Effect of aging and Alzheimer's disease-like pathology on brain monoamines in mice

Aging is the greatest single risk factor of the neurodegenerative disorder Alzheimer's disease (AD). The monoaminergic system, including serotonin (5-HT), dopamine (DA) and noradrenaline (NA) modulates cognition, which is affected in AD. Changes in monoamine levels have been observed in AD, but...

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Veröffentlicht in:	Neurochemistry international 2017-09, Vol.108, p.238-245
Hauptverfasser:	Von Linstow, C.U., Severino, M., Metaxas, A., Waider, J., Babcock, A.A., Lesch, K.P., Gramsbergen, J.B., Finsen, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - metabolism Aging - pathology Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Protein Precursor - genetics Amyloid precursor protein/presenilin 1 Animals Biogenic Monoamines - metabolism Brain - metabolism Brain - pathology Brainstem Dopamine Male Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Transgenic Neocortex Noradrenaline Presenilin-1 - genetics Serotonin
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