CYP3A4 is a crosslink between vitamin D and calcineurin inhibitors in solid organ transplant recipients: implications for bone health

The use of calcineurin inhibitors (CNIs) and vitamin D deficiency may contribute to the pathogenesis of post-transplant bone disease. CNIs and 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) are substrates of the drug-metabolizing enzyme CYP3A4 . This review summarizes the indications for the use of act...

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Veröffentlicht in:	The pharmacogenomics journal 2017-12, Vol.17 (6), p.481-487
Hauptverfasser:	Prytuła, A, Cransberg, K, Raes, A
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/575 692/700/459 Animals Biomedical and Life Sciences Biomedicine Bone Density Bone diseases Calcineurin Calcineurin inhibitors Calcineurin Inhibitors - administration & dosage Calcineurin Inhibitors - metabolism Calcitriol Cytochrome P-450 Cytochrome P-450 CYP3A - metabolism Drug Interactions Drug metabolism Enzyme inhibitors Enzymes Gene Expression Genetic aspects Health aspects Health risk assessment Human Genetics Humans Inhibitors Metabolism Oncology Organ Transplantation Osteoporosis - metabolism Pharmacotherapy Psychopharmacology review Substrates Vitamin D Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D - metabolism Vitamin D3 Vitamin deficiency
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