Effects of riboflavin and ultraviolet light treatment on platelet thrombus formation and thrombus stability on collagen

BACKGROUND Pathogen reduction technologies (PRTs) are considered for the implementation of safer platelet (PLT) transfusion. PRT treatment involves the addition of a photosensitizer to a blood component followed by ultraviolet (UV) light irradiation. However, the effects of PRT treatment on PLT thro...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2017-07, Vol.57 (7), p.1772-1780
Hauptverfasser:	Terada, Chikahiro, Shiba, Masayuki, Nagai, Tadashi, Satake, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Blood clots Blood flow Blood Platelets - drug effects Blood Platelets - radiation effects Buffers Catheters Collagen Collagen - chemistry Contact stresses Flow stability Flushing Humans Inhibitors Irradiation Light irradiation Mechanical stimuli Pathogens Phosphate Phosphates Platelet Glycoprotein GPIIb-IIIa Complex - chemistry Platelets Riboflavin Riboflavin - pharmacology Shear Stress concentration Thrombosis Thrombosis - etiology Transfusion Ultraviolet radiation Ultraviolet Rays Vitamin B
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