A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study
Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in t...
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| Veröffentlicht in: | Brain tumor pathology 2016-01, Vol.33 (1), p.63-70 |
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| creator | Yuzawa, Sayaka Nishihara, Hiroshi Tanino, Mishie Kimura, Taichi Moriya, Jun Kamoshima, Yuuta Nagashima, Kazuo Tanaka, Shinya |
| description | Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8 %. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor. |
| doi_str_mv | 10.1007/s10014-015-0241-5 |
| format | Article |
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Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8 %. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor.</description><identifier>ISSN: 1433-7398</identifier><identifier>EISSN: 1861-387X</identifier><identifier>DOI: 10.1007/s10014-015-0241-5</identifier><identifier>PMID: 26614252</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adolescent ; Antigens ; Biomarkers, Tumor - analysis ; Blood vessels ; Brain Neoplasms - diagnosis ; Brain Neoplasms - pathology ; Brain Neoplasms - surgery ; Brain Neoplasms - ultrastructure ; Calcification ; Cancer Research ; Case Report ; Cysts ; Cytokeratin ; Cytoplasm ; Edema ; Female ; Females ; Follow-Up Studies ; Glial Fibrillary Acidic Protein - analysis ; Humans ; Keratins - analysis ; Ki-67 Antigen - analysis ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Mucin-1 - analysis ; Neoplasm Grading ; Neoplasms, Neuroepithelial - diagnosis ; Neoplasms, Neuroepithelial - pathology ; Neoplasms, Neuroepithelial - surgery ; Neoplasms, Neuroepithelial - ultrastructure ; Neurology ; Neurosurgery ; Oncology ; Pathology ; Proteins ; Rhabdoid Tumor ; Tomography ; Treatment Outcome ; Vimentin - analysis ; Young adults</subject><ispartof>Brain tumor pathology, 2016-01, Vol.33 (1), p.63-70</ispartof><rights>The Japan Society of Brain Tumor Pathology 2015</rights><rights>The Japan Society of Brain Tumor Pathology 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-9d905ec511556dd26e5dff80b224366d3d97183d6bd7c731044b475fee1a36433</citedby><cites>FETCH-LOGICAL-c543t-9d905ec511556dd26e5dff80b224366d3d97183d6bd7c731044b475fee1a36433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10014-015-0241-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918133713?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21386,21387,27922,27923,33528,33529,33742,33743,41486,42555,43657,43803,51317,64383,64385,64387,72239</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26614252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuzawa, Sayaka</creatorcontrib><creatorcontrib>Nishihara, Hiroshi</creatorcontrib><creatorcontrib>Tanino, Mishie</creatorcontrib><creatorcontrib>Kimura, Taichi</creatorcontrib><creatorcontrib>Moriya, Jun</creatorcontrib><creatorcontrib>Kamoshima, Yuuta</creatorcontrib><creatorcontrib>Nagashima, Kazuo</creatorcontrib><creatorcontrib>Tanaka, Shinya</creatorcontrib><title>A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study</title><title>Brain tumor pathology</title><addtitle>Brain Tumor Pathol</addtitle><addtitle>Brain Tumor Pathol</addtitle><description>Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8 %. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor.</description><subject>Adolescent</subject><subject>Antigens</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Blood vessels</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - surgery</subject><subject>Brain Neoplasms - ultrastructure</subject><subject>Calcification</subject><subject>Cancer Research</subject><subject>Case Report</subject><subject>Cysts</subject><subject>Cytokeratin</subject><subject>Cytoplasm</subject><subject>Edema</subject><subject>Female</subject><subject>Females</subject><subject>Follow-Up Studies</subject><subject>Glial Fibrillary Acidic Protein - analysis</subject><subject>Humans</subject><subject>Keratins - analysis</subject><subject>Ki-67 Antigen - analysis</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mucin-1 - analysis</subject><subject>Neoplasm Grading</subject><subject>Neoplasms, Neuroepithelial - diagnosis</subject><subject>Neoplasms, Neuroepithelial - pathology</subject><subject>Neoplasms, Neuroepithelial - surgery</subject><subject>Neoplasms, Neuroepithelial - ultrastructure</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Proteins</subject><subject>Rhabdoid Tumor</subject><subject>Tomography</subject><subject>Treatment Outcome</subject><subject>Vimentin - analysis</subject><subject>Young adults</subject><issn>1433-7398</issn><issn>1861-387X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkU1rFTEUhoNUbK3-gG4k0E0Xjubke7orxS8ouFFwFzLJmd4pM5M2maHcf99cb9UiiJucJOc57-HlJeQE2DtgzLwv9QTZMFAN4xIa9YwcgdXQCGt-HNS7FKIxorWH5GUpN4xJyQy8IIdca5Bc8SNSLmjwBWnqacCMXfYj9WXJqRtrSZOn98OyoXnju5iGSHv0y5qxnFNPw3ZJY7oegh_f0s1Qnrz8HOkwTeucfv6HDU67Bi3LGrevyPPejwVfP9Zj8v3jh2-Xn5urr5--XF5cNUFJsTRtbJnCoACU0jFyjSr2vWUd51JoHUVsDVgRdRdNMAKqu04a1SOCF7paPyZne93bnO5WLIubhhJwHP2MaS0OrLWt4W2r_48aJRUHa3hFT_9Cb9Ka52rE8RYsCGFgtxv2VMiplIy9u83D5PPWAXO78Nw-PFfDc7vwnKozbx6V127C-HviV1oV4Hug1NZ8jfnP6n-rPgA94qQ-</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Yuzawa, Sayaka</creator><creator>Nishihara, Hiroshi</creator><creator>Tanino, Mishie</creator><creator>Kimura, Taichi</creator><creator>Moriya, Jun</creator><creator>Kamoshima, Yuuta</creator><creator>Nagashima, Kazuo</creator><creator>Tanaka, Shinya</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160101</creationdate><title>A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study</title><author>Yuzawa, Sayaka ; Nishihara, Hiroshi ; Tanino, Mishie ; Kimura, Taichi ; Moriya, Jun ; Kamoshima, Yuuta ; Nagashima, Kazuo ; Tanaka, Shinya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-9d905ec511556dd26e5dff80b224366d3d97183d6bd7c731044b475fee1a36433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Antigens</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Blood vessels</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - surgery</topic><topic>Brain Neoplasms - ultrastructure</topic><topic>Calcification</topic><topic>Cancer Research</topic><topic>Case Report</topic><topic>Cysts</topic><topic>Cytokeratin</topic><topic>Cytoplasm</topic><topic>Edema</topic><topic>Female</topic><topic>Females</topic><topic>Follow-Up Studies</topic><topic>Glial Fibrillary Acidic Protein - analysis</topic><topic>Humans</topic><topic>Keratins - analysis</topic><topic>Ki-67 Antigen - analysis</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mucin-1 - analysis</topic><topic>Neoplasm Grading</topic><topic>Neoplasms, Neuroepithelial - diagnosis</topic><topic>Neoplasms, Neuroepithelial - pathology</topic><topic>Neoplasms, Neuroepithelial - surgery</topic><topic>Neoplasms, Neuroepithelial - ultrastructure</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Proteins</topic><topic>Rhabdoid Tumor</topic><topic>Tomography</topic><topic>Treatment Outcome</topic><topic>Vimentin - analysis</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuzawa, Sayaka</creatorcontrib><creatorcontrib>Nishihara, Hiroshi</creatorcontrib><creatorcontrib>Tanino, Mishie</creatorcontrib><creatorcontrib>Kimura, Taichi</creatorcontrib><creatorcontrib>Moriya, Jun</creatorcontrib><creatorcontrib>Kamoshima, Yuuta</creatorcontrib><creatorcontrib>Nagashima, Kazuo</creatorcontrib><creatorcontrib>Tanaka, Shinya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain tumor pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuzawa, Sayaka</au><au>Nishihara, Hiroshi</au><au>Tanino, Mishie</au><au>Kimura, Taichi</au><au>Moriya, Jun</au><au>Kamoshima, Yuuta</au><au>Nagashima, Kazuo</au><au>Tanaka, Shinya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study</atitle><jtitle>Brain tumor pathology</jtitle><stitle>Brain Tumor Pathol</stitle><addtitle>Brain Tumor Pathol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>33</volume><issue>1</issue><spage>63</spage><epage>70</epage><pages>63-70</pages><issn>1433-7398</issn><eissn>1861-387X</eissn><abstract>Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8 %. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>26614252</pmid><doi>10.1007/s10014-015-0241-5</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Antigens Biomarkers, Tumor - analysis Blood vessels Brain Neoplasms - diagnosis Brain Neoplasms - pathology Brain Neoplasms - surgery Brain Neoplasms - ultrastructure Calcification Cancer Research Case Report Cysts Cytokeratin Cytoplasm Edema Female Females Follow-Up Studies Glial Fibrillary Acidic Protein - analysis Humans Keratins - analysis Ki-67 Antigen - analysis Magnetic resonance imaging Medicine Medicine & Public Health Mucin-1 - analysis Neoplasm Grading Neoplasms, Neuroepithelial - diagnosis Neoplasms, Neuroepithelial - pathology Neoplasms, Neuroepithelial - surgery Neoplasms, Neuroepithelial - ultrastructure Neurology Neurosurgery Oncology Pathology Proteins Rhabdoid Tumor Tomography Treatment Outcome Vimentin - analysis Young adults |
| title | A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study |
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