Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men - a genotypic approach
Prostate cancer is one of the most significant health concerns for men worldwide. Numerous researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the overall risk and prognosis of this disease. Single n...
Gespeichert in:
| Veröffentlicht in: | Molecular bioSystems 2017-03, Vol.13 (4), p.681-698 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 698 |
|---|---|
| container_issue | 4 |
| container_start_page | 681 |
| container_title | Molecular bioSystems |
| container_volume | 13 |
| creator | Vaidyanathan, Venkatesh Naidu, Vijay Kao, Chi Hsiu-Juei Karunasinghe, Nishi Bishop, Karen S Wang, Alice Pallati, Radha Shepherd, Phillip Masters, Jonathan Zhu, Shuotun Goudie, Megan Krishnan, Mohanraj Jabed, Anower Marlow, Gareth Narayanan, Ajit Ferguson, Lynnette R |
| description | Prostate cancer is one of the most significant health concerns for men worldwide. Numerous researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the overall risk and prognosis of this disease. Single nucleotide polymorphisms (SNPs) are increasingly becoming strong biomarker candidates to identify susceptibility to prostate cancer. We carried out a gene × environment interaction analysis linked to aggressive and non-aggressive prostate cancer (PCa) with a number of SNPs. By using this method, we identified the susceptible alleles in a New Zealand population, and examined the interaction with environmental factors. We have identified a number of SNPs that have risk associations both with and without environmental interaction. The results indicate that certain SNPs are associated with disease vulnerability based on behavioral factors. The list of genes with SNPs identified as being associated with the risk of PCa in a New Zealand population is provided in the graphical abstract. |
| doi_str_mv | 10.1039/c6mb00873a |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1888975291</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1873723296</sourcerecordid><originalsourceid>FETCH-LOGICAL-c397t-51e2d94e36621f049a132c84293959e5dbb8e29875dfc0d1fae617c6f6686ac43</originalsourceid><addsrcrecordid>eNqNkclOwzAQhi0EomwXHgD5iJACXhLHPpaKTWK5gIS4RFNnUgJJHOwU1LfHpdAzp5nDN9-M5ifkkLNTzqQ5s6qdMqZzCRtkh-epSATL-Oa6V88jshvCG2NSp5xtk5HQIhNcih2yuOg-a--6FrsBGlqBHZwPFLqS-jq8U1dRmM08hlB_Iu29CwMMSC10Fj2F1nUzCrR3_byBoXbdcuAev-gLQrOURC9NIjHDzg2LvrYU-mgB-7pPtipoAh781j3ydHnxOLlObh-ubibj28RKkw9JxlGUJkWplOAVSw3Eu61OhZEmM5iV06lGYXSelZVlJa8AFc-tqpTSCmwq98jxyhvXfswxDEVbB4tNPA_dPBRca23yTBj-DzSXuZDCqIierFAbXxI8VkXv6xb8ouCsWKZSTNTd-U8q4wgf_Xrn0xbLNfoXg_wGTVuIEA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1873723296</pqid></control><display><type>article</type><title>Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men - a genotypic approach</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Vaidyanathan, Venkatesh ; Naidu, Vijay ; Kao, Chi Hsiu-Juei ; Karunasinghe, Nishi ; Bishop, Karen S ; Wang, Alice ; Pallati, Radha ; Shepherd, Phillip ; Masters, Jonathan ; Zhu, Shuotun ; Goudie, Megan ; Krishnan, Mohanraj ; Jabed, Anower ; Marlow, Gareth ; Narayanan, Ajit ; Ferguson, Lynnette R</creator><creatorcontrib>Vaidyanathan, Venkatesh ; Naidu, Vijay ; Kao, Chi Hsiu-Juei ; Karunasinghe, Nishi ; Bishop, Karen S ; Wang, Alice ; Pallati, Radha ; Shepherd, Phillip ; Masters, Jonathan ; Zhu, Shuotun ; Goudie, Megan ; Krishnan, Mohanraj ; Jabed, Anower ; Marlow, Gareth ; Narayanan, Ajit ; Ferguson, Lynnette R</creatorcontrib><description>Prostate cancer is one of the most significant health concerns for men worldwide. Numerous researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the overall risk and prognosis of this disease. Single nucleotide polymorphisms (SNPs) are increasingly becoming strong biomarker candidates to identify susceptibility to prostate cancer. We carried out a gene × environment interaction analysis linked to aggressive and non-aggressive prostate cancer (PCa) with a number of SNPs. By using this method, we identified the susceptible alleles in a New Zealand population, and examined the interaction with environmental factors. We have identified a number of SNPs that have risk associations both with and without environmental interaction. The results indicate that certain SNPs are associated with disease vulnerability based on behavioral factors. The list of genes with SNPs identified as being associated with the risk of PCa in a New Zealand population is provided in the graphical abstract.</description><identifier>ISSN: 1742-206X</identifier><identifier>EISSN: 1742-2051</identifier><identifier>DOI: 10.1039/c6mb00873a</identifier><identifier>PMID: 28252132</identifier><language>eng</language><publisher>England</publisher><subject>Alleles ; Case-Control Studies ; Environment ; Gene-Environment Interaction ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Life Style ; Male ; Neoplasm Grading ; New Zealand - epidemiology ; Odds Ratio ; Polymorphism, Single Nucleotide ; Population Surveillance ; Prognosis ; Prostatic Neoplasms - etiology ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - pathology ; Risk Assessment ; Risk Factors</subject><ispartof>Molecular bioSystems, 2017-03, Vol.13 (4), p.681-698</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-51e2d94e36621f049a132c84293959e5dbb8e29875dfc0d1fae617c6f6686ac43</citedby><cites>FETCH-LOGICAL-c397t-51e2d94e36621f049a132c84293959e5dbb8e29875dfc0d1fae617c6f6686ac43</cites><orcidid>0000-0003-4935-7708 ; 0000-0002-9299-617X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28252132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaidyanathan, Venkatesh</creatorcontrib><creatorcontrib>Naidu, Vijay</creatorcontrib><creatorcontrib>Kao, Chi Hsiu-Juei</creatorcontrib><creatorcontrib>Karunasinghe, Nishi</creatorcontrib><creatorcontrib>Bishop, Karen S</creatorcontrib><creatorcontrib>Wang, Alice</creatorcontrib><creatorcontrib>Pallati, Radha</creatorcontrib><creatorcontrib>Shepherd, Phillip</creatorcontrib><creatorcontrib>Masters, Jonathan</creatorcontrib><creatorcontrib>Zhu, Shuotun</creatorcontrib><creatorcontrib>Goudie, Megan</creatorcontrib><creatorcontrib>Krishnan, Mohanraj</creatorcontrib><creatorcontrib>Jabed, Anower</creatorcontrib><creatorcontrib>Marlow, Gareth</creatorcontrib><creatorcontrib>Narayanan, Ajit</creatorcontrib><creatorcontrib>Ferguson, Lynnette R</creatorcontrib><title>Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men - a genotypic approach</title><title>Molecular bioSystems</title><addtitle>Mol Biosyst</addtitle><description>Prostate cancer is one of the most significant health concerns for men worldwide. Numerous researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the overall risk and prognosis of this disease. Single nucleotide polymorphisms (SNPs) are increasingly becoming strong biomarker candidates to identify susceptibility to prostate cancer. We carried out a gene × environment interaction analysis linked to aggressive and non-aggressive prostate cancer (PCa) with a number of SNPs. By using this method, we identified the susceptible alleles in a New Zealand population, and examined the interaction with environmental factors. We have identified a number of SNPs that have risk associations both with and without environmental interaction. The results indicate that certain SNPs are associated with disease vulnerability based on behavioral factors. The list of genes with SNPs identified as being associated with the risk of PCa in a New Zealand population is provided in the graphical abstract.</description><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Environment</subject><subject>Gene-Environment Interaction</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Life Style</subject><subject>Male</subject><subject>Neoplasm Grading</subject><subject>New Zealand - epidemiology</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population Surveillance</subject><subject>Prognosis</subject><subject>Prostatic Neoplasms - etiology</subject><subject>Prostatic Neoplasms - mortality</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>1742-206X</issn><issn>1742-2051</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkclOwzAQhi0EomwXHgD5iJACXhLHPpaKTWK5gIS4RFNnUgJJHOwU1LfHpdAzp5nDN9-M5ifkkLNTzqQ5s6qdMqZzCRtkh-epSATL-Oa6V88jshvCG2NSp5xtk5HQIhNcih2yuOg-a--6FrsBGlqBHZwPFLqS-jq8U1dRmM08hlB_Iu29CwMMSC10Fj2F1nUzCrR3_byBoXbdcuAev-gLQrOURC9NIjHDzg2LvrYU-mgB-7pPtipoAh781j3ydHnxOLlObh-ubibj28RKkw9JxlGUJkWplOAVSw3Eu61OhZEmM5iV06lGYXSelZVlJa8AFc-tqpTSCmwq98jxyhvXfswxDEVbB4tNPA_dPBRca23yTBj-DzSXuZDCqIierFAbXxI8VkXv6xb8ouCsWKZSTNTd-U8q4wgf_Xrn0xbLNfoXg_wGTVuIEA</recordid><startdate>20170328</startdate><enddate>20170328</enddate><creator>Vaidyanathan, Venkatesh</creator><creator>Naidu, Vijay</creator><creator>Kao, Chi Hsiu-Juei</creator><creator>Karunasinghe, Nishi</creator><creator>Bishop, Karen S</creator><creator>Wang, Alice</creator><creator>Pallati, Radha</creator><creator>Shepherd, Phillip</creator><creator>Masters, Jonathan</creator><creator>Zhu, Shuotun</creator><creator>Goudie, Megan</creator><creator>Krishnan, Mohanraj</creator><creator>Jabed, Anower</creator><creator>Marlow, Gareth</creator><creator>Narayanan, Ajit</creator><creator>Ferguson, Lynnette R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-4935-7708</orcidid><orcidid>https://orcid.org/0000-0002-9299-617X</orcidid></search><sort><creationdate>20170328</creationdate><title>Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men - a genotypic approach</title><author>Vaidyanathan, Venkatesh ; Naidu, Vijay ; Kao, Chi Hsiu-Juei ; Karunasinghe, Nishi ; Bishop, Karen S ; Wang, Alice ; Pallati, Radha ; Shepherd, Phillip ; Masters, Jonathan ; Zhu, Shuotun ; Goudie, Megan ; Krishnan, Mohanraj ; Jabed, Anower ; Marlow, Gareth ; Narayanan, Ajit ; Ferguson, Lynnette R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-51e2d94e36621f049a132c84293959e5dbb8e29875dfc0d1fae617c6f6686ac43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Environment</topic><topic>Gene-Environment Interaction</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Life Style</topic><topic>Male</topic><topic>Neoplasm Grading</topic><topic>New Zealand - epidemiology</topic><topic>Odds Ratio</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population Surveillance</topic><topic>Prognosis</topic><topic>Prostatic Neoplasms - etiology</topic><topic>Prostatic Neoplasms - mortality</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaidyanathan, Venkatesh</creatorcontrib><creatorcontrib>Naidu, Vijay</creatorcontrib><creatorcontrib>Kao, Chi Hsiu-Juei</creatorcontrib><creatorcontrib>Karunasinghe, Nishi</creatorcontrib><creatorcontrib>Bishop, Karen S</creatorcontrib><creatorcontrib>Wang, Alice</creatorcontrib><creatorcontrib>Pallati, Radha</creatorcontrib><creatorcontrib>Shepherd, Phillip</creatorcontrib><creatorcontrib>Masters, Jonathan</creatorcontrib><creatorcontrib>Zhu, Shuotun</creatorcontrib><creatorcontrib>Goudie, Megan</creatorcontrib><creatorcontrib>Krishnan, Mohanraj</creatorcontrib><creatorcontrib>Jabed, Anower</creatorcontrib><creatorcontrib>Marlow, Gareth</creatorcontrib><creatorcontrib>Narayanan, Ajit</creatorcontrib><creatorcontrib>Ferguson, Lynnette R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Molecular bioSystems</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaidyanathan, Venkatesh</au><au>Naidu, Vijay</au><au>Kao, Chi Hsiu-Juei</au><au>Karunasinghe, Nishi</au><au>Bishop, Karen S</au><au>Wang, Alice</au><au>Pallati, Radha</au><au>Shepherd, Phillip</au><au>Masters, Jonathan</au><au>Zhu, Shuotun</au><au>Goudie, Megan</au><au>Krishnan, Mohanraj</au><au>Jabed, Anower</au><au>Marlow, Gareth</au><au>Narayanan, Ajit</au><au>Ferguson, Lynnette R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men - a genotypic approach</atitle><jtitle>Molecular bioSystems</jtitle><addtitle>Mol Biosyst</addtitle><date>2017-03-28</date><risdate>2017</risdate><volume>13</volume><issue>4</issue><spage>681</spage><epage>698</epage><pages>681-698</pages><issn>1742-206X</issn><eissn>1742-2051</eissn><abstract>Prostate cancer is one of the most significant health concerns for men worldwide. Numerous researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the overall risk and prognosis of this disease. Single nucleotide polymorphisms (SNPs) are increasingly becoming strong biomarker candidates to identify susceptibility to prostate cancer. We carried out a gene × environment interaction analysis linked to aggressive and non-aggressive prostate cancer (PCa) with a number of SNPs. By using this method, we identified the susceptible alleles in a New Zealand population, and examined the interaction with environmental factors. We have identified a number of SNPs that have risk associations both with and without environmental interaction. The results indicate that certain SNPs are associated with disease vulnerability based on behavioral factors. The list of genes with SNPs identified as being associated with the risk of PCa in a New Zealand population is provided in the graphical abstract.</abstract><cop>England</cop><pmid>28252132</pmid><doi>10.1039/c6mb00873a</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0003-4935-7708</orcidid><orcidid>https://orcid.org/0000-0002-9299-617X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1742-206X |
| ispartof | Molecular bioSystems, 2017-03, Vol.13 (4), p.681-698 |
| issn | 1742-206X 1742-2051 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1888975291 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Alleles Case-Control Studies Environment Gene-Environment Interaction Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Life Style Male Neoplasm Grading New Zealand - epidemiology Odds Ratio Polymorphism, Single Nucleotide Population Surveillance Prognosis Prostatic Neoplasms - etiology Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Risk Assessment Risk Factors |
| title | Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men - a genotypic approach |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T11%3A32%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Environmental%20factors%20and%20risk%20of%20aggressive%20prostate%20cancer%20among%20a%20population%20of%20New%20Zealand%20men%20-%20a%20genotypic%20approach&rft.jtitle=Molecular%20bioSystems&rft.au=Vaidyanathan,%20Venkatesh&rft.date=2017-03-28&rft.volume=13&rft.issue=4&rft.spage=681&rft.epage=698&rft.pages=681-698&rft.issn=1742-206X&rft.eissn=1742-2051&rft_id=info:doi/10.1039/c6mb00873a&rft_dat=%3Cproquest_cross%3E1873723296%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1873723296&rft_id=info:pmid/28252132&rfr_iscdi=true |