Imaging evaluation of ablative margin and index tumor immediately after radiofrequency ablation for hepatocellular carcinoma: comparison between multidetector-row CT and MR imaging

Purpose To prospectively compare multidetector-row CT (MDCT) and MR imaging (MRI) in the assessment of the ablative margin (AM) and index tumor immediately after radiofrequency (RF) ablation for hepatocellular carcinoma (HCC) and assess whether non-contrast MRI with limited sequences (T1- and T2-wei...

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Veröffentlicht in:Abdominal imaging 2017-10, Vol.42 (10), p.2527-2537
Hauptverfasser: Kim, Sung Mo, Shin, Sang Soo, Lee, Byung Chan, Kim, Jin Woong, Heo, Suk Hee, Lim, Hyo Soon, Jeong, Yong Yeon
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container_end_page 2537
container_issue 10
container_start_page 2527
container_title Abdominal imaging
container_volume 42
creator Kim, Sung Mo
Shin, Sang Soo
Lee, Byung Chan
Kim, Jin Woong
Heo, Suk Hee
Lim, Hyo Soon
Jeong, Yong Yeon
description Purpose To prospectively compare multidetector-row CT (MDCT) and MR imaging (MRI) in the assessment of the ablative margin (AM) and index tumor immediately after radiofrequency (RF) ablation for hepatocellular carcinoma (HCC) and assess whether non-contrast MRI with limited sequences (T1- and T2-weighted imaging only) was superior to a conventional MDCT protocol. Methods A total of 33 consecutive patients with 42 HCCs were included in this study. Both MDCT and MR images were independently reviewed by two radiologists regarding the ability to visually discriminate between the AM and index tumor, and the AM status within ablation zones. The AM status was classified as AM-plus (AM completely surrounding the tumor), AM-zero (AM was partly discontinuous, without protrusion of the tumor), and AM-minus (AM was partly discontinuous, with protrusion of the tumor). During the follow-up period, the cumulative local tumor progression rates were analyzed using the Kaplan–Meier method and Cox proportional hazards model. To determine the added value of contrast-enhanced MR images, both reviewers separately evaluated the two sets (unenhanced and enhanced) of MR images. Results Visual discrimination between the AM and index tumor was possible in four (9.5%) and 34 (81%) of the 42 ablation zones using MDCT and MRI, respectively ( p  
doi_str_mv 10.1007/s00261-017-1146-z
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Methods A total of 33 consecutive patients with 42 HCCs were included in this study. Both MDCT and MR images were independently reviewed by two radiologists regarding the ability to visually discriminate between the AM and index tumor, and the AM status within ablation zones. The AM status was classified as AM-plus (AM completely surrounding the tumor), AM-zero (AM was partly discontinuous, without protrusion of the tumor), and AM-minus (AM was partly discontinuous, with protrusion of the tumor). During the follow-up period, the cumulative local tumor progression rates were analyzed using the Kaplan–Meier method and Cox proportional hazards model. To determine the added value of contrast-enhanced MR images, both reviewers separately evaluated the two sets (unenhanced and enhanced) of MR images. Results Visual discrimination between the AM and index tumor was possible in four (9.5%) and 34 (81%) of the 42 ablation zones using MDCT and MRI, respectively ( p  &lt; 0.001). Thirty-eight and four cases were classified as AM-plus and AM-zero on MDCT images, respectively, whereas the ablation zones were categorized as AM-plus ( n  = 32), AM-zero ( n  = 9), and AM-minus ( n  = 1) when examining the MR images. The cumulative incidence of local tumor progression was significantly lower in cases with AM-plus on MRI ( p  = 0.007). Contrast-enhanced MRI had no added value for the assessment of the AM and index tumor. Conclusion MRI was superior to MDCT for the differential assessment of the AM and index tumor immediately after RF ablation for HCC. Non-contrast MRI was also superior to the conventional MDCT protocol.</description><identifier>ISSN: 2366-004X</identifier><identifier>EISSN: 2366-0058</identifier><identifier>DOI: 10.1007/s00261-017-1146-z</identifier><identifier>PMID: 28409202</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Ablation ; Adult ; Aged ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Catheter Ablation - methods ; Computed tomography ; Contrast Media ; Disease Progression ; Female ; Gastroenterology ; Hazards ; Hepatocellular carcinoma ; Hepatology ; Humans ; Image contrast ; Image enhancement ; Imaging ; Liver cancer ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Margins of Excision ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Prospective Studies ; Radio frequency ; Radio Waves ; Radiofrequency ablation ; Radiology ; Tomography, X-Ray Computed - methods ; Treatment Outcome ; Visual discrimination</subject><ispartof>Abdominal imaging, 2017-10, Vol.42 (10), p.2527-2537</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>Abdominal Radiology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p212t-bf79ac52c76d17f81b2b724faeaf44c31b2935ea0de96826cfb6ec1c41bf03b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00261-017-1146-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00261-017-1146-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28409202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Sung Mo</creatorcontrib><creatorcontrib>Shin, Sang Soo</creatorcontrib><creatorcontrib>Lee, Byung Chan</creatorcontrib><creatorcontrib>Kim, Jin Woong</creatorcontrib><creatorcontrib>Heo, Suk Hee</creatorcontrib><creatorcontrib>Lim, Hyo Soon</creatorcontrib><creatorcontrib>Jeong, Yong Yeon</creatorcontrib><title>Imaging evaluation of ablative margin and index tumor immediately after radiofrequency ablation for hepatocellular carcinoma: comparison between multidetector-row CT and MR imaging</title><title>Abdominal imaging</title><addtitle>Abdom Radiol</addtitle><addtitle>Abdom Radiol (NY)</addtitle><description>Purpose To prospectively compare multidetector-row CT (MDCT) and MR imaging (MRI) in the assessment of the ablative margin (AM) and index tumor immediately after radiofrequency (RF) ablation for hepatocellular carcinoma (HCC) and assess whether non-contrast MRI with limited sequences (T1- and T2-weighted imaging only) was superior to a conventional MDCT protocol. Methods A total of 33 consecutive patients with 42 HCCs were included in this study. Both MDCT and MR images were independently reviewed by two radiologists regarding the ability to visually discriminate between the AM and index tumor, and the AM status within ablation zones. The AM status was classified as AM-plus (AM completely surrounding the tumor), AM-zero (AM was partly discontinuous, without protrusion of the tumor), and AM-minus (AM was partly discontinuous, with protrusion of the tumor). During the follow-up period, the cumulative local tumor progression rates were analyzed using the Kaplan–Meier method and Cox proportional hazards model. To determine the added value of contrast-enhanced MR images, both reviewers separately evaluated the two sets (unenhanced and enhanced) of MR images. Results Visual discrimination between the AM and index tumor was possible in four (9.5%) and 34 (81%) of the 42 ablation zones using MDCT and MRI, respectively ( p  &lt; 0.001). Thirty-eight and four cases were classified as AM-plus and AM-zero on MDCT images, respectively, whereas the ablation zones were categorized as AM-plus ( n  = 32), AM-zero ( n  = 9), and AM-minus ( n  = 1) when examining the MR images. The cumulative incidence of local tumor progression was significantly lower in cases with AM-plus on MRI ( p  = 0.007). Contrast-enhanced MRI had no added value for the assessment of the AM and index tumor. Conclusion MRI was superior to MDCT for the differential assessment of the AM and index tumor immediately after RF ablation for HCC. 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Public Health</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Radio frequency</subject><subject>Radio Waves</subject><subject>Radiofrequency ablation</subject><subject>Radiology</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Treatment Outcome</subject><subject>Visual discrimination</subject><issn>2366-004X</issn><issn>2366-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkcFu1DAQhiMEolXpA3BBlrhwCdhO4iTc0KpApSIkVCRu1tgZL65iO9hOy_a5eEC83QUhTh5rPv0z__xV9ZzR14zS_k2ilAtWU9bXjLWivn9UnfJGiJrSbnj8t26_nVTnKd1QSpnoGOPd0-qEDy0dOeWn1a9LB1vrtwRvYV4h2-BJMATUXOpbJA5iaRPwE7F-wp8kry5EYp3DyULGeUfAZIwkwmSDifhjRa93R4EiZgr9HRfIQeM8rzNEoiFq64ODt0QHt0C0qYAK8x2iJ26ds50wo84h1jHckc31w_xPX8rYh2WfVU8MzAnPj-9Z9fX9xfXmY331-cPl5t1VvXDGc61MP4LuuO7FxHozMMVVz1sDCKZtdVP-Y9Mh0AlHMXChjRKomW6ZMrRRfXNWvTroLjEUXylLZ9PeBngMa5JsGAbRD0WkoC__Q2_CGn3ZTrKxZSPnZUShXhypVZUDyiUWR3En_-RRAH4AUmn5LcZ_ZKjc5y4PucuSu9znLu-b32-7otg</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Kim, Sung Mo</creator><creator>Shin, Sang Soo</creator><creator>Lee, Byung Chan</creator><creator>Kim, Jin Woong</creator><creator>Heo, Suk Hee</creator><creator>Lim, Hyo Soon</creator><creator>Jeong, Yong Yeon</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20171001</creationdate><title>Imaging evaluation of ablative margin and index tumor immediately after radiofrequency ablation for hepatocellular carcinoma: comparison between multidetector-row CT and MR imaging</title><author>Kim, Sung Mo ; 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Methods A total of 33 consecutive patients with 42 HCCs were included in this study. Both MDCT and MR images were independently reviewed by two radiologists regarding the ability to visually discriminate between the AM and index tumor, and the AM status within ablation zones. The AM status was classified as AM-plus (AM completely surrounding the tumor), AM-zero (AM was partly discontinuous, without protrusion of the tumor), and AM-minus (AM was partly discontinuous, with protrusion of the tumor). During the follow-up period, the cumulative local tumor progression rates were analyzed using the Kaplan–Meier method and Cox proportional hazards model. To determine the added value of contrast-enhanced MR images, both reviewers separately evaluated the two sets (unenhanced and enhanced) of MR images. Results Visual discrimination between the AM and index tumor was possible in four (9.5%) and 34 (81%) of the 42 ablation zones using MDCT and MRI, respectively ( p  &lt; 0.001). Thirty-eight and four cases were classified as AM-plus and AM-zero on MDCT images, respectively, whereas the ablation zones were categorized as AM-plus ( n  = 32), AM-zero ( n  = 9), and AM-minus ( n  = 1) when examining the MR images. The cumulative incidence of local tumor progression was significantly lower in cases with AM-plus on MRI ( p  = 0.007). Contrast-enhanced MRI had no added value for the assessment of the AM and index tumor. Conclusion MRI was superior to MDCT for the differential assessment of the AM and index tumor immediately after RF ablation for HCC. Non-contrast MRI was also superior to the conventional MDCT protocol.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28409202</pmid><doi>10.1007/s00261-017-1146-z</doi><tpages>11</tpages></addata></record>
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subjects Ablation
Adult
Aged
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Catheter Ablation - methods
Computed tomography
Contrast Media
Disease Progression
Female
Gastroenterology
Hazards
Hepatocellular carcinoma
Hepatology
Humans
Image contrast
Image enhancement
Imaging
Liver cancer
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Margins of Excision
Medicine
Medicine & Public Health
Middle Aged
Prospective Studies
Radio frequency
Radio Waves
Radiofrequency ablation
Radiology
Tomography, X-Ray Computed - methods
Treatment Outcome
Visual discrimination
title Imaging evaluation of ablative margin and index tumor immediately after radiofrequency ablation for hepatocellular carcinoma: comparison between multidetector-row CT and MR imaging
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