Abstract 326: Discovery and in vitro and in vivo characterization of a novel, small-molecule Ras inhibitor class

Introduction: Mutations in ras genes that result in constitutive activation of Ras proteins are key drivers of oncogenesis, but no effective drugs have been developed that target these aberrant gene products. Through iterative screening and chemical optimization using a phenotypic assay designed to...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-07, Vol.76 (14_Supplement), p.326-326
Hauptverfasser:	Keeton, Adam B., Zhu, Bing, Lee, Kevin J., Canzoneri, Joshua C., Sigler, Sara C., Lindsey, Ashley S., Ramirez-Alcantara, Veronica, Barnes, Luciana, Mattox, Tyler E., McConnell, Kate, Berry, Kristy L., Valiyaveettil, Jacob, Chen, Xi, Boyd, Michael R., Piazza, Gary A.
Format:	Artikel
Sprache:	eng
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