Cu/Pd Synergistic Dual Catalysis: Asymmetric α‐Allylation of an α‐CF3 Amide

Despite the burgeoning demand for fluorine‐containing chemical entities, the construction of CF3‐containing stereogenic centers has remained elusive. Herein, we report the strategic merger of CuI/base‐catalyzed enolization of an α‐CF3 amide and Pd0‐catalyzed allylic alkylation in an enantioselective...

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Veröffentlicht in:	Angewandte Chemie International Edition 2017-05, Vol.56 (20), p.5551-5555
Hauptverfasser:	Saito, Akira, Kumagai, Naoya, Shibasaki, Masakatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	allylic substitution asymmetric catalysis azaindolines dual catalysis organofluorine compounds
Online-Zugang:	Volltext
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