Environmental biodosimetry: a biologically relevant tool for ecological risk assessment and biomonitoring
Biodosimetry, the estimation of received doses by determining the frequency of radiation-induced chromosome aberrations, is widely applied in humans acutely exposed as a result of accidents or for clinical purposes, but biodosimetric techniques have not been utilized in organisms chronically exposed...
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| Veröffentlicht in: | Journal of environmental radioactivity 2003, Vol.66 (1), p.121-139 |
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| container_title | Journal of environmental radioactivity |
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| creator | Ulsh, B Hinton, T.G Congdon, J.D Dugan, L.C Whicker, F.W Bedford, J.S |
| description | Biodosimetry, the estimation of received doses by determining the frequency of radiation-induced chromosome aberrations, is widely applied in humans acutely exposed as a result of accidents or for clinical purposes, but biodosimetric techniques have not been utilized in organisms chronically exposed to radionuclides in contaminated environments. The application of biodosimetry to environmental exposure scenarios could greatly improve the accuracy, and reduce the uncertainties, of ecological risk assessments and biomonitoring studies, because no assumptions are required regarding external exposure rates and the movement of organisms into and out of contaminated areas. Furthermore, unlike residue analyses of environmental media, environmental biodosimetry provides a genetically relevant biomarker of cumulative lifetime exposure. Symmetrical chromosome translocations can impact reproductive success, and could therefore prove to be ecologically relevant as well. We describe our experience in studying aberrations in the yellow-bellied slider turtle as an example of environmental biodosimetry. |
| doi_str_mv | 10.1016/S0265-931X(02)00119-4 |
| format | Article |
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The application of biodosimetry to environmental exposure scenarios could greatly improve the accuracy, and reduce the uncertainties, of ecological risk assessments and biomonitoring studies, because no assumptions are required regarding external exposure rates and the movement of organisms into and out of contaminated areas. Furthermore, unlike residue analyses of environmental media, environmental biodosimetry provides a genetically relevant biomarker of cumulative lifetime exposure. Symmetrical chromosome translocations can impact reproductive success, and could therefore prove to be ecologically relevant as well. 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The application of biodosimetry to environmental exposure scenarios could greatly improve the accuracy, and reduce the uncertainties, of ecological risk assessments and biomonitoring studies, because no assumptions are required regarding external exposure rates and the movement of organisms into and out of contaminated areas. Furthermore, unlike residue analyses of environmental media, environmental biodosimetry provides a genetically relevant biomarker of cumulative lifetime exposure. Symmetrical chromosome translocations can impact reproductive success, and could therefore prove to be ecologically relevant as well. We describe our experience in studying aberrations in the yellow-bellied slider turtle as an example of environmental biodosimetry.</description><subject>Animals</subject><subject>Chromosome aberrations</subject><subject>Cytogenetic Analysis - methods</subject><subject>Cytogenetic Analysis - standards</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Ecosystem</subject><subject>Environmental biodosimetry</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Exposure - analysis</subject><subject>Fluorescent in-situ hybridization</subject><subject>Freshwater</subject><subject>Incidence</subject><subject>Lymphocytes</subject><subject>Pseudemys scripta</subject><subject>Radiation Monitoring - methods</subject><subject>Radiation Monitoring - standards</subject><subject>Reproduction - radiation effects</subject><subject>Risk Assessment - methods</subject><subject>Risk Assessment - standards</subject><subject>Sensitivity and Specificity</subject><subject>Trachemys scripta</subject><subject>Translocation, Genetic - genetics</subject><subject>Translocation, Genetic - radiation effects</subject><subject>Turtles - blood</subject><subject>Turtles - genetics</subject><subject>Turtles - physiology</subject><subject>Yellow-bellied slider turtle</subject><issn>0265-931X</issn><issn>1879-1700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFCEUx4nR2G31I2g4GT2M8pgZBrw0pmnVpIkHNfFGGHg0KAMVZjfZb-9Md9XjHggh_P7vPfgR8gLYW2Ag3n1lXPSNauHHa8bfMAagmu4R2YAcVAMDY4_J5h9yRs5r_blAA5P8KTkD3ivGhnZDwnXahZLThGk2kY4hu1zDhHPZv6dmPcd8F6yJcU8LRtyZNNM550h9LhTt32taQv1FTa1Y61qLmuTW9JRTmHMJ6e4ZeeJNrPj8uF-Q7zfX364-NbdfPn6--nDb2I63c6MMh2VJ6a0FKXolRslax73iniuQnRNu4AOa5aHGGQAzMtYra72E0XPfXpBXh7r3Jf_eYp31FKrFGE3CvK0apBwG1vanQQE9F1KcBjvRL6PCAvYH0JZca0Gv70uYTNlrYHq1ph-s6VWJZlw_WNPdknt5bLAdJ3T_U0dNC3B5AHD5uF3AoqsNmCy6UNDO2uVwosUf6QKpJg</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Ulsh, B</creator><creator>Hinton, T.G</creator><creator>Congdon, J.D</creator><creator>Dugan, L.C</creator><creator>Whicker, F.W</creator><creator>Bedford, J.S</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TV</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>2003</creationdate><title>Environmental biodosimetry: a biologically relevant tool for ecological risk assessment and biomonitoring</title><author>Ulsh, B ; Hinton, T.G ; Congdon, J.D ; Dugan, L.C ; Whicker, F.W ; Bedford, J.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-9a219a288fcc186596b803d2f92f29184d6d727ea187ada11ab0059ccf81bf2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Chromosome aberrations</topic><topic>Cytogenetic Analysis - methods</topic><topic>Cytogenetic Analysis - standards</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Ecosystem</topic><topic>Environmental biodosimetry</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Exposure - analysis</topic><topic>Fluorescent in-situ hybridization</topic><topic>Freshwater</topic><topic>Incidence</topic><topic>Lymphocytes</topic><topic>Pseudemys scripta</topic><topic>Radiation Monitoring - methods</topic><topic>Radiation Monitoring - standards</topic><topic>Reproduction - radiation effects</topic><topic>Risk Assessment - methods</topic><topic>Risk Assessment - standards</topic><topic>Sensitivity and Specificity</topic><topic>Trachemys scripta</topic><topic>Translocation, Genetic - genetics</topic><topic>Translocation, Genetic - radiation effects</topic><topic>Turtles - blood</topic><topic>Turtles - genetics</topic><topic>Turtles - physiology</topic><topic>Yellow-bellied slider turtle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ulsh, B</creatorcontrib><creatorcontrib>Hinton, T.G</creatorcontrib><creatorcontrib>Congdon, J.D</creatorcontrib><creatorcontrib>Dugan, L.C</creatorcontrib><creatorcontrib>Whicker, F.W</creatorcontrib><creatorcontrib>Bedford, J.S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Journal of environmental radioactivity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ulsh, B</au><au>Hinton, T.G</au><au>Congdon, J.D</au><au>Dugan, L.C</au><au>Whicker, F.W</au><au>Bedford, J.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental biodosimetry: a biologically relevant tool for ecological risk assessment and biomonitoring</atitle><jtitle>Journal of environmental radioactivity</jtitle><addtitle>J Environ Radioact</addtitle><date>2003</date><risdate>2003</risdate><volume>66</volume><issue>1</issue><spage>121</spage><epage>139</epage><pages>121-139</pages><issn>0265-931X</issn><eissn>1879-1700</eissn><abstract>Biodosimetry, the estimation of received doses by determining the frequency of radiation-induced chromosome aberrations, is widely applied in humans acutely exposed as a result of accidents or for clinical purposes, but biodosimetric techniques have not been utilized in organisms chronically exposed to radionuclides in contaminated environments. The application of biodosimetry to environmental exposure scenarios could greatly improve the accuracy, and reduce the uncertainties, of ecological risk assessments and biomonitoring studies, because no assumptions are required regarding external exposure rates and the movement of organisms into and out of contaminated areas. Furthermore, unlike residue analyses of environmental media, environmental biodosimetry provides a genetically relevant biomarker of cumulative lifetime exposure. Symmetrical chromosome translocations can impact reproductive success, and could therefore prove to be ecologically relevant as well. We describe our experience in studying aberrations in the yellow-bellied slider turtle as an example of environmental biodosimetry.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>12590073</pmid><doi>10.1016/S0265-931X(02)00119-4</doi><tpages>19</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0265-931X |
| ispartof | Journal of environmental radioactivity, 2003, Vol.66 (1), p.121-139 |
| issn | 0265-931X 1879-1700 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Chromosome aberrations Cytogenetic Analysis - methods Cytogenetic Analysis - standards Dose-Response Relationship, Radiation Ecosystem Environmental biodosimetry Environmental Exposure - adverse effects Environmental Exposure - analysis Fluorescent in-situ hybridization Freshwater Incidence Lymphocytes Pseudemys scripta Radiation Monitoring - methods Radiation Monitoring - standards Reproduction - radiation effects Risk Assessment - methods Risk Assessment - standards Sensitivity and Specificity Trachemys scripta Translocation, Genetic - genetics Translocation, Genetic - radiation effects Turtles - blood Turtles - genetics Turtles - physiology Yellow-bellied slider turtle |
| title | Environmental biodosimetry: a biologically relevant tool for ecological risk assessment and biomonitoring |
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