Aluminium allergy in patients hyposensitized with aluminium-precipitated antigen extracts
During hyposensitization therapy with aluminium‐precipitated antigen solutions, a small % of patients develop persistent subcutaneous nodules at the injection site; the existence of delayed sensitivity to aluminium has been implicated in the pathogenesis of these nodules. We studied the prevalence o...
Gespeichert in:
| Veröffentlicht in: | Contact dermatitis 1994-07, Vol.31 (1), p.37-40 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 40 |
|---|---|
| container_issue | 1 |
| container_start_page | 37 |
| container_title | Contact dermatitis |
| container_volume | 31 |
| creator | Lopez, S. Peláez, A. Navarro, L. A. Montesinos, E. Morales, C. Carda, C. |
| description | During hyposensitization therapy with aluminium‐precipitated antigen solutions, a small % of patients develop persistent subcutaneous nodules at the injection site; the existence of delayed sensitivity to aluminium has been implicated in the pathogenesis of these nodules. We studied the prevalence of aluminium sensitivity (using patch, prick and intradermal tests) and common contact allergens (TRUE Test™) in 20 healthy subjects, and in 40 patients treated with aluminium‐containing extracts, 20 of whom had persistent subcutaneous nodules that remained for more than 2 months, the other half having no nodular reactions or nodules that remained for less than 2 months. Aluminium sensitivity was found only in those patients of the treated group who had persistent nodular reactions, 4 cases of positivity to an aluminium chloride patch test being found. All 4 cases were women, nodules remained for more than 6 months, and intracutaneous tests were negative. 3 of them also had contact sensitivity to nickel. In 2 cases, nodules were removed for histological and histochemical examination, showing non‐specific inflammatory granulomas, and aluminium crystals being found in only 1 case. It is concluded that delayed sensitivity to aluminium appears to be implicated in the pathogenesis of persistent nodular reactions, but sensitivity to aluminium was not found in patients treated with aluminium‐precipitated extracts without persistent nodular reactions. |
| doi_str_mv | 10.1111/j.1600-0536.1994.tb01903.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1888971982</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1888971982</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4687-e1f710b455582ad2ed5a98071bc7d4c58896a23982ee834f56ffdac0ba5762f73</originalsourceid><addsrcrecordid>eNqVkM1u1DAUhS0EKkPhEZAixIJNgn_inyCxqGZoQRq1QipCrCzHuWk9JJlgO-oMT4-jiWaPN16c71xffwi9I7gg6XzcFURgnGPOREGqqixijUmFWXF4hlbn6DlaYYJ5TpRkL9GrEHYYE1FSdYEuZEVLWtEV-nXVTb0b3NRnpuvAPxwzN2SjiQ6GGLLH47gPMAQX3V9osicXHxO3NPLRg3WjiyamzAzRPcCQwSF6Y2N4jV60pgvwZrkv0Y_rL_frr_n27ubb-mqb21IomQNpJcF1yTlX1DQUGm4qhSWprWxKy5WqhKGsUhRAsbLlom0bY3FtuBS0lewSfTjNHf3-zwQh6t4FC11nBthPQROVRkiSBiT00wm1fh-Ch1aP3vXGHzXBejard3rWp2d9ejarF7P6kMpvl3emuofmXF1Upvz9kptgTdd6M1gXzlhJBBGUJ-zzCXtyHRz_YwG9vtuw-bv5qe9ChMO5b_xvLSSTXP-8vdHfbzneXt9v9Ib9AygOpgg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1888971982</pqid></control><display><type>article</type><title>Aluminium allergy in patients hyposensitized with aluminium-precipitated antigen extracts</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Lopez, S. ; Peláez, A. ; Navarro, L. A. ; Montesinos, E. ; Morales, C. ; Carda, C.</creator><creatorcontrib>Lopez, S. ; Peláez, A. ; Navarro, L. A. ; Montesinos, E. ; Morales, C. ; Carda, C.</creatorcontrib><description>During hyposensitization therapy with aluminium‐precipitated antigen solutions, a small % of patients develop persistent subcutaneous nodules at the injection site; the existence of delayed sensitivity to aluminium has been implicated in the pathogenesis of these nodules. We studied the prevalence of aluminium sensitivity (using patch, prick and intradermal tests) and common contact allergens (TRUE Test™) in 20 healthy subjects, and in 40 patients treated with aluminium‐containing extracts, 20 of whom had persistent subcutaneous nodules that remained for more than 2 months, the other half having no nodular reactions or nodules that remained for less than 2 months. Aluminium sensitivity was found only in those patients of the treated group who had persistent nodular reactions, 4 cases of positivity to an aluminium chloride patch test being found. All 4 cases were women, nodules remained for more than 6 months, and intracutaneous tests were negative. 3 of them also had contact sensitivity to nickel. In 2 cases, nodules were removed for histological and histochemical examination, showing non‐specific inflammatory granulomas, and aluminium crystals being found in only 1 case. It is concluded that delayed sensitivity to aluminium appears to be implicated in the pathogenesis of persistent nodular reactions, but sensitivity to aluminium was not found in patients treated with aluminium‐precipitated extracts without persistent nodular reactions.</description><identifier>ISSN: 0105-1873</identifier><identifier>EISSN: 1600-0536</identifier><identifier>DOI: 10.1111/j.1600-0536.1994.tb01903.x</identifier><identifier>PMID: 7924292</identifier><identifier>CODEN: CODEDG</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; aluminium ; Aluminum - adverse effects ; Antigens - administration & dosage ; Biological and medical sciences ; Chemical Precipitation ; delayed hypersensitivity ; Desensitization, Immunologic - adverse effects ; Female ; Humans ; Hypersensitivity, Delayed - diagnosis ; Hypersensitivity, Delayed - etiology ; Immunopathology ; immunotherapy ; Immunotherapy (general aspects) ; Male ; Medical sciences ; Middle Aged ; negative intradermal tests ; negative prick tests ; persistent subcutaneous nodules ; positive patch tests ; side-effects ; Skin Tests</subject><ispartof>Contact dermatitis, 1994-07, Vol.31 (1), p.37-40</ispartof><rights>1994 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4687-e1f710b455582ad2ed5a98071bc7d4c58896a23982ee834f56ffdac0ba5762f73</citedby><cites>FETCH-LOGICAL-c4687-e1f710b455582ad2ed5a98071bc7d4c58896a23982ee834f56ffdac0ba5762f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0536.1994.tb01903.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0536.1994.tb01903.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4161625$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7924292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopez, S.</creatorcontrib><creatorcontrib>Peláez, A.</creatorcontrib><creatorcontrib>Navarro, L. A.</creatorcontrib><creatorcontrib>Montesinos, E.</creatorcontrib><creatorcontrib>Morales, C.</creatorcontrib><creatorcontrib>Carda, C.</creatorcontrib><title>Aluminium allergy in patients hyposensitized with aluminium-precipitated antigen extracts</title><title>Contact dermatitis</title><addtitle>Contact Dermatitis</addtitle><description>During hyposensitization therapy with aluminium‐precipitated antigen solutions, a small % of patients develop persistent subcutaneous nodules at the injection site; the existence of delayed sensitivity to aluminium has been implicated in the pathogenesis of these nodules. We studied the prevalence of aluminium sensitivity (using patch, prick and intradermal tests) and common contact allergens (TRUE Test™) in 20 healthy subjects, and in 40 patients treated with aluminium‐containing extracts, 20 of whom had persistent subcutaneous nodules that remained for more than 2 months, the other half having no nodular reactions or nodules that remained for less than 2 months. Aluminium sensitivity was found only in those patients of the treated group who had persistent nodular reactions, 4 cases of positivity to an aluminium chloride patch test being found. All 4 cases were women, nodules remained for more than 6 months, and intracutaneous tests were negative. 3 of them also had contact sensitivity to nickel. In 2 cases, nodules were removed for histological and histochemical examination, showing non‐specific inflammatory granulomas, and aluminium crystals being found in only 1 case. It is concluded that delayed sensitivity to aluminium appears to be implicated in the pathogenesis of persistent nodular reactions, but sensitivity to aluminium was not found in patients treated with aluminium‐precipitated extracts without persistent nodular reactions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>aluminium</subject><subject>Aluminum - adverse effects</subject><subject>Antigens - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Chemical Precipitation</subject><subject>delayed hypersensitivity</subject><subject>Desensitization, Immunologic - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity, Delayed - diagnosis</subject><subject>Hypersensitivity, Delayed - etiology</subject><subject>Immunopathology</subject><subject>immunotherapy</subject><subject>Immunotherapy (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>negative intradermal tests</subject><subject>negative prick tests</subject><subject>persistent subcutaneous nodules</subject><subject>positive patch tests</subject><subject>side-effects</subject><subject>Skin Tests</subject><issn>0105-1873</issn><issn>1600-0536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1u1DAUhS0EKkPhEZAixIJNgn_inyCxqGZoQRq1QipCrCzHuWk9JJlgO-oMT4-jiWaPN16c71xffwi9I7gg6XzcFURgnGPOREGqqixijUmFWXF4hlbn6DlaYYJ5TpRkL9GrEHYYE1FSdYEuZEVLWtEV-nXVTb0b3NRnpuvAPxwzN2SjiQ6GGLLH47gPMAQX3V9osicXHxO3NPLRg3WjiyamzAzRPcCQwSF6Y2N4jV60pgvwZrkv0Y_rL_frr_n27ubb-mqb21IomQNpJcF1yTlX1DQUGm4qhSWprWxKy5WqhKGsUhRAsbLlom0bY3FtuBS0lewSfTjNHf3-zwQh6t4FC11nBthPQROVRkiSBiT00wm1fh-Ch1aP3vXGHzXBejard3rWp2d9ejarF7P6kMpvl3emuofmXF1Upvz9kptgTdd6M1gXzlhJBBGUJ-zzCXtyHRz_YwG9vtuw-bv5qe9ChMO5b_xvLSSTXP-8vdHfbzneXt9v9Ib9AygOpgg</recordid><startdate>199407</startdate><enddate>199407</enddate><creator>Lopez, S.</creator><creator>Peláez, A.</creator><creator>Navarro, L. A.</creator><creator>Montesinos, E.</creator><creator>Morales, C.</creator><creator>Carda, C.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>199407</creationdate><title>Aluminium allergy in patients hyposensitized with aluminium-precipitated antigen extracts</title><author>Lopez, S. ; Peláez, A. ; Navarro, L. A. ; Montesinos, E. ; Morales, C. ; Carda, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4687-e1f710b455582ad2ed5a98071bc7d4c58896a23982ee834f56ffdac0ba5762f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>aluminium</topic><topic>Aluminum - adverse effects</topic><topic>Antigens - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Chemical Precipitation</topic><topic>delayed hypersensitivity</topic><topic>Desensitization, Immunologic - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity, Delayed - diagnosis</topic><topic>Hypersensitivity, Delayed - etiology</topic><topic>Immunopathology</topic><topic>immunotherapy</topic><topic>Immunotherapy (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>negative intradermal tests</topic><topic>negative prick tests</topic><topic>persistent subcutaneous nodules</topic><topic>positive patch tests</topic><topic>side-effects</topic><topic>Skin Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopez, S.</creatorcontrib><creatorcontrib>Peláez, A.</creatorcontrib><creatorcontrib>Navarro, L. A.</creatorcontrib><creatorcontrib>Montesinos, E.</creatorcontrib><creatorcontrib>Morales, C.</creatorcontrib><creatorcontrib>Carda, C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Contact dermatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopez, S.</au><au>Peláez, A.</au><au>Navarro, L. A.</au><au>Montesinos, E.</au><au>Morales, C.</au><au>Carda, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aluminium allergy in patients hyposensitized with aluminium-precipitated antigen extracts</atitle><jtitle>Contact dermatitis</jtitle><addtitle>Contact Dermatitis</addtitle><date>1994-07</date><risdate>1994</risdate><volume>31</volume><issue>1</issue><spage>37</spage><epage>40</epage><pages>37-40</pages><issn>0105-1873</issn><eissn>1600-0536</eissn><coden>CODEDG</coden><abstract>During hyposensitization therapy with aluminium‐precipitated antigen solutions, a small % of patients develop persistent subcutaneous nodules at the injection site; the existence of delayed sensitivity to aluminium has been implicated in the pathogenesis of these nodules. We studied the prevalence of aluminium sensitivity (using patch, prick and intradermal tests) and common contact allergens (TRUE Test™) in 20 healthy subjects, and in 40 patients treated with aluminium‐containing extracts, 20 of whom had persistent subcutaneous nodules that remained for more than 2 months, the other half having no nodular reactions or nodules that remained for less than 2 months. Aluminium sensitivity was found only in those patients of the treated group who had persistent nodular reactions, 4 cases of positivity to an aluminium chloride patch test being found. All 4 cases were women, nodules remained for more than 6 months, and intracutaneous tests were negative. 3 of them also had contact sensitivity to nickel. In 2 cases, nodules were removed for histological and histochemical examination, showing non‐specific inflammatory granulomas, and aluminium crystals being found in only 1 case. It is concluded that delayed sensitivity to aluminium appears to be implicated in the pathogenesis of persistent nodular reactions, but sensitivity to aluminium was not found in patients treated with aluminium‐precipitated extracts without persistent nodular reactions.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7924292</pmid><doi>10.1111/j.1600-0536.1994.tb01903.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0105-1873 |
| ispartof | Contact dermatitis, 1994-07, Vol.31 (1), p.37-40 |
| issn | 0105-1873 1600-0536 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1888971982 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adolescent Adult aluminium Aluminum - adverse effects Antigens - administration & dosage Biological and medical sciences Chemical Precipitation delayed hypersensitivity Desensitization, Immunologic - adverse effects Female Humans Hypersensitivity, Delayed - diagnosis Hypersensitivity, Delayed - etiology Immunopathology immunotherapy Immunotherapy (general aspects) Male Medical sciences Middle Aged negative intradermal tests negative prick tests persistent subcutaneous nodules positive patch tests side-effects Skin Tests |
| title | Aluminium allergy in patients hyposensitized with aluminium-precipitated antigen extracts |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T05%3A38%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aluminium%20allergy%20in%20patients%20hyposensitized%20with%20aluminium-precipitated%20antigen%20extracts&rft.jtitle=Contact%20dermatitis&rft.au=Lopez,%20S.&rft.date=1994-07&rft.volume=31&rft.issue=1&rft.spage=37&rft.epage=40&rft.pages=37-40&rft.issn=0105-1873&rft.eissn=1600-0536&rft.coden=CODEDG&rft_id=info:doi/10.1111/j.1600-0536.1994.tb01903.x&rft_dat=%3Cproquest_cross%3E1888971982%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1888971982&rft_id=info:pmid/7924292&rfr_iscdi=true |