Impact of antiretroviral treatment containing tenofovir difumarate on the telomere length of aviremic HIV-infected patients

OBJECTIVE:To evaluate the in vivo relevance of the inhibitory effect of tenofovir upon telomerase activity observed in vitro. DESIGN:Cross sectional study of HIV-infected patients with suppressed virological replication (HIV RNA < 50 copies/mL for more than one year) MethodsTelomere length in who...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2017-09, Vol.76 (1), p.102-109
Hauptverfasser:	Montejano, Rocio, Stella-Ascariz, Natalia, Monge, Susana, Bernardino, José I, Pérez-Valero, Ignacio, Montes, MaLuisa, Valencia, Eulalia, Martín-Carbonero, Luz, Moreno, Victoria, González-García, Juan, Arnalich, Francisco, Mingorance, Jesús, Berniches, Laura Pintado, Perona, Rosario, Arribas, José R
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging - drug effects AIDS/HIV Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Birth Cross-Sectional Studies Exposure Female HIV HIV Infections - drug therapy HIV Infections - pathology HIV Infections - virology HIV-1 - physiology Human immunodeficiency virus Humans Impact analysis In vitro methods and tests Infections Male Middle Aged Molecules Multivariate analysis Nucleoside reverse transcriptase inhibitors Patients Peripheral blood Polymerase chain reaction Race Ribonucleic acid RNA RNA-directed DNA polymerase Spain - epidemiology Telomerase Telomerase - antagonists & inhibitors Telomere - drug effects Tenofovir Tenofovir - pharmacology Tenofovir - therapeutic use Treatment Outcome Viral Load
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