A novel strategy for global mapping of O-GlcNAc proteins and peptides using selective enzymatic deglycosylation, HILIC enrichment and mass spectrometry identification

O-GlcNAcylation is a kind of dynamic O-linked glycosylation of nucleocytoplasmic and mitochondrial proteins. It serves as a major nutrient sensor to regulate numerous biological processes including transcriptional regulation, cell metabolism, cellular signaling, and protein degradation. Dysregulatio...

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Veröffentlicht in:	Talanta (Oxford) 2017-07, Vol.169, p.195-202
Hauptverfasser:	Shen, Bingquan, Zhang, Wanjun, Shi, Zhaomei, Tian, Fang, Deng, Yulin, Sun, Changqing, Wang, Guangshun, Qin, Weijie, Qian, Xiaohong
Format:	Artikel
Sprache:	eng
Schlagworte:	HILIC enrichment O-GlcNAcylation Proteomics Selective enzymatic deglycosylation Urinary protein
Online-Zugang:	Volltext
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