MYB–GATA1 fusion promotes basophilic leukaemia: involvement of interleukin‐33 and nerve growth factor receptors

Acute basophilic leukaemia (ABL) is a rare subtype of acute myeloblastic leukaemia. We previously described a recurrent t(X;6)(p11;q23) translocation generating an MYB–GATA1 fusion gene in male infants with ABL. To better understand its role, the chimeric MYB–GATA1 transcription factor was expressed...

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Veröffentlicht in:	The Journal of pathology 2017-07, Vol.242 (3), p.347-357
Hauptverfasser:	Ducassou, Stéphane, Prouzet‐Mauléon, Valérie, Deau, Marie‐Céline, Brunet de la Grange, Philippe, Cardinaud, Bruno, Soueidan, Hayssam, Quelen, Cathy, Brousset, Pierre, Pasquet, Jean‐Max, Moreau‐Gaudry, François, Arock, Michel, Mahon, François‐Xavier, Lippert, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Assaying basophils CD34 antigen Cell Transformation, Neoplastic - genetics Cytokines Female Fusion protein GATA-1 protein GATA1 Transcription Factor - genetics Gene Fusion - physiology Growth factor receptors Growth factors Hematopoietic Stem Cells - physiology IL1RL1 Immunodeficiency Infants Interleukin 1 Interleukin 1 receptors Interleukin-33 - physiology leukaemia Leukemia Leukemia, Basophilic, Acute - etiology Ligands Male Mice Mice, SCID MYB–GATA1 Neoplasm Transplantation Nerve growth factor Nerve growth factor receptors NTRK1 Oncogene Proteins v-myb - genetics Polymerase chain reaction Protein-tyrosine kinase receptors Receptor, trkA - metabolism Receptors, Nerve Growth Factor - physiology Reverse transcription Rodents Stem cells Transcription Factors - metabolism Transfection Translocation Transplantation, Heterologous
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