Multifunctional nanoparticles self-assembled from polyethylenimine-based graft polymers as efficient anticancer drug delivery
[Display omitted] •Imine-bond was introduced in PEI grafted polymer to construct pH-sensitive drug delivery.•The nanoparticles were coated with hyaluronic acid (HA) for tumor active targeting.•The effect of HA coated drug-loaded nanoparticles was studied in vitro.•HA-coated NPs exhibited better anti...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2017-07, Vol.155, p.118-127 |
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| creator | Yan, Jianqin Su, Ting Cheng, Furong Cao, Jun Zhang, Hai He, Bin |
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•Imine-bond was introduced in PEI grafted polymer to construct pH-sensitive drug delivery.•The nanoparticles were coated with hyaluronic acid (HA) for tumor active targeting.•The effect of HA coated drug-loaded nanoparticles was studied in vitro.•HA-coated NPs exhibited better anticancer efficacy compared to un-coated NPs.
Multiple functionalization of nanoparticles has attracted great interest in drug delivery. In this paper, polymeric amphiphiles of polyethylenimine (PEI) conjugated with methoxy poly(ethylene glycol) aldehyde (mPEG-CHO), poly(ε caprolactone) aldehyde (PCL-CHO) and pyrene-1-carboxaldehyde (Py-CHO) were synthesized via Schiff’s reaction. The conjugates self-assembled into nanoparticles with pH-sensitivity to load anticancer drug doxorubicin (DOX), further coated with hyaluronic acid (HA) for tumor targeting. The mean size of nanoparticles was about 100nm and the stability of the nanoparticles was well in aqueous solution. The nanoparticles coated with HA showed faster disassembly in acidic solution, resulting in faster drug release in the medium with pH 5.0 compared to uncoated nanoparticles. Moreover, the nanoparticles exhibited an endosomal escape function to accelerate the release of DOX in cancer cells, which led to low IC50s to kill breast cancer cells (4T1) and liver cancer cells (HepG2) in vitro. |
| doi_str_mv | 10.1016/j.colsurfb.2017.02.030 |
| format | Article |
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•Imine-bond was introduced in PEI grafted polymer to construct pH-sensitive drug delivery.•The nanoparticles were coated with hyaluronic acid (HA) for tumor active targeting.•The effect of HA coated drug-loaded nanoparticles was studied in vitro.•HA-coated NPs exhibited better anticancer efficacy compared to un-coated NPs.
Multiple functionalization of nanoparticles has attracted great interest in drug delivery. In this paper, polymeric amphiphiles of polyethylenimine (PEI) conjugated with methoxy poly(ethylene glycol) aldehyde (mPEG-CHO), poly(ε caprolactone) aldehyde (PCL-CHO) and pyrene-1-carboxaldehyde (Py-CHO) were synthesized via Schiff’s reaction. The conjugates self-assembled into nanoparticles with pH-sensitivity to load anticancer drug doxorubicin (DOX), further coated with hyaluronic acid (HA) for tumor targeting. The mean size of nanoparticles was about 100nm and the stability of the nanoparticles was well in aqueous solution. The nanoparticles coated with HA showed faster disassembly in acidic solution, resulting in faster drug release in the medium with pH 5.0 compared to uncoated nanoparticles. Moreover, the nanoparticles exhibited an endosomal escape function to accelerate the release of DOX in cancer cells, which led to low IC50s to kill breast cancer cells (4T1) and liver cancer cells (HepG2) in vitro.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2017.02.030</identifier><identifier>PMID: 28415029</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Active target ; Antineoplastic Agents - metabolism ; Antineoplastic Agents - pharmacology ; Biological Transport ; Cell Line, Tumor ; Cell Survival - drug effects ; Doxorubicin - metabolism ; Doxorubicin - pharmacology ; Drug Carriers ; Drug delivery ; Drug Liberation ; Hep G2 Cells ; Humans ; Hyaluronic acid ; Hyaluronic Acid - chemistry ; Hydrogen-Ion Concentration ; Kinetics ; Micelles ; Nanoparticles - chemistry ; Nanoparticles - ultrastructure ; Particle Size ; pH-Sensitive ; Polyesters - chemistry ; Polyethylene Glycols - chemistry ; Polyethyleneimine ; Polyethyleneimine - chemistry</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2017-07, Vol.155, p.118-127</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-544225f0366f037676d0093c91a57cf33f10f4b4292461c5794369e0176c86523</citedby><cites>FETCH-LOGICAL-c405t-544225f0366f037676d0093c91a57cf33f10f4b4292461c5794369e0176c86523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfb.2017.02.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28415029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Jianqin</creatorcontrib><creatorcontrib>Su, Ting</creatorcontrib><creatorcontrib>Cheng, Furong</creatorcontrib><creatorcontrib>Cao, Jun</creatorcontrib><creatorcontrib>Zhang, Hai</creatorcontrib><creatorcontrib>He, Bin</creatorcontrib><title>Multifunctional nanoparticles self-assembled from polyethylenimine-based graft polymers as efficient anticancer drug delivery</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>[Display omitted]
•Imine-bond was introduced in PEI grafted polymer to construct pH-sensitive drug delivery.•The nanoparticles were coated with hyaluronic acid (HA) for tumor active targeting.•The effect of HA coated drug-loaded nanoparticles was studied in vitro.•HA-coated NPs exhibited better anticancer efficacy compared to un-coated NPs.
Multiple functionalization of nanoparticles has attracted great interest in drug delivery. In this paper, polymeric amphiphiles of polyethylenimine (PEI) conjugated with methoxy poly(ethylene glycol) aldehyde (mPEG-CHO), poly(ε caprolactone) aldehyde (PCL-CHO) and pyrene-1-carboxaldehyde (Py-CHO) were synthesized via Schiff’s reaction. The conjugates self-assembled into nanoparticles with pH-sensitivity to load anticancer drug doxorubicin (DOX), further coated with hyaluronic acid (HA) for tumor targeting. The mean size of nanoparticles was about 100nm and the stability of the nanoparticles was well in aqueous solution. The nanoparticles coated with HA showed faster disassembly in acidic solution, resulting in faster drug release in the medium with pH 5.0 compared to uncoated nanoparticles. Moreover, the nanoparticles exhibited an endosomal escape function to accelerate the release of DOX in cancer cells, which led to low IC50s to kill breast cancer cells (4T1) and liver cancer cells (HepG2) in vitro.</description><subject>Active target</subject><subject>Antineoplastic Agents - metabolism</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological Transport</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Doxorubicin - metabolism</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Carriers</subject><subject>Drug delivery</subject><subject>Drug Liberation</subject><subject>Hep G2 Cells</subject><subject>Humans</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Kinetics</subject><subject>Micelles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>Particle Size</subject><subject>pH-Sensitive</subject><subject>Polyesters - chemistry</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethyleneimine</subject><subject>Polyethyleneimine - chemistry</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EotvCX6h85JIwdmI7uYEqCkhFXOBsOc64eOXYi51U2gP_HS_bcu1l5jDvh-Yh5JpBy4DJ9_vWplC27KaWA1Mt8BY6eEF2bFBd03dSvSQ7GLlqlJLiglyWsgcA3jP1mlzwoWcC-Lgjf75tYfVui3b1KZpAo4npYPLqbcBCCwbXmFJwmQLO1OW00EMKR1x_HQNGv_iIzWRKvd1n49Z_xwVzoaZQdM5bj3GlJtY8Ey1mOuftns4Y_APm4xvyyplQ8O3jviI_bz_9uPnS3H3__PXm411jexBrI_qec-Ggk7IOJZWcAcbOjswIZV3XOQaun3o-8l4yK9RYAYxYuUg7SMG7K_LunHvI6feGZdWLLxZDMBHTVjQbhrEbBMihSuVZanMqJaPTh-wXk4-agT6h13v9hF6f0GvguqKvxuvHjm1acP5ve2JdBR_OAqyfPnjMupzoWJx9RrvqOfnnOv4Czymakw</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Yan, Jianqin</creator><creator>Su, Ting</creator><creator>Cheng, Furong</creator><creator>Cao, Jun</creator><creator>Zhang, Hai</creator><creator>He, Bin</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170701</creationdate><title>Multifunctional nanoparticles self-assembled from polyethylenimine-based graft polymers as efficient anticancer drug delivery</title><author>Yan, Jianqin ; Su, Ting ; Cheng, Furong ; Cao, Jun ; Zhang, Hai ; He, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-544225f0366f037676d0093c91a57cf33f10f4b4292461c5794369e0176c86523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Active target</topic><topic>Antineoplastic Agents - metabolism</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological Transport</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Doxorubicin - metabolism</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Carriers</topic><topic>Drug delivery</topic><topic>Drug Liberation</topic><topic>Hep G2 Cells</topic><topic>Humans</topic><topic>Hyaluronic acid</topic><topic>Hyaluronic Acid - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>Kinetics</topic><topic>Micelles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - ultrastructure</topic><topic>Particle Size</topic><topic>pH-Sensitive</topic><topic>Polyesters - chemistry</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethyleneimine</topic><topic>Polyethyleneimine - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Jianqin</creatorcontrib><creatorcontrib>Su, Ting</creatorcontrib><creatorcontrib>Cheng, Furong</creatorcontrib><creatorcontrib>Cao, Jun</creatorcontrib><creatorcontrib>Zhang, Hai</creatorcontrib><creatorcontrib>He, Bin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Jianqin</au><au>Su, Ting</au><au>Cheng, Furong</au><au>Cao, Jun</au><au>Zhang, Hai</au><au>He, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multifunctional nanoparticles self-assembled from polyethylenimine-based graft polymers as efficient anticancer drug delivery</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>155</volume><spage>118</spage><epage>127</epage><pages>118-127</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>[Display omitted]
•Imine-bond was introduced in PEI grafted polymer to construct pH-sensitive drug delivery.•The nanoparticles were coated with hyaluronic acid (HA) for tumor active targeting.•The effect of HA coated drug-loaded nanoparticles was studied in vitro.•HA-coated NPs exhibited better anticancer efficacy compared to un-coated NPs.
Multiple functionalization of nanoparticles has attracted great interest in drug delivery. In this paper, polymeric amphiphiles of polyethylenimine (PEI) conjugated with methoxy poly(ethylene glycol) aldehyde (mPEG-CHO), poly(ε caprolactone) aldehyde (PCL-CHO) and pyrene-1-carboxaldehyde (Py-CHO) were synthesized via Schiff’s reaction. The conjugates self-assembled into nanoparticles with pH-sensitivity to load anticancer drug doxorubicin (DOX), further coated with hyaluronic acid (HA) for tumor targeting. The mean size of nanoparticles was about 100nm and the stability of the nanoparticles was well in aqueous solution. The nanoparticles coated with HA showed faster disassembly in acidic solution, resulting in faster drug release in the medium with pH 5.0 compared to uncoated nanoparticles. Moreover, the nanoparticles exhibited an endosomal escape function to accelerate the release of DOX in cancer cells, which led to low IC50s to kill breast cancer cells (4T1) and liver cancer cells (HepG2) in vitro.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28415029</pmid><doi>10.1016/j.colsurfb.2017.02.030</doi><tpages>10</tpages></addata></record> |
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| subjects | Active target Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Biological Transport Cell Line, Tumor Cell Survival - drug effects Doxorubicin - metabolism Doxorubicin - pharmacology Drug Carriers Drug delivery Drug Liberation Hep G2 Cells Humans Hyaluronic acid Hyaluronic Acid - chemistry Hydrogen-Ion Concentration Kinetics Micelles Nanoparticles - chemistry Nanoparticles - ultrastructure Particle Size pH-Sensitive Polyesters - chemistry Polyethylene Glycols - chemistry Polyethyleneimine Polyethyleneimine - chemistry |
| title | Multifunctional nanoparticles self-assembled from polyethylenimine-based graft polymers as efficient anticancer drug delivery |
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