Rifampicin as a novel tyrosinase inhibitor: Inhibitory activity and mechanism

[Display omitted] In this study, the inhibitory effect and mechanism of rifampicin on the activity of tyrosinase were investigated for developing a novel tyrosinase inhibitor. It was found to have a significant inhibition on the activity of tyrosinase (IC50=90±0.6μM). From the kinetics analysis, it...

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Veröffentlicht in:	International journal of biological macromolecules 2017-09, Vol.102, p.425-430
Hauptverfasser:	Chai, Wei-Ming, Lin, Mei-Zhen, Song, Fang-Jun, Wang, Ying-Xia, Xu, Kai-Li, Huang, Jin-Xin, Fu, Jian-Ping, Peng, Yi-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - enzymology Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Kinetics Mechanism Molecular Docking Simulation Monophenol Monooxygenase - antagonists & inhibitors Monophenol Monooxygenase - chemistry Monophenol Monooxygenase - metabolism Protein Conformation Rifampicin Rifampin - metabolism Rifampin - pharmacology Tyrosinase inhibitor
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