Central Insulin Administration Maintains Reproductive Behavior in Diabetic Female Rats

Diabetic female rats have decreased ovulation, reproductive behavior and luteinizing hormone surges. Peripheral insulin treatment restores the phenotype to normal and also corrects many of the metabolic changes. To further evaluate the role of insulin in the specific maintenance of reproductive beha...

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Veröffentlicht in:	Neuroendocrinology 2003-08, Vol.78 (2), p.90-95
Hauptverfasser:	Kovacs, Peter, Morales, Jose C., Karkanias, George B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Behavior, Animal Biological and medical sciences Blood Glucose - drug effects Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - physiopathology Diabetes. Impaired glucose tolerance Disease Models, Animal Drug Interactions Endocrine pancreas. Apud cells (diseases) Endocrinopathies Estradiol - analogs & derivatives Estradiol - pharmacology Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gonadal Steroid Hormones - pharmacology Gonadal Steroids and Regulation of Reproductive Hormones Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - therapeutic use Injections, Intraventricular - methods Insulin - administration & dosage Insulin - therapeutic use Male Medical sciences Motor Activity - drug effects Ovariectomy - methods Progesterone - pharmacology Rats Rats, Sprague-Dawley Sexual Behavior - drug effects
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