Epigallocatechin Gallate Modulates CYP450 Isoforms in the Female Swiss-Webster Mouse

This study was designed to determine the effect of the in vivo administration of epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) on enzymes involved in the synthesis and metabolism of estradiol. EGCG (12.5, 25, or 50 mg/kg/day, ip) or ECG (12.5 or 25 mg/kg/day, ip) was administered to...

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Veröffentlicht in:	Toxicological sciences 2003-12, Vol.76 (2), p.262-270
Hauptverfasser:	Goodin, Mette G., Rosengren, Rhonda J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Catechin - administration & dosage Catechin - analogs & derivatives Catechin - pharmacology catechol O-methyltransferase Catechol O-Methyltransferase - metabolism CYP19 CYP1A CYP3A Cytochrome P-450 Enzyme System - metabolism Dose-Response Relationship, Drug epigallocatechin gallate Female General aspects. Methods Injections, Intraperitoneal Kidney - drug effects Kidney - pathology Liver - drug effects Liver - enzymology Liver - pathology Longevity - drug effects Medical sciences Mice Necrosis Ovary - drug effects Ovary - enzymology Ovary - pathology Protein Isoforms Toxicology
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