Fibrinolytic Enzyme Cotherapy Improves Tumor Perfusion and Therapeutic Efficacy of Anticancer Nanomedicine

Elevated interstitial fluid pressure and solid stress within tumors contribute to poor intratumoral distribution of nanomedicine. In this study, we hypothesized that the presence of fibrin in tumor extracellular matrix contributes to hindered intratumoral distribution of nanocarriers and that this c...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2017-03, Vol.77 (6), p.1465-1475
Hauptverfasser:	Kirtane, Ameya R, Sadhukha, Tanmoy, Kim, Hyunjoon, Khanna, Vidhi, Koniar, Brenda, Panyam, Jayanth
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - administration & dosage Animal models Animals Blood vessels Cancer Decompression Enzymes Extracellular matrix Female Fibrin Fibrin - metabolism Fibrinolysis Fibrinolytic Agents - pharmacology Fluid pressure Humans Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Melanoma Melanoma, Experimental - drug therapy Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice Mice, Inbred C57BL Nanomedicine Nanoparticles Nanotechnology Paclitaxel Paclitaxel - administration & dosage Perfusion Rodents Staining Stress concentration t-Plasminogen activator Tissue Plasminogen Activator - pharmacology Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays Xenografts
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