Trifluoromethyl arylamides with antileukemia effect and intracellular inhibitory activity over serine/arginine-rich protein kinases (SRPKs)

The serine/arginine-rich protein kinases (SRPKs) have frequently been found with altered activity in a number of cancers, suggesting they could serve as potential therapeutic targets in oncology. Here we describe the synthesis of a series of twenty-two trifluoromethyl arylamides based on the known S...

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Veröffentlicht in:	European journal of medicinal chemistry 2017-07, Vol.134, p.97-109
Hauptverfasser:	Siqueira, Raoni Pais, Barros, Marcus Vinícius de Andrade, Barbosa, Éverton de Almeida Alves, Onofre, Thiago Souza, Gonçalves, Victor Hugo Sousa, Pereira, Higor Sette, Silva Júnior, Abelardo, de Oliveira, Leandro Licursi, Almeida, Márcia Rogéria, Fietto, Juliana Lopes Rangel, Teixeira, Róbson Ricardo, Bressan, Gustavo Costa
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Cell Death - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Humans Leukemia Leukemia - drug therapy Leukemia - metabolism Niacinamide - analogs & derivatives Niacinamide - chemical synthesis Niacinamide - chemistry Niacinamide - pharmacology Piperidines - chemical synthesis Piperidines - chemistry Piperidines - pharmacology Pre-mRNA splicing Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Serine/arginine-rich protein kinase SRPIN340 SRPK Trifluoromethyl arylamides Vincristine - pharmacology
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