Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice
In most mammalian species, arsenic biotransformation occurs primarily by biomethylation with dimethylarsinic acid being the predominant metabolite excreted in the urine. Folbp1 (folate binding protein-1) mediated intracellular folate uptake is one route by which cells harvest folate cofactors. In li...
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| Veröffentlicht in: | Toxicology letters 2003-11, Vol.145 (2), p.167-174 |
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| creator | Spiegelstein, Ofer Lu, Xiufen Le, X.Chris Troen, Aron Selhub, Jacob Melnyk, Stepan James, S.Jill Finnell, Richard H. |
| description | In most mammalian species, arsenic biotransformation occurs primarily by biomethylation with dimethylarsinic acid being the predominant metabolite excreted in the urine. Folbp1 (folate binding protein-1) mediated intracellular folate uptake is one route by which cells harvest folate cofactors. In light of the likely relationship between folate biochemistry and arsenic biotransformation, our experiments were designed to test: (1) whether Folbp1 is an important determinant in arsenic biotransformation, by performing urinary arsenic speciation in Folbp1 nullizygous (Folbp1
−/−) and wildtype control mice, and (2) whether dietary folate deficiency alters arsenic biotransformation in these mice. Compared to normal folate intake, folate deficiency caused lower amounts of arsenic to be excreted in the urine of both the wildtype controls and Folbp1
−/− mice. Folbp1
−/− mice excreted more dimethylarsinic acid than wildtype control mice during folate deficiency, but not during normal folate intake. The present data suggest that inadequate folate intake may result in decreased biotransformation and excretion of arsenic, which is likely to increase arsenic exposure and related toxicities. |
| doi_str_mv | 10.1016/S0378-4274(03)00307-2 |
| format | Article |
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−/−) and wildtype control mice, and (2) whether dietary folate deficiency alters arsenic biotransformation in these mice. Compared to normal folate intake, folate deficiency caused lower amounts of arsenic to be excreted in the urine of both the wildtype controls and Folbp1
−/− mice. Folbp1
−/− mice excreted more dimethylarsinic acid than wildtype control mice during folate deficiency, but not during normal folate intake. The present data suggest that inadequate folate intake may result in decreased biotransformation and excretion of arsenic, which is likely to increase arsenic exposure and related toxicities.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/S0378-4274(03)00307-2</identifier><identifier>PMID: 14581169</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Arsenates - urine ; Arsenic ; Arsenic - metabolism ; Arsenic - toxicity ; Arsenic - urine ; Arsenic Poisoning - urine ; Arsenicals - urine ; Arsenites - urine ; Biological and medical sciences ; Biotransformation ; Cacodylic Acid - urine ; Carrier Proteins - metabolism ; Chemical and industrial products toxicology. Toxic occupational diseases ; Cross-Over Studies ; Detoxification ; Excretion ; Folate deficiency ; Folate Receptors, GPI-Anchored ; Folic acid ; Folic Acid - blood ; Folic Acid - metabolism ; Folic Acid Deficiency - metabolism ; Folic Acid Deficiency - urine ; Male ; Medical sciences ; Metals and various inorganic compounds ; Mice ; Mice, Knockout ; Receptors, Cell Surface ; S-Adenosylhomocysteine - blood ; S-Adenosylmethionine - blood ; Toxicology</subject><ispartof>Toxicology letters, 2003-11, Vol.145 (2), p.167-174</ispartof><rights>2003 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-31c4c626a3da460a960fd067705371f1077850c5a9ad0e170c69c4d10e9581b43</citedby><cites>FETCH-LOGICAL-c474t-31c4c626a3da460a960fd067705371f1077850c5a9ad0e170c69c4d10e9581b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-4274(03)00307-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16408691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14581169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spiegelstein, Ofer</creatorcontrib><creatorcontrib>Lu, Xiufen</creatorcontrib><creatorcontrib>Le, X.Chris</creatorcontrib><creatorcontrib>Troen, Aron</creatorcontrib><creatorcontrib>Selhub, Jacob</creatorcontrib><creatorcontrib>Melnyk, Stepan</creatorcontrib><creatorcontrib>James, S.Jill</creatorcontrib><creatorcontrib>Finnell, Richard H.</creatorcontrib><title>Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>In most mammalian species, arsenic biotransformation occurs primarily by biomethylation with dimethylarsinic acid being the predominant metabolite excreted in the urine. Folbp1 (folate binding protein-1) mediated intracellular folate uptake is one route by which cells harvest folate cofactors. In light of the likely relationship between folate biochemistry and arsenic biotransformation, our experiments were designed to test: (1) whether Folbp1 is an important determinant in arsenic biotransformation, by performing urinary arsenic speciation in Folbp1 nullizygous (Folbp1
−/−) and wildtype control mice, and (2) whether dietary folate deficiency alters arsenic biotransformation in these mice. Compared to normal folate intake, folate deficiency caused lower amounts of arsenic to be excreted in the urine of both the wildtype controls and Folbp1
−/− mice. Folbp1
−/− mice excreted more dimethylarsinic acid than wildtype control mice during folate deficiency, but not during normal folate intake. The present data suggest that inadequate folate intake may result in decreased biotransformation and excretion of arsenic, which is likely to increase arsenic exposure and related toxicities.</description><subject>Animals</subject><subject>Arsenates - urine</subject><subject>Arsenic</subject><subject>Arsenic - metabolism</subject><subject>Arsenic - toxicity</subject><subject>Arsenic - urine</subject><subject>Arsenic Poisoning - urine</subject><subject>Arsenicals - urine</subject><subject>Arsenites - urine</subject><subject>Biological and medical sciences</subject><subject>Biotransformation</subject><subject>Cacodylic Acid - urine</subject><subject>Carrier Proteins - metabolism</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Cross-Over Studies</subject><subject>Detoxification</subject><subject>Excretion</subject><subject>Folate deficiency</subject><subject>Folate Receptors, GPI-Anchored</subject><subject>Folic acid</subject><subject>Folic Acid - blood</subject><subject>Folic Acid - metabolism</subject><subject>Folic Acid Deficiency - metabolism</subject><subject>Folic Acid Deficiency - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Receptors, Cell Surface</subject><subject>S-Adenosylhomocysteine - blood</subject><subject>S-Adenosylmethionine - blood</subject><subject>Toxicology</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFP3DAQhS3Uqiy0P4HKlyI4BMZrx05OCCFokZB6gJ4trz2uXBJ7ayet-u_rZRc4crI0-t7zvDeEHDE4Y8Dk-T1w1TViqcQJ8FMADqpZ7pEF61TfcCb7d2TxguyTg1J-AYAUsv1A9ploO1aZBfl77T3aqdDkqQs4mfyP-jSYCWmIk3lEaqJ7nqxCdCH-pOucJgyxYfTkJg2rNTulKdI5h7iRlzXaYKZQR9W0JBfmkZpcMG5d6RgsfiTvvRkKftq9h-THzfXD1bfm7vvX26vLu8YKJaYaxAorl9JwZ4QE00vwDqRS0HLFPAOluhZsa3rjAJkCK3srHAPsa8KV4IfkeOtbd_49Y5n0GIrFYTAR01w067qOtwoq2G5Bm1MpGb1e5zDWPJqB3jSunxrXmzo1cP3UuF5W3efdB_NqRPeq2lVcgS87wBRrBp9NtKG8clJAJ3tWuYsth7WOPwGzLjZgtOhCrhfSLoU3VvkPwqaciA</recordid><startdate>20031130</startdate><enddate>20031130</enddate><creator>Spiegelstein, Ofer</creator><creator>Lu, Xiufen</creator><creator>Le, X.Chris</creator><creator>Troen, Aron</creator><creator>Selhub, Jacob</creator><creator>Melnyk, Stepan</creator><creator>James, S.Jill</creator><creator>Finnell, Richard H.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20031130</creationdate><title>Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice</title><author>Spiegelstein, Ofer ; Lu, Xiufen ; Le, X.Chris ; Troen, Aron ; Selhub, Jacob ; Melnyk, Stepan ; James, S.Jill ; Finnell, Richard H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-31c4c626a3da460a960fd067705371f1077850c5a9ad0e170c69c4d10e9581b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Arsenates - urine</topic><topic>Arsenic</topic><topic>Arsenic - metabolism</topic><topic>Arsenic - toxicity</topic><topic>Arsenic - urine</topic><topic>Arsenic Poisoning - urine</topic><topic>Arsenicals - urine</topic><topic>Arsenites - urine</topic><topic>Biological and medical sciences</topic><topic>Biotransformation</topic><topic>Cacodylic Acid - urine</topic><topic>Carrier Proteins - metabolism</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Cross-Over Studies</topic><topic>Detoxification</topic><topic>Excretion</topic><topic>Folate deficiency</topic><topic>Folate Receptors, GPI-Anchored</topic><topic>Folic acid</topic><topic>Folic Acid - blood</topic><topic>Folic Acid - metabolism</topic><topic>Folic Acid Deficiency - metabolism</topic><topic>Folic Acid Deficiency - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Receptors, Cell Surface</topic><topic>S-Adenosylhomocysteine - blood</topic><topic>S-Adenosylmethionine - blood</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spiegelstein, Ofer</creatorcontrib><creatorcontrib>Lu, Xiufen</creatorcontrib><creatorcontrib>Le, X.Chris</creatorcontrib><creatorcontrib>Troen, Aron</creatorcontrib><creatorcontrib>Selhub, Jacob</creatorcontrib><creatorcontrib>Melnyk, Stepan</creatorcontrib><creatorcontrib>James, S.Jill</creatorcontrib><creatorcontrib>Finnell, Richard H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spiegelstein, Ofer</au><au>Lu, Xiufen</au><au>Le, X.Chris</au><au>Troen, Aron</au><au>Selhub, Jacob</au><au>Melnyk, Stepan</au><au>James, S.Jill</au><au>Finnell, Richard H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2003-11-30</date><risdate>2003</risdate><volume>145</volume><issue>2</issue><spage>167</spage><epage>174</epage><pages>167-174</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>In most mammalian species, arsenic biotransformation occurs primarily by biomethylation with dimethylarsinic acid being the predominant metabolite excreted in the urine. Folbp1 (folate binding protein-1) mediated intracellular folate uptake is one route by which cells harvest folate cofactors. In light of the likely relationship between folate biochemistry and arsenic biotransformation, our experiments were designed to test: (1) whether Folbp1 is an important determinant in arsenic biotransformation, by performing urinary arsenic speciation in Folbp1 nullizygous (Folbp1
−/−) and wildtype control mice, and (2) whether dietary folate deficiency alters arsenic biotransformation in these mice. Compared to normal folate intake, folate deficiency caused lower amounts of arsenic to be excreted in the urine of both the wildtype controls and Folbp1
−/− mice. Folbp1
−/− mice excreted more dimethylarsinic acid than wildtype control mice during folate deficiency, but not during normal folate intake. The present data suggest that inadequate folate intake may result in decreased biotransformation and excretion of arsenic, which is likely to increase arsenic exposure and related toxicities.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>14581169</pmid><doi>10.1016/S0378-4274(03)00307-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 2003-11, Vol.145 (2), p.167-174 |
| issn | 0378-4274 1879-3169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18883570 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Arsenates - urine Arsenic Arsenic - metabolism Arsenic - toxicity Arsenic - urine Arsenic Poisoning - urine Arsenicals - urine Arsenites - urine Biological and medical sciences Biotransformation Cacodylic Acid - urine Carrier Proteins - metabolism Chemical and industrial products toxicology. Toxic occupational diseases Cross-Over Studies Detoxification Excretion Folate deficiency Folate Receptors, GPI-Anchored Folic acid Folic Acid - blood Folic Acid - metabolism Folic Acid Deficiency - metabolism Folic Acid Deficiency - urine Male Medical sciences Metals and various inorganic compounds Mice Mice, Knockout Receptors, Cell Surface S-Adenosylhomocysteine - blood S-Adenosylmethionine - blood Toxicology |
| title | Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice |
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