Precise ratiometric loading of PTX and DOX based on redox-sensitive mixed micelles for cancer therapy

A new redox-sensitive drug delivery system with a precise ratiometric loading and different anticancer mechanisms (PTX and DOX) is constructed for cancer therapy. [Display omitted] •The ratio of PTX and DOX in the mixed micelles is precisely fixed.•The mixed micelles realize the redox-triggered rele...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2017-07, Vol.155, p.51-60
Hauptverfasser:	Zhao, Dujuan, Wu, Jilian, Li, Chuanxiang, Zhang, Huiyuan, Li, Zhonghao, Luan, Yuxia
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cancer therapy Cell Survival - drug effects Co-delivery Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers Drug Compounding - methods Drug Therapy, Combination Humans Injections, Intravenous Male Melanoma, Experimental - drug therapy Melanoma, Experimental - pathology Mice Micelles Mixed micelle Oxidation-Reduction Paclitaxel - chemistry Paclitaxel - pharmacology Polyethylene Glycols - chemistry Polymer-drug conjugate Redox-sensitive Skin Neoplasms - drug therapy Skin Neoplasms - pathology
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