Plutonium content of human placental tissues after occupational exposure
The placenta and umbilical cord were obtained following a normal live delivery from a volunteer donor who had received an accidental inhalation intake of plutonium 12 years prior to her pregnancy (Case 0777). Her employer estimated the intake to be about 73 Bq Class W plutonium. Based on bioassay re...
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| Veröffentlicht in: | Radiation protection dosimetry 2003-01, Vol.104 (3), p.231-236 |
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| creator | RUSSELL, J. J SIKOV, M. R KATHREN, R. L |
| description | The placenta and umbilical cord were obtained following a normal live delivery from a volunteer donor who had received an accidental inhalation intake of plutonium 12 years prior to her pregnancy (Case 0777). Her employer estimated the intake to be about 73 Bq Class W plutonium. Based on bioassay results and clearance models in use at that time, they calculated her body content at the beginning of pregnancy to be about 5.6 Bq with an average concentration of approximately 60 mBq kg-1. The placenta and cord from this pregnancy, along with the placenta and cord from a donor with no known exposure to plutonium (Case 0835), were divided and assayed for plutonium by ultrasensitive fission track analysis at two collaborating laboratories. Placental 239Pu concentration values obtained by the two laboratories for Case 0777 agreed within a factor of 2 and were several-fold greater than for the control, Case 0835, as well as values that had been reported by others for unexposed populations. There was no elevated concentration of plutonium in the umbilical cord from the exposed person. The data yielded values of 0.16 and 0.27 for placental to maternal concentrations (CPI:CM) that were of the same order of magnitude as the value of 0.1 the ICRP calculated for intakes before pregnancy. |
| doi_str_mv | 10.1093/oxfordjournals.rpd.a006186 |
| format | Article |
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J ; SIKOV, M. R ; KATHREN, R. L</creator><creatorcontrib>RUSSELL, J. J ; SIKOV, M. R ; KATHREN, R. L</creatorcontrib><description>The placenta and umbilical cord were obtained following a normal live delivery from a volunteer donor who had received an accidental inhalation intake of plutonium 12 years prior to her pregnancy (Case 0777). Her employer estimated the intake to be about 73 Bq Class W plutonium. Based on bioassay results and clearance models in use at that time, they calculated her body content at the beginning of pregnancy to be about 5.6 Bq with an average concentration of approximately 60 mBq kg-1. The placenta and cord from this pregnancy, along with the placenta and cord from a donor with no known exposure to plutonium (Case 0835), were divided and assayed for plutonium by ultrasensitive fission track analysis at two collaborating laboratories. Placental 239Pu concentration values obtained by the two laboratories for Case 0777 agreed within a factor of 2 and were several-fold greater than for the control, Case 0835, as well as values that had been reported by others for unexposed populations. There was no elevated concentration of plutonium in the umbilical cord from the exposed person. The data yielded values of 0.16 and 0.27 for placental to maternal concentrations (CPI:CM) that were of the same order of magnitude as the value of 0.1 the ICRP calculated for intakes before pregnancy.</description><identifier>ISSN: 0144-8420</identifier><identifier>EISSN: 1742-3406</identifier><identifier>DOI: 10.1093/oxfordjournals.rpd.a006186</identifier><identifier>PMID: 14565729</identifier><identifier>CODEN: RPDODE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; Body Burden ; Computer Simulation ; Female ; Humans ; Maternal Exposure ; Maternal-Fetal Exchange ; Medical sciences ; Models, Biological ; Nuclear Reactors ; Occupational Exposure - analysis ; Placenta - metabolism ; Plutonium - analysis ; Plutonium - pharmacokinetics ; Pregnancy ; Radiation Dosage ; Radioactive Hazard Release ; Radiometry - methods ; Reference Values ; Relative Biological Effectiveness ; Risk Assessment - methods</subject><ispartof>Radiation protection dosimetry, 2003-01, Vol.104 (3), p.231-236</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-7f81c98a3a04236d94764106fe5cea0cde65a8ec19b60d63c076733ee76dabfd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15124827$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14565729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RUSSELL, J. J</creatorcontrib><creatorcontrib>SIKOV, M. R</creatorcontrib><creatorcontrib>KATHREN, R. L</creatorcontrib><title>Plutonium content of human placental tissues after occupational exposure</title><title>Radiation protection dosimetry</title><addtitle>Radiat Prot Dosimetry</addtitle><description>The placenta and umbilical cord were obtained following a normal live delivery from a volunteer donor who had received an accidental inhalation intake of plutonium 12 years prior to her pregnancy (Case 0777). Her employer estimated the intake to be about 73 Bq Class W plutonium. Based on bioassay results and clearance models in use at that time, they calculated her body content at the beginning of pregnancy to be about 5.6 Bq with an average concentration of approximately 60 mBq kg-1. The placenta and cord from this pregnancy, along with the placenta and cord from a donor with no known exposure to plutonium (Case 0835), were divided and assayed for plutonium by ultrasensitive fission track analysis at two collaborating laboratories. Placental 239Pu concentration values obtained by the two laboratories for Case 0777 agreed within a factor of 2 and were several-fold greater than for the control, Case 0835, as well as values that had been reported by others for unexposed populations. There was no elevated concentration of plutonium in the umbilical cord from the exposed person. The data yielded values of 0.16 and 0.27 for placental to maternal concentrations (CPI:CM) that were of the same order of magnitude as the value of 0.1 the ICRP calculated for intakes before pregnancy.</description><subject>Biological and medical sciences</subject><subject>Body Burden</subject><subject>Computer Simulation</subject><subject>Female</subject><subject>Humans</subject><subject>Maternal Exposure</subject><subject>Maternal-Fetal Exchange</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Nuclear Reactors</subject><subject>Occupational Exposure - analysis</subject><subject>Placenta - metabolism</subject><subject>Plutonium - analysis</subject><subject>Plutonium - pharmacokinetics</subject><subject>Pregnancy</subject><subject>Radiation Dosage</subject><subject>Radioactive Hazard Release</subject><subject>Radiometry - methods</subject><subject>Reference Values</subject><subject>Relative Biological Effectiveness</subject><subject>Risk Assessment - methods</subject><issn>0144-8420</issn><issn>1742-3406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFuL1EAQRhtR3HH1L0gQ9C1jdfoa32RRR1xQvID40tR0ujFrko59gfHf2zLBxSefCqpOVX0cQp5Q2FPo2fNw8iEON6HEBae0j-uwRwBJtbxDdlTxrmUc5F2yA8p5q3kHF-RBSjcAneoFv08uKBdSqK7fkcOHqeSwjGVubFiyW3ITfPO9zLg064S2NnBq8phScalBn11sgrVlxTyG-r5xpzWkEt1Dcs_XNO7RVi_Jl9evPl8d2uv3b95evbxuLecit8pranuNDIF3TA49V5JTkN4J6xDs4KRA7SztjxIGySwoqRhzTskBj35gl-TZ-e4aw8-aKZt5TNZNEy4ulGSo1j3TQP8PcqkFiK6CL86gjSGl6LxZ4zhj_GUomD_Czb_CTRVuNuF1-fH2pRxnN9yuboYr8HQDMFmcfMTFjumWE7TjulOVa8_cmLI7_Z1j_GGqACXM4es3oz_xA__4ThvGfgM-56Bj</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>RUSSELL, J. J</creator><creator>SIKOV, M. R</creator><creator>KATHREN, R. L</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope></search><sort><creationdate>20030101</creationdate><title>Plutonium content of human placental tissues after occupational exposure</title><author>RUSSELL, J. J ; SIKOV, M. R ; KATHREN, R. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-7f81c98a3a04236d94764106fe5cea0cde65a8ec19b60d63c076733ee76dabfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Body Burden</topic><topic>Computer Simulation</topic><topic>Female</topic><topic>Humans</topic><topic>Maternal Exposure</topic><topic>Maternal-Fetal Exchange</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Nuclear Reactors</topic><topic>Occupational Exposure - analysis</topic><topic>Placenta - metabolism</topic><topic>Plutonium - analysis</topic><topic>Plutonium - pharmacokinetics</topic><topic>Pregnancy</topic><topic>Radiation Dosage</topic><topic>Radioactive Hazard Release</topic><topic>Radiometry - methods</topic><topic>Reference Values</topic><topic>Relative Biological Effectiveness</topic><topic>Risk Assessment - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RUSSELL, J. J</creatorcontrib><creatorcontrib>SIKOV, M. R</creatorcontrib><creatorcontrib>KATHREN, R. L</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><jtitle>Radiation protection dosimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RUSSELL, J. J</au><au>SIKOV, M. R</au><au>KATHREN, R. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plutonium content of human placental tissues after occupational exposure</atitle><jtitle>Radiation protection dosimetry</jtitle><addtitle>Radiat Prot Dosimetry</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>104</volume><issue>3</issue><spage>231</spage><epage>236</epage><pages>231-236</pages><issn>0144-8420</issn><eissn>1742-3406</eissn><coden>RPDODE</coden><abstract>The placenta and umbilical cord were obtained following a normal live delivery from a volunteer donor who had received an accidental inhalation intake of plutonium 12 years prior to her pregnancy (Case 0777). Her employer estimated the intake to be about 73 Bq Class W plutonium. Based on bioassay results and clearance models in use at that time, they calculated her body content at the beginning of pregnancy to be about 5.6 Bq with an average concentration of approximately 60 mBq kg-1. The placenta and cord from this pregnancy, along with the placenta and cord from a donor with no known exposure to plutonium (Case 0835), were divided and assayed for plutonium by ultrasensitive fission track analysis at two collaborating laboratories. Placental 239Pu concentration values obtained by the two laboratories for Case 0777 agreed within a factor of 2 and were several-fold greater than for the control, Case 0835, as well as values that had been reported by others for unexposed populations. There was no elevated concentration of plutonium in the umbilical cord from the exposed person. The data yielded values of 0.16 and 0.27 for placental to maternal concentrations (CPI:CM) that were of the same order of magnitude as the value of 0.1 the ICRP calculated for intakes before pregnancy.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>14565729</pmid><doi>10.1093/oxfordjournals.rpd.a006186</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Biological and medical sciences Body Burden Computer Simulation Female Humans Maternal Exposure Maternal-Fetal Exchange Medical sciences Models, Biological Nuclear Reactors Occupational Exposure - analysis Placenta - metabolism Plutonium - analysis Plutonium - pharmacokinetics Pregnancy Radiation Dosage Radioactive Hazard Release Radiometry - methods Reference Values Relative Biological Effectiveness Risk Assessment - methods |
| title | Plutonium content of human placental tissues after occupational exposure |
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