Role of poly(ADP-ribose)polymerase in cisplatin-induced injury in LLC-PK1 cells

Acute renal failure is a dose-limiting factor during cisplatin chemotherapy. We have previously shown in rats that the hydroxyl radical scavenger edaravone reverses cisplatin-induced in vivo renal damage. In the present study, the role of poly(ADP-ribose) polymerase (PARP) in cisplatin nephrotoxicit...

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Veröffentlicht in:	Free radical biology & medicine 2003-10, Vol.35 (8), p.966-977
Hauptverfasser:	Shino, Yuki, Itoh, Yoshinori, Kubota, Toshio, Yano, Takahisa, Sendo, Toshiaki, Oishi, Ryozo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Annexin A5 - metabolism Antineoplastic Agents - toxicity Apoptosis - drug effects ATP Cisplatin Cisplatin - toxicity Enzyme Inhibitors - pharmacology Free Radical Scavengers - pharmacology Free radicals Hydroxyl radical Hydroxyl Radical - metabolism In Situ Nick-End Labeling Kidney Tubules - enzymology Kidney Tubules - pathology LLC-PK1 LLC-PK1 Cells Necrosis Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - immunology Poly(ADP-ribose) Polymerases - metabolism Swine
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