Nonfamilial Hypertrophic Cardiomyopathy: Prevalence, Natural History, and Clinical Implications

BACKGROUND—Yield of causative variants in hypertrophic cardiomyopathy (HCM) is increased in some probands, suggesting different clinical subgroups of disease occur. We hypothesized that a negative family history and no sarcomere mutations represent a nonfamilial subgroup of HCM. We sought to determi...

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Veröffentlicht in:	Circulation. Cardiovascular genetics 2017-04, Vol.10 (2), p.e001620-e001620
Hauptverfasser:	Ingles, Jodie, Burns, Charlotte, Bagnall, Richard D, Lam, Lien, Yeates, Laura, Sarina, Tanya, Puranik, Rajesh, Briffa, Tom, Atherton, John J, Driscoll, Tim, Semsarian, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Aged Aged, 80 and over Area Under Curve Cardiac Myosins - genetics Cardiomyopathy, Hypertrophic - epidemiology Cardiomyopathy, Hypertrophic - genetics Cardiomyopathy, Hypertrophic - mortality Cardiomyopathy, Hypertrophic - pathology Carrier Proteins - genetics Cohort Studies Disease-Free Survival Female Genotype Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Male Middle Aged Myosin Heavy Chains - genetics Odds Ratio Pedigree Prevalence Retrospective Studies ROC Curve Sex Factors Troponin T - genetics Young Adult
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