Ethnic contact urticaria to alcohol

Ethnic contact urticaria to alcohol

Aqueous ethnol solutions can induce delayed allergic reactivity in humans, and acetaldehyde and ethanol may show cross-reactivity. In earlier reports of 2 patients with contact urticaria to ethanol, 1 identified as "Vietnamese", it was found that primary but not secondary or tertiary alcoh...

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Veröffentlicht in:Contact dermatitis 1985-02, Vol.12 (2), p.118-120
Hauptverfasser: Wilkin, Jonathan K., Fortner, Glenn
Format: Artikel
Sprache:eng
Schlagworte:
alcohol
Alcohols - adverse effects
Asian Continental Ancestry Group
Contact urticaria
ethnic group
Humans
Patch Tests
Urticaria - chemically induced
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container_title Contact dermatitis
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creator Wilkin, Jonathan K.
Fortner, Glenn
description Aqueous ethnol solutions can induce delayed allergic reactivity in humans, and acetaldehyde and ethanol may show cross-reactivity. In earlier reports of 2 patients with contact urticaria to ethanol, 1 identified as "Vietnamese", it was found that primary but not secondary or tertiary alcohols provoked the reaction. Since primary, and not secondary or tertiary alcohols are converted by alcohol dehydrogenase to the corresponding aldehyde, it is possible that the reaction is really provoked by the aldehyde. Since the current theory on Oriental flushing attributes the reaction a slow aldehyde reductase and subsequent accumulation of acetaldehyde after drinking alcohol. The authors investigated a cutaneous model of this sensitivity. The theoretical basis is strong, since the abnormal aldehyde reductase is found in both cultured skin fibroblasts and hair roots.
doi_str_mv 10.1111/j.1600-0536.1985.tb01073.x
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subjects alcohol
Alcohols - adverse effects
Asian Continental Ancestry Group
Contact urticaria
ethnic group
Humans
Patch Tests
Urticaria - chemically induced
title Ethnic contact urticaria to alcohol
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