Comparative analysis between RQ‐PCR and digital droplet PCR of BCL2/IGH gene rearrangement in the peripheral blood and bone marrow of early stage follicular lymphoma

Summary BCL2/IGH rearrangements were analysed by polymerase chain reaction (PCR) at diagnosis in paired peripheral blood (PB) and bone marrow (BM) samples from 67 patients with stage I/II follicular lymphoma (FL). Real time quantitative PCR (RQ‐PCR) and digital droplet PCR (ddPCR) were performed in...

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Veröffentlicht in:	British journal of haematology 2017-05, Vol.177 (4), p.588-596
Hauptverfasser:	Cavalli, Marzia, De Novi, Lucia Anna, Della Starza, Irene, Cappelli, Luca Vincenzo, Nunes, Vittorio, Pulsoni, Alessandro, Del Giudice, Ilaria, Guarini, Anna, Foà, Robin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Bone marrow Bone Marrow - physiology Combined Modality Therapy Comparative analysis ddPCR early stage follicular lymphoma Gene rearrangement Gene Rearrangement, B-Lymphocyte, Heavy Chain - genetics Genes, bcl-2 - genetics Genes, Immunoglobulin Heavy Chain - genetics Heavy chains Hematology Humans Immunoglobulins Leukocytes, Mononuclear - physiology Lymphoma Lymphoma, Follicular - diagnosis Lymphoma, Follicular - genetics Lymphoma, Follicular - therapy Minimal residual disease Monoclonal antibodies Neoplasm, Residual - genetics Peripheral blood Polymerase chain reaction quantitative PCR Radiation therapy Real-Time Polymerase Chain Reaction - methods Rituximab Rituximab - therapeutic use Targeted cancer therapy Translocation, Genetic Tumors
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