Perturbation of Akt Signaling, Mitochondrial Potential, and ADP/ATP Ratio in Acidosis‐Challenged Rat Cortical Astrocytes

ABSTRACT Cells switch to anaerobic glycolysis when there is a lack of oxygen during brain ischemia. Extracellular pH thus drops and such acidosis causes neuronal cell death. The fate of astrocytes, mechanical, and functional partners of neurons, in acidosis is less studied. In this report, we invest...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cellular biochemistry 2017-05, Vol.118 (5), p.1108-1117
Hauptverfasser:	Wu, King‐Chuen, Cheng, Ka‐Shun, Wang, Yu‐Wen, Chen, Yuh‐Fung, Wong, Kar‐Lok, Su, Tzu‐Hui, Chan, Paul, Leung, Yuk‐Man
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDOSIS Acids - toxicity Adenosine diphosphate Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism AKT AKT protein Animals Apoptosis ASTROCYTES Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Brain Calcium - metabolism Calcium influx Calcium ions Cell death Cell Survival Cells, Cultured Chelation Cortex Cytotoxicity Gangrene Glycolysis Hyperpolarization Ischemia MAP kinase Membrane potential Membrane Potential, Mitochondrial - drug effects Mitochondria Mitochondria - drug effects Mitochondria - metabolism MITOCHONDRIA HYPERPOLARIZATION Mortality Necrosis Perturbation pH effects Proto-Oncogene Proteins c-akt - metabolism Rats Reactive Oxygen Species - metabolism Signal Transduction - drug effects Signaling Toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!