Chronic Toxicology Studies of Basal Insulin Peglispro in Rats and Dogs: A Novel, PEGylated Insulin Lispro Analog with a Prolonged Duration of Action

Basal insulin peglispro (BIL) consists of insulin lispro with a 20-kDa polyethylene glycol (PEG) moiety covalently attached to lysine B28. Because chronic parenteral administration of PEGylated proteins to animals has sometimes resulted in PEG vacuolation of tissue macrophages, renal tubular cells,...

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Veröffentlicht in:	Toxicologic pathology 2017-04, Vol.45 (3), p.402-415
Hauptverfasser:	Byrd, Richard A., Blackbourne, Jamie L., Knadler, Mary Pat, Schultze, Albert E., Vahle, John L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight - drug effects Delayed-Action Preparations Dogs Dose-Response Relationship, Drug Eating - drug effects Ependyma - drug effects Ependyma - pathology Female Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacokinetics Hypoglycemic Agents - toxicity Injections, Subcutaneous Insulin Lispro - administration & dosage Insulin Lispro - analogs & derivatives Insulin Lispro - pharmacokinetics Insulin Lispro - toxicity Kidney Tubules - drug effects Kidney Tubules - pathology Macrophages - drug effects Macrophages - pathology Male Organ Specificity Polyethylene Glycols - administration & dosage Polyethylene Glycols - pharmacokinetics Polyethylene Glycols - toxicity Rats, Sprague-Dawley Species Specificity Survival Analysis Toxicity Tests, Chronic Toxicokinetics
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