Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping
BACKGROUND—Variability in premature ventricular contraction (PVC) coupling interval (CI) increases the risk of cardiomyopathy and sudden death. The autonomic nervous system regulates cardiac electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease pathogene...
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| Veröffentlicht in: | Circulation. Arrhythmia and electrophysiology 2017-04, Vol.10 (4), p.e004937-e004937 |
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| creator | Hamon, David Rajendran, Pradeep S Chui, Ray W Ajijola, Olujimi A Irie, Tadanobu Talebi, Ramin Salavatian, Siamak Vaseghi, Marmar Bradfield, Jason S Armour, J Andrew Ardell, Jeffrey L Shivkumar, Kalyanam |
| description | BACKGROUND—Variability in premature ventricular contraction (PVC) coupling interval (CI) increases the risk of cardiomyopathy and sudden death. The autonomic nervous system regulates cardiac electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease pathogenesis. The impact of PVCs on the intrinsic cardiac nervous system, a neural network on the heart, remains unknown. The objective was to determine the effect of PVCs and CI on intrinsic cardiac nervous system function in generating cardiac neuronal and electric instability using a novel cardioneural mapping approach.
METHODS AND RESULTS—In a porcine model (n=8), neuronal activity was recorded from a ventricular ganglion using a microelectrode array, and cardiac electrophysiological mapping was performed. Neurons were functionally classified based on their response to afferent and efferent cardiovascular stimuli, with neurons that responded to both defined as convergent (local reflex processors). Dynamic changes in neuronal activity were then evaluated in response to right ventricular outflow tract PVCs with fixed short, fixed long, and variable CI. PVC delivery elicited a greater neuronal response than all other stimuli (P |
| doi_str_mv | 10.1161/CIRCEP.116.004937 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1888682264</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1888682264</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2286-77a8ac57fa38c92ceda617b6e50c776c107a149b235a8b23939e3fb36c8690fa3</originalsourceid><addsrcrecordid>eNo9UctuFDEQHCEQCYEP4IJ85DLBj1nbww0NG7JSgIhHrlaP17tr8IwnfhAtP8UvxpvZcHC7pK4qt7uq6jXB54Rw8q5bfeuW1wd8jnHTMvGkOiVtQ2qGZfP0EZOmPalexPgLY04k4c-rEyobLPmCnlb_roMZIOVg0I0ZU7A6Owio8wWDTtaPBefJ2XGLVmMy4Q84dAPBQm-dTXv00cT0gP-aiDoIawsafTE5-LEwYVyjpTM6BT_t9tF657dWl8bDA969L6bRbncpoovgB_TdDtklGI3PRzc_Fq8i-AzTVIZ4WT3bgIvm1fE-q35eLH90l_XV10-r7sNVrSmVvBYCJOiF2ACTuqXarIET0XOzwFoIrgkWUPbSU7YAWWrLWsM2PeNa8hYX1Vn1dvadgr_N5Y9qsFEb5-bZFJFSckkpbwqVzFQdfIzBbNQU7ABhrwhWh5zUnNMBqzmnonlztM_9YNb_FY_BFEIzE-68K1uPv12-M0HtDLi0U5gwJopRTTERuMEY1-Vgzu4BfQ2jJA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1888682264</pqid></control><display><type>article</type><title>Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Hamon, David ; Rajendran, Pradeep S ; Chui, Ray W ; Ajijola, Olujimi A ; Irie, Tadanobu ; Talebi, Ramin ; Salavatian, Siamak ; Vaseghi, Marmar ; Bradfield, Jason S ; Armour, J Andrew ; Ardell, Jeffrey L ; Shivkumar, Kalyanam</creator><creatorcontrib>Hamon, David ; Rajendran, Pradeep S ; Chui, Ray W ; Ajijola, Olujimi A ; Irie, Tadanobu ; Talebi, Ramin ; Salavatian, Siamak ; Vaseghi, Marmar ; Bradfield, Jason S ; Armour, J Andrew ; Ardell, Jeffrey L ; Shivkumar, Kalyanam</creatorcontrib><description>BACKGROUND—Variability in premature ventricular contraction (PVC) coupling interval (CI) increases the risk of cardiomyopathy and sudden death. The autonomic nervous system regulates cardiac electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease pathogenesis. The impact of PVCs on the intrinsic cardiac nervous system, a neural network on the heart, remains unknown. The objective was to determine the effect of PVCs and CI on intrinsic cardiac nervous system function in generating cardiac neuronal and electric instability using a novel cardioneural mapping approach.
METHODS AND RESULTS—In a porcine model (n=8), neuronal activity was recorded from a ventricular ganglion using a microelectrode array, and cardiac electrophysiological mapping was performed. Neurons were functionally classified based on their response to afferent and efferent cardiovascular stimuli, with neurons that responded to both defined as convergent (local reflex processors). Dynamic changes in neuronal activity were then evaluated in response to right ventricular outflow tract PVCs with fixed short, fixed long, and variable CI. PVC delivery elicited a greater neuronal response than all other stimuli (P<0.001). Compared with fixed short and long CI, PVCs with variable CI had a greater impact on neuronal response (P<0.05 versus short CI), particularly on convergent neurons (P<0.05), as well as neurons receiving sympathetic (P<0.05) and parasympathetic input (P<0.05). The greatest cardiac electric instability was also observed after variable (short) CI PVCs.
CONCLUSIONS—Variable CI PVCs affect critical populations of intrinsic cardiac nervous system neurons and alter cardiac repolarization. These changes may be critical for arrhythmogenesis and remodeling, leading to cardiomyopathy.</description><identifier>ISSN: 1941-3149</identifier><identifier>EISSN: 1941-3084</identifier><identifier>DOI: 10.1161/CIRCEP.116.004937</identifier><identifier>PMID: 28408652</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Action Potentials ; Animals ; Autonomic Nervous System - physiopathology ; Cardiac Pacing, Artificial ; Cardiomyopathies - etiology ; Cardiomyopathies - physiopathology ; Disease Models, Animal ; Electrophysiologic Techniques, Cardiac ; Female ; Heart - innervation ; Heart Rate ; Male ; Myocardial Contraction ; Sus scrofa ; Time Factors ; Ventricular Function ; Ventricular Premature Complexes - complications ; Ventricular Premature Complexes - diagnosis ; Ventricular Premature Complexes - physiopathology</subject><ispartof>Circulation. Arrhythmia and electrophysiology, 2017-04, Vol.10 (4), p.e004937-e004937</ispartof><rights>2017 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2286-77a8ac57fa38c92ceda617b6e50c776c107a149b235a8b23939e3fb36c8690fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28408652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamon, David</creatorcontrib><creatorcontrib>Rajendran, Pradeep S</creatorcontrib><creatorcontrib>Chui, Ray W</creatorcontrib><creatorcontrib>Ajijola, Olujimi A</creatorcontrib><creatorcontrib>Irie, Tadanobu</creatorcontrib><creatorcontrib>Talebi, Ramin</creatorcontrib><creatorcontrib>Salavatian, Siamak</creatorcontrib><creatorcontrib>Vaseghi, Marmar</creatorcontrib><creatorcontrib>Bradfield, Jason S</creatorcontrib><creatorcontrib>Armour, J Andrew</creatorcontrib><creatorcontrib>Ardell, Jeffrey L</creatorcontrib><creatorcontrib>Shivkumar, Kalyanam</creatorcontrib><title>Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping</title><title>Circulation. Arrhythmia and electrophysiology</title><addtitle>Circ Arrhythm Electrophysiol</addtitle><description>BACKGROUND—Variability in premature ventricular contraction (PVC) coupling interval (CI) increases the risk of cardiomyopathy and sudden death. The autonomic nervous system regulates cardiac electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease pathogenesis. The impact of PVCs on the intrinsic cardiac nervous system, a neural network on the heart, remains unknown. The objective was to determine the effect of PVCs and CI on intrinsic cardiac nervous system function in generating cardiac neuronal and electric instability using a novel cardioneural mapping approach.
METHODS AND RESULTS—In a porcine model (n=8), neuronal activity was recorded from a ventricular ganglion using a microelectrode array, and cardiac electrophysiological mapping was performed. Neurons were functionally classified based on their response to afferent and efferent cardiovascular stimuli, with neurons that responded to both defined as convergent (local reflex processors). Dynamic changes in neuronal activity were then evaluated in response to right ventricular outflow tract PVCs with fixed short, fixed long, and variable CI. PVC delivery elicited a greater neuronal response than all other stimuli (P<0.001). Compared with fixed short and long CI, PVCs with variable CI had a greater impact on neuronal response (P<0.05 versus short CI), particularly on convergent neurons (P<0.05), as well as neurons receiving sympathetic (P<0.05) and parasympathetic input (P<0.05). The greatest cardiac electric instability was also observed after variable (short) CI PVCs.
CONCLUSIONS—Variable CI PVCs affect critical populations of intrinsic cardiac nervous system neurons and alter cardiac repolarization. These changes may be critical for arrhythmogenesis and remodeling, leading to cardiomyopathy.</description><subject>Action Potentials</subject><subject>Animals</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardiomyopathies - etiology</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Electrophysiologic Techniques, Cardiac</subject><subject>Female</subject><subject>Heart - innervation</subject><subject>Heart Rate</subject><subject>Male</subject><subject>Myocardial Contraction</subject><subject>Sus scrofa</subject><subject>Time Factors</subject><subject>Ventricular Function</subject><subject>Ventricular Premature Complexes - complications</subject><subject>Ventricular Premature Complexes - diagnosis</subject><subject>Ventricular Premature Complexes - physiopathology</subject><issn>1941-3149</issn><issn>1941-3084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UctuFDEQHCEQCYEP4IJ85DLBj1nbww0NG7JSgIhHrlaP17tr8IwnfhAtP8UvxpvZcHC7pK4qt7uq6jXB54Rw8q5bfeuW1wd8jnHTMvGkOiVtQ2qGZfP0EZOmPalexPgLY04k4c-rEyobLPmCnlb_roMZIOVg0I0ZU7A6Owio8wWDTtaPBefJ2XGLVmMy4Q84dAPBQm-dTXv00cT0gP-aiDoIawsafTE5-LEwYVyjpTM6BT_t9tF657dWl8bDA969L6bRbncpoovgB_TdDtklGI3PRzc_Fq8i-AzTVIZ4WT3bgIvm1fE-q35eLH90l_XV10-r7sNVrSmVvBYCJOiF2ACTuqXarIET0XOzwFoIrgkWUPbSU7YAWWrLWsM2PeNa8hYX1Vn1dvadgr_N5Y9qsFEb5-bZFJFSckkpbwqVzFQdfIzBbNQU7ABhrwhWh5zUnNMBqzmnonlztM_9YNb_FY_BFEIzE-68K1uPv12-M0HtDLi0U5gwJopRTTERuMEY1-Vgzu4BfQ2jJA</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Hamon, David</creator><creator>Rajendran, Pradeep S</creator><creator>Chui, Ray W</creator><creator>Ajijola, Olujimi A</creator><creator>Irie, Tadanobu</creator><creator>Talebi, Ramin</creator><creator>Salavatian, Siamak</creator><creator>Vaseghi, Marmar</creator><creator>Bradfield, Jason S</creator><creator>Armour, J Andrew</creator><creator>Ardell, Jeffrey L</creator><creator>Shivkumar, Kalyanam</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping</title><author>Hamon, David ; Rajendran, Pradeep S ; Chui, Ray W ; Ajijola, Olujimi A ; Irie, Tadanobu ; Talebi, Ramin ; Salavatian, Siamak ; Vaseghi, Marmar ; Bradfield, Jason S ; Armour, J Andrew ; Ardell, Jeffrey L ; Shivkumar, Kalyanam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2286-77a8ac57fa38c92ceda617b6e50c776c107a149b235a8b23939e3fb36c8690fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Action Potentials</topic><topic>Animals</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cardiomyopathies - etiology</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Electrophysiologic Techniques, Cardiac</topic><topic>Female</topic><topic>Heart - innervation</topic><topic>Heart Rate</topic><topic>Male</topic><topic>Myocardial Contraction</topic><topic>Sus scrofa</topic><topic>Time Factors</topic><topic>Ventricular Function</topic><topic>Ventricular Premature Complexes - complications</topic><topic>Ventricular Premature Complexes - diagnosis</topic><topic>Ventricular Premature Complexes - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamon, David</creatorcontrib><creatorcontrib>Rajendran, Pradeep S</creatorcontrib><creatorcontrib>Chui, Ray W</creatorcontrib><creatorcontrib>Ajijola, Olujimi A</creatorcontrib><creatorcontrib>Irie, Tadanobu</creatorcontrib><creatorcontrib>Talebi, Ramin</creatorcontrib><creatorcontrib>Salavatian, Siamak</creatorcontrib><creatorcontrib>Vaseghi, Marmar</creatorcontrib><creatorcontrib>Bradfield, Jason S</creatorcontrib><creatorcontrib>Armour, J Andrew</creatorcontrib><creatorcontrib>Ardell, Jeffrey L</creatorcontrib><creatorcontrib>Shivkumar, Kalyanam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation. Arrhythmia and electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamon, David</au><au>Rajendran, Pradeep S</au><au>Chui, Ray W</au><au>Ajijola, Olujimi A</au><au>Irie, Tadanobu</au><au>Talebi, Ramin</au><au>Salavatian, Siamak</au><au>Vaseghi, Marmar</au><au>Bradfield, Jason S</au><au>Armour, J Andrew</au><au>Ardell, Jeffrey L</au><au>Shivkumar, Kalyanam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping</atitle><jtitle>Circulation. Arrhythmia and electrophysiology</jtitle><addtitle>Circ Arrhythm Electrophysiol</addtitle><date>2017-04</date><risdate>2017</risdate><volume>10</volume><issue>4</issue><spage>e004937</spage><epage>e004937</epage><pages>e004937-e004937</pages><issn>1941-3149</issn><eissn>1941-3084</eissn><abstract>BACKGROUND—Variability in premature ventricular contraction (PVC) coupling interval (CI) increases the risk of cardiomyopathy and sudden death. The autonomic nervous system regulates cardiac electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease pathogenesis. The impact of PVCs on the intrinsic cardiac nervous system, a neural network on the heart, remains unknown. The objective was to determine the effect of PVCs and CI on intrinsic cardiac nervous system function in generating cardiac neuronal and electric instability using a novel cardioneural mapping approach.
METHODS AND RESULTS—In a porcine model (n=8), neuronal activity was recorded from a ventricular ganglion using a microelectrode array, and cardiac electrophysiological mapping was performed. Neurons were functionally classified based on their response to afferent and efferent cardiovascular stimuli, with neurons that responded to both defined as convergent (local reflex processors). Dynamic changes in neuronal activity were then evaluated in response to right ventricular outflow tract PVCs with fixed short, fixed long, and variable CI. PVC delivery elicited a greater neuronal response than all other stimuli (P<0.001). Compared with fixed short and long CI, PVCs with variable CI had a greater impact on neuronal response (P<0.05 versus short CI), particularly on convergent neurons (P<0.05), as well as neurons receiving sympathetic (P<0.05) and parasympathetic input (P<0.05). The greatest cardiac electric instability was also observed after variable (short) CI PVCs.
CONCLUSIONS—Variable CI PVCs affect critical populations of intrinsic cardiac nervous system neurons and alter cardiac repolarization. These changes may be critical for arrhythmogenesis and remodeling, leading to cardiomyopathy.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>28408652</pmid><doi>10.1161/CIRCEP.116.004937</doi></addata></record> |
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| ispartof | Circulation. Arrhythmia and electrophysiology, 2017-04, Vol.10 (4), p.e004937-e004937 |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Action Potentials Animals Autonomic Nervous System - physiopathology Cardiac Pacing, Artificial Cardiomyopathies - etiology Cardiomyopathies - physiopathology Disease Models, Animal Electrophysiologic Techniques, Cardiac Female Heart - innervation Heart Rate Male Myocardial Contraction Sus scrofa Time Factors Ventricular Function Ventricular Premature Complexes - complications Ventricular Premature Complexes - diagnosis Ventricular Premature Complexes - physiopathology |
| title | Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping |
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