In vivo identification of aflatoxin-induced free radicals in rat bile

Aflatoxin B1 (AFB1) is a potent hepatocarcinogen. We have recently detected [via electron spin resonance (ESR) spectroscopy] free radicals in vivo in rat bile following AFB1 metabolism using the spin trapping [α-(4-pyridyl-1-oxide)- N- tert-butyl nitrone (4-POBN)] technique. The aim of the present s...

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Veröffentlicht in:	Free radical biology & medicine 2003-11, Vol.35 (10), p.1330-1340
Hauptverfasser:	Towner, Rheal A, Qian, Steven Y, Kadiiska, Maria B, Mason, Ronald P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxin B1 - metabolism Aflatoxin B1 - toxicity Aflatoxin-B1 Aflatoxin-M1 Animals Anti-Inflammatory Agents - pharmacology Arachidonic Acid - chemistry Bile - chemistry Bile - metabolism Chromatography, High Pressure Liquid Cytochrome P-450 Enzyme Inhibitors Deferoxamine - analogs & derivatives Deferoxamine - pharmacology Desferoxamine mesylate Dimethyl Sulfoxide Electron Spin Resonance Spectroscopy Enzyme Inhibitors - pharmacology Free radicals Free Radicals - metabolism Gadolinium - pharmacology Gadolinium chloride HPLC-ESR Hydroxyl radicals Iron Chelating Agents - pharmacology Lipid radicals Male Nitrogen Oxides Proadifen - pharmacology Pyridines Rats Rats, Sprague-Dawley SKF525A Spin Labels Spin Trapping
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