Ovariectomy increases the age-induced hyperphosphorylation of Tau at hippocampal CA1

One of the main hallmarks of Alzheimer’s disease includes the neurofibrillary tangles formation produced by hyperphosphorylation of the Tau protein, whose expression is putatively regulated by the ovarian hormones estradiol and progesterone. Hippocampus is a brain region that participates in many fu...

Ausführliche Beschreibung