Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity
Microcystins produced by cyanobacteria are potent and specific hepatotoxins; however, the mechanisms of microcystin-induced hepatotoxicity have not been fully elucidated. The induction of free radical formation and mitochondrial alterations are two major events found in microcystin-treated cultured...
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| Veröffentlicht in: | FEMS Microbiology Letters 2003-03, Vol.220 (1), p.1-7 |
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| description | Microcystins produced by cyanobacteria are potent and specific hepatotoxins; however, the mechanisms of microcystin-induced hepatotoxicity have not been fully elucidated. The induction of free radical formation and mitochondrial alterations are two major events found in microcystin-treated cultured rat hepatocytes. The mitochondrial alterations, i.e. loss of mitochondrial membrane potential and mitochondria permeability transition are now recognized as key steps in apoptosis. The activation of calpain and Ca
2+/calmodulin-dependent protein kinase II is believed to be critical in the microcystin-induced apoptotic process. |
| doi_str_mv | 10.1016/S0378-1097(03)00100-9 |
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2+/calmodulin-dependent protein kinase II is believed to be critical in the microcystin-induced apoptotic process.</description><identifier>ISSN: 0378-1097</identifier><identifier>EISSN: 1574-6968</identifier><identifier>DOI: 10.1016/S0378-1097(03)00100-9</identifier><identifier>PMID: 12644220</identifier><identifier>CODEN: FMLED7</identifier><language>eng</language><publisher>Oxford, UK: Elsevier B.V</publisher><subject>Animals ; Apoptosis ; Apoptosis - physiology ; Bacteriology ; Biological and medical sciences ; Calcium Signaling - drug effects ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Calcium-Calmodulin-Dependent Protein Kinases - metabolism ; calpain ; Calpain - metabolism ; Caspases - physiology ; Chemical and Drug Induced Liver Injury - etiology ; Chemical and Drug Induced Liver Injury - microbiology ; Cyanobacteria ; Cyanobacteria - physiology ; Cyanophyta ; Cysteine Proteinase Inhibitors - pharmacology ; Enzyme Activation - drug effects ; Fundamental and applied biological sciences. Psychology ; hepatocytes ; Hepatocytes - drug effects ; Hepatocytes - ultrastructure ; Hepatotoxicity ; hepatotoxins ; Humans ; Intracellular Membranes - drug effects ; Intracellular Membranes - metabolism ; membrane potential ; Microbiology ; Microcystin ; Microcystins ; Miscellaneous ; mitochondria ; Mitochondria, Liver - drug effects ; Mitochondria, Liver - pathology ; mitochondrial membrane ; Models, Biological ; Molecular Structure ; Oxidative Stress ; Peptides, Cyclic - adverse effects ; Peptides, Cyclic - pharmacology ; Permeability ; Rats ; Reactive oxygen species ; Reactive Oxygen Species - metabolism</subject><ispartof>FEMS Microbiology Letters, 2003-03, Vol.220 (1), p.1-7</ispartof><rights>2003 Federation of European Microbiological Societies</rights><rights>2003 Federation of European Microbiological Societies 2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5351-92f7d13c0c57ae73c95ad5176d053f04d7b80eba6abb0726dba0f5908c45a38e3</citedby><cites>FETCH-LOGICAL-c5351-92f7d13c0c57ae73c95ad5176d053f04d7b80eba6abb0726dba0f5908c45a38e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0378-1097%2803%2900100-9$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2FS0378-1097%2803%2900100-9$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>313,314,780,784,792,1417,27922,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14659755$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12644220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, Wen-Xing</creatorcontrib><creatorcontrib>Nam Ong, Choon</creatorcontrib><title>Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity</title><title>FEMS Microbiology Letters</title><addtitle>FEMS Microbiol Lett</addtitle><description>Microcystins produced by cyanobacteria are potent and specific hepatotoxins; however, the mechanisms of microcystin-induced hepatotoxicity have not been fully elucidated. The induction of free radical formation and mitochondrial alterations are two major events found in microcystin-treated cultured rat hepatocytes. The mitochondrial alterations, i.e. loss of mitochondrial membrane potential and mitochondria permeability transition are now recognized as key steps in apoptosis. The activation of calpain and Ca
2+/calmodulin-dependent protein kinase II is believed to be critical in the microcystin-induced apoptotic process.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Calcium Signaling - drug effects</subject><subject>Calcium-Calmodulin-Dependent Protein Kinase Type 2</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases - metabolism</subject><subject>calpain</subject><subject>Calpain - metabolism</subject><subject>Caspases - physiology</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Chemical and Drug Induced Liver Injury - microbiology</subject><subject>Cyanobacteria</subject><subject>Cyanobacteria - physiology</subject><subject>Cyanophyta</subject><subject>Cysteine Proteinase Inhibitors - pharmacology</subject><subject>Enzyme Activation - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hepatocytes</subject><subject>Hepatocytes - drug effects</subject><subject>Hepatocytes - ultrastructure</subject><subject>Hepatotoxicity</subject><subject>hepatotoxins</subject><subject>Humans</subject><subject>Intracellular Membranes - drug effects</subject><subject>Intracellular Membranes - metabolism</subject><subject>membrane potential</subject><subject>Microbiology</subject><subject>Microcystin</subject><subject>Microcystins</subject><subject>Miscellaneous</subject><subject>mitochondria</subject><subject>Mitochondria, Liver - drug effects</subject><subject>Mitochondria, Liver - pathology</subject><subject>mitochondrial membrane</subject><subject>Models, Biological</subject><subject>Molecular Structure</subject><subject>Oxidative Stress</subject><subject>Peptides, Cyclic - adverse effects</subject><subject>Peptides, Cyclic - pharmacology</subject><subject>Permeability</subject><subject>Rats</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><issn>0378-1097</issn><issn>1574-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhi0EokvhEYBcQHAIjOM4Tk4IVRSQFiFRerYm9qRrlI2D7S3s2-NtVlRISHDywd83M_pnGHvM4RUH3ry-AKHakkOnXoB4CcAByu4OW3Gp6rLpmvYuW_1GTtiDGL8BQF1Bc5-d8Kqp66qCFdt88SMVfij8T2cxuWsqYgoUY4GTLbYuebPxkw0Ox8JscLqiWLipMHucfI8mUf4p3WR3hmyBs5-Tj26RNzRj8ikXNi7tH7J7A46RHh3fU3Z5_u7r2Ydy_fn9x7O369JIIXnZVYOyXBgwUiEpYTqJVnLVWJBigNqqvgXqscG-B1U1tkcYZAetqSWKlsQpe77UnYP_vqOY9NZFQ-OIE_ld1LztQLS8yqBcQBN8jIEGPQe3xbDXHPQhYn0TsT7kp0Hom4h1l70nxwa7fkv21jpmmoFnRwCjwXEIOBkXb7m6kZ2SMnNq4X64kfb_112ff1rzbMJi-t38d6_8wysPUz9dlAG9xquQB7q8qDKfj6JrOW8z8WYhKG_n2lHQ0Tia8l5dIJO09e4fyfwCgyTBDQ</recordid><startdate>20030314</startdate><enddate>20030314</enddate><creator>Ding, Wen-Xing</creator><creator>Nam Ong, Choon</creator><general>Elsevier B.V</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>M7N</scope></search><sort><creationdate>20030314</creationdate><title>Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity</title><author>Ding, Wen-Xing ; Nam Ong, Choon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5351-92f7d13c0c57ae73c95ad5176d053f04d7b80eba6abb0726dba0f5908c45a38e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - physiology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Calcium Signaling - drug effects</topic><topic>Calcium-Calmodulin-Dependent Protein Kinase Type 2</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases - metabolism</topic><topic>calpain</topic><topic>Calpain - metabolism</topic><topic>Caspases - physiology</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Chemical and Drug Induced Liver Injury - microbiology</topic><topic>Cyanobacteria</topic><topic>Cyanobacteria - physiology</topic><topic>Cyanophyta</topic><topic>Cysteine Proteinase Inhibitors - pharmacology</topic><topic>Enzyme Activation - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hepatocytes</topic><topic>Hepatocytes - drug effects</topic><topic>Hepatocytes - ultrastructure</topic><topic>Hepatotoxicity</topic><topic>hepatotoxins</topic><topic>Humans</topic><topic>Intracellular Membranes - drug effects</topic><topic>Intracellular Membranes - metabolism</topic><topic>membrane potential</topic><topic>Microbiology</topic><topic>Microcystin</topic><topic>Microcystins</topic><topic>Miscellaneous</topic><topic>mitochondria</topic><topic>Mitochondria, Liver - drug effects</topic><topic>Mitochondria, Liver - pathology</topic><topic>mitochondrial membrane</topic><topic>Models, Biological</topic><topic>Molecular Structure</topic><topic>Oxidative Stress</topic><topic>Peptides, Cyclic - adverse effects</topic><topic>Peptides, Cyclic - pharmacology</topic><topic>Permeability</topic><topic>Rats</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Wen-Xing</creatorcontrib><creatorcontrib>Nam Ong, Choon</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>FEMS Microbiology Letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Wen-Xing</au><au>Nam Ong, Choon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity</atitle><jtitle>FEMS Microbiology Letters</jtitle><addtitle>FEMS Microbiol Lett</addtitle><date>2003-03-14</date><risdate>2003</risdate><volume>220</volume><issue>1</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0378-1097</issn><eissn>1574-6968</eissn><coden>FMLED7</coden><abstract>Microcystins produced by cyanobacteria are potent and specific hepatotoxins; however, the mechanisms of microcystin-induced hepatotoxicity have not been fully elucidated. The induction of free radical formation and mitochondrial alterations are two major events found in microcystin-treated cultured rat hepatocytes. The mitochondrial alterations, i.e. loss of mitochondrial membrane potential and mitochondria permeability transition are now recognized as key steps in apoptosis. The activation of calpain and Ca
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| subjects | Animals Apoptosis Apoptosis - physiology Bacteriology Biological and medical sciences Calcium Signaling - drug effects Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - metabolism calpain Calpain - metabolism Caspases - physiology Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - microbiology Cyanobacteria Cyanobacteria - physiology Cyanophyta Cysteine Proteinase Inhibitors - pharmacology Enzyme Activation - drug effects Fundamental and applied biological sciences. Psychology hepatocytes Hepatocytes - drug effects Hepatocytes - ultrastructure Hepatotoxicity hepatotoxins Humans Intracellular Membranes - drug effects Intracellular Membranes - metabolism membrane potential Microbiology Microcystin Microcystins Miscellaneous mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - pathology mitochondrial membrane Models, Biological Molecular Structure Oxidative Stress Peptides, Cyclic - adverse effects Peptides, Cyclic - pharmacology Permeability Rats Reactive oxygen species Reactive Oxygen Species - metabolism |
| title | Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity |
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