid that is particularly toxic to crustacea. It is therefore applied as a chemotherapeutant in the salmonid aquaculture industry for the treatment of sea lice infestations. After use, cypermethrin is released directly into the marine environment, to be diluted by fresh seawater. The shore crab,
Carcinus maenas is found in the vicinity of fish farms, and may come into contact with released cypermethrin. The detoxification enzyme, glutathione
S-transferase (GST) has been implicated in cypermethrin metabolism in terrestrial arthropods, but this has not yet been demonstrated in crustacea. In this paper we investigate the response of GST activity in
Carcinus to cypermethrin exposure, and also the time course of the induction process. GST activity is significantly increased in
Carcinus exposed to nominal concentrations of 50 and 500 ng/l of water-borne cypermethrin.
Carcinus demonstrate a significant elevation in GST activity following intra-cephalothoracic injection with 10 ng of cypermethrin. GST activity returns to basal levels after 36 h. The potential application of GST activity in
Carcinus as a biomarker of cypermethrin exposure is discussed.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12206409</pmid><doi>10.1016/S0141-1136(02)00105-8</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0141-1136 |
| ispartof | Marine environmental research, 2002-08, Vol.54 (2), p.169-177 |
| issn | 0141-1136 1879-0291 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18904063 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences biomarkers Brachyura - drug effects Brachyura - enzymology Carcinus maenas Cypermethrin Dose-Response Relationship, Drug Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on protozoa and invertebrates Environmental Monitoring - methods Fish Diseases - prevention & control Fishes Fundamental and applied biological sciences. Psychology Glutathione S-transferase Glutathione Transferase - biosynthesis Glutathione Transferase - drug effects GST Insecticides - administration & dosage Insecticides - therapeutic use Insecticides - toxicity Lice Infestations - prevention & control Marine Pyrethrins - administration & dosage Pyrethrins - therapeutic use Pyrethrins - toxicity Pyrethroid Sea lice Time Factors |
| title | Cypermethrin induces glutathione S-transferase activity in the shore crab, Carcinus maenas |
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