Colonic N‐methyl‐d‐aspartate receptor contributes to visceral hypersensitivity in irritable bowel syndrome

Background and Aims N‐methyl‐d‐aspartate receptor (NMDAR) in brain, spinal cord, and enteric nervous system is involved in visceral hypersensitivity. This study aimed to reveal the functional expression of NMDAR on mucosal cells in colon and to investigate the downstream signal pathway from colonic...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 2017-04, Vol.32 (4), p.828-836
Hauptverfasser:	Qi, Qingqing, Chen, Feixue, Zhang, Wenxue, Wang, Peng, Li, Yanqing, Zuo, Xiuli
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Colon Colon - metabolism colon mucosa Distension Electromyography Enteric nervous system Extracellular signal-regulated kinase Female Glutamic acid receptors HT29 Cells Humans Hypersensitivity Immunohistochemistry Intestinal Mucosa - metabolism Intestine Irritable bowel syndrome Irritable Bowel Syndrome - physiopathology Male MAP Kinase Signaling System - physiology Metabolic pathways Mice Middle Aged Mucosa N-Methyl-D-aspartic acid receptors N-Methylaspartate - administration & dosage N-Methylaspartate - pharmacology N‐methyl‐d‐aspartate receptor Pain Receptors, N-Methyl-D-Aspartate - metabolism Receptors, N-Methyl-D-Aspartate - physiology Rodents Signal Transduction - physiology Spinal cord Surveys and Questionnaires Up-Regulation Viscera - physiopathology visceral hypersensitivity
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